DK576184D0 - Substituerede trans-1,2-diaminocyclohexylamidforbindelser - Google Patents
Substituerede trans-1,2-diaminocyclohexylamidforbindelserInfo
- Publication number
- DK576184D0 DK576184D0 DK576184A DK576184A DK576184D0 DK 576184 D0 DK576184 D0 DK 576184D0 DK 576184 A DK576184 A DK 576184A DK 576184 A DK576184 A DK 576184A DK 576184 D0 DK576184 D0 DK 576184D0
- Authority
- DK
- Denmark
- Prior art keywords
- diaminocyclohexylamide
- compounds
- substituted trans
- trans
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55873183A | 1983-12-06 | 1983-12-06 | |
| US06/669,922 US4656182A (en) | 1983-12-06 | 1984-11-13 | Substituted trans-1,2-diaminocyclohexyl amide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK576184D0 true DK576184D0 (da) | 1984-12-04 |
| DK576184A DK576184A (da) | 1985-06-07 |
Family
ID=27071828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK576184A DK576184A (da) | 1983-12-06 | 1984-12-04 | Substituerede trans-1,2-diaminocyclohexylamidforbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4656182A (da) |
| EP (1) | EP0147085B1 (da) |
| KR (1) | KR880002532B1 (da) |
| AU (1) | AU565236B2 (da) |
| CA (1) | CA1234808A (da) |
| DE (1) | DE3481614D1 (da) |
| DK (1) | DK576184A (da) |
| ES (1) | ES538243A0 (da) |
| FI (1) | FI80031C (da) |
| GR (1) | GR81174B (da) |
| HU (1) | HU200162B (da) |
| IE (1) | IE57673B1 (da) |
| IL (1) | IL73632A (da) |
| NO (1) | NO165838C (da) |
| NZ (1) | NZ210440A (da) |
| OA (1) | OA07885A (da) |
| PH (1) | PH21740A (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010085A (en) * | 1986-09-10 | 1991-04-23 | E. I. Du Pont De Nemours And Company | Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine derivatives |
| US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| MY101368A (en) * | 1986-09-10 | 1991-09-05 | Bristol Myers Squibb Pharma Company | Benzo-fused cyclaolkane and oxa-and thai,cycloalkane trans-1, 2-daimine derivatives |
| FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| GB8803259D0 (en) * | 1988-02-12 | 1988-03-09 | Zambeletti Spa L | Compounds |
| FR2627491B1 (fr) * | 1988-02-18 | 1992-01-24 | Roussel Uclaf | Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| US4855316A (en) * | 1988-02-18 | 1989-08-08 | Warner-Lambert Company | 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds |
| US5051428A (en) * | 1988-12-06 | 1991-09-24 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| EP0552386A1 (en) * | 1992-01-13 | 1993-07-28 | Warner-Lambert Company | 2-Amino-3 or 6-methoxycyclohexyl amide derivatives |
| ES2104142T3 (es) * | 1992-03-26 | 1997-10-01 | Univ British Columbia | Aminociclohexilamidas para utilizacion antirritmica y anestesica. |
| US5506257A (en) * | 1992-03-26 | 1996-04-09 | University Of British Columbia | Aminocyclohexylamides for antiarrhythmic and anaesthetic uses |
| AU7650294A (en) | 1993-09-24 | 1995-04-10 | University Of British Columbia, The | Aminocyclohexylesters and uses thereof |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6750216B2 (en) | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| AU3384697A (en) * | 1996-07-24 | 1998-02-10 | Warner-Lambert Company | Diphenyl-cyclopropenes as selective k-agonists |
| AU6878298A (en) * | 1997-04-30 | 1998-11-24 | Warner-Lambert Company | Peripherally selective kappa opioid agonists |
| CA2326777C (en) * | 1998-04-01 | 2011-12-20 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
| US7053087B1 (en) | 1999-03-04 | 2006-05-30 | Cardiome Pharma Corp. | Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| AU2002211828A1 (en) * | 2000-10-02 | 2002-04-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| BRPI0318278B8 (pt) * | 2003-05-02 | 2024-01-09 | Cardiome Pharma Corp | Compostos de éter aminocicloexílico, composição compreendendo ditos compostos, usos dos mesmos e método para modular a atividade do canal iônico em um ambiente in vitro |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| US7674820B2 (en) * | 2003-08-07 | 2010-03-09 | Cardiome Pharma Corp. | Ion channel modulating activity I |
| US7378409B2 (en) * | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| JP5583325B2 (ja) * | 2004-11-08 | 2014-09-03 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物の投与レジメ |
| CN102046612A (zh) | 2008-06-02 | 2011-05-04 | 希普拉有限公司 | 合成左旋西替利嗪的方法和其中所用的中间体 |
| KR101157936B1 (ko) * | 2009-11-30 | 2012-06-22 | 정종헌 | 마그네틱 교반기의 믹서구조 |
| MX340819B (es) | 2010-06-29 | 2016-07-26 | Poniard Pharmaceuticals Inc * | Formulacion oral de inhibidores de quinasa. |
| WO2012012139A1 (en) * | 2010-06-30 | 2012-01-26 | Poniard Pharmaceuticals, Inc. | Synthesis and use of kinase inhibitors |
| CN102731316B (zh) * | 2012-05-21 | 2014-04-16 | 南通市华峰化工有限责任公司 | 一种1，2-n，n`二甲基环己二胺的生产方法 |
| CN111410647B (zh) * | 2019-01-04 | 2021-08-17 | 中国人民解放军军事科学院军事医学研究院 | μ阿片受体偏向性激动剂及其医药用途 |
| AU2019427489A1 (en) | 2019-01-28 | 2021-07-22 | Mitochondria Emotion, Inc. | Mitofusin activators and methods of use thereof |
| CA3127453A1 (en) | 2019-01-28 | 2020-08-06 | Mitochondria Emotion, Inc. | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
| US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
-
1984
- 1984-11-13 US US06/669,922 patent/US4656182A/en not_active Expired - Fee Related
- 1984-11-23 CA CA000468526A patent/CA1234808A/en not_active Expired
- 1984-11-26 IL IL73632A patent/IL73632A/xx unknown
- 1984-11-27 IE IE3037/84A patent/IE57673B1/en not_active IP Right Cessation
- 1984-11-30 AU AU36080/84A patent/AU565236B2/en not_active Ceased
- 1984-12-03 FI FI844751A patent/FI80031C/fi not_active IP Right Cessation
- 1984-12-03 EP EP84308360A patent/EP0147085B1/en not_active Expired - Lifetime
- 1984-12-03 DE DE8484308360T patent/DE3481614D1/de not_active Expired - Fee Related
- 1984-12-04 ES ES538243A patent/ES538243A0/es active Granted
- 1984-12-04 GR GR81174A patent/GR81174B/el unknown
- 1984-12-04 DK DK576184A patent/DK576184A/da not_active Application Discontinuation
- 1984-12-05 NO NO844853A patent/NO165838C/no unknown
- 1984-12-05 NZ NZ210440A patent/NZ210440A/xx unknown
- 1984-12-05 PH PH31534A patent/PH21740A/en unknown
- 1984-12-05 HU HU844524A patent/HU200162B/hu not_active IP Right Cessation
- 1984-12-06 OA OA58462A patent/OA07885A/xx unknown
- 1984-12-06 KR KR1019840007723A patent/KR880002532B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI844751A0 (fi) | 1984-12-03 |
| KR880002532B1 (ko) | 1988-11-28 |
| NO165838B (no) | 1991-01-07 |
| NO844853L (no) | 1985-06-07 |
| PH21740A (en) | 1988-02-10 |
| US4656182A (en) | 1987-04-07 |
| HU200162B (en) | 1990-04-28 |
| CA1234808A (en) | 1988-04-05 |
| FI80031C (fi) | 1990-04-10 |
| IL73632A0 (en) | 1985-02-28 |
| ES8602599A1 (es) | 1985-12-01 |
| FI80031B (fi) | 1989-12-29 |
| DE3481614D1 (de) | 1990-04-19 |
| IE57673B1 (en) | 1993-02-24 |
| FI844751L (fi) | 1985-06-07 |
| AU565236B2 (en) | 1987-09-10 |
| EP0147085A2 (en) | 1985-07-03 |
| NZ210440A (en) | 1989-01-06 |
| IE843037L (en) | 1985-06-06 |
| KR850004757A (ko) | 1985-07-27 |
| OA07885A (en) | 1986-11-20 |
| EP0147085A3 (en) | 1987-02-04 |
| HUT36777A (en) | 1985-10-28 |
| EP0147085B1 (en) | 1990-03-14 |
| DK576184A (da) | 1985-06-07 |
| AU3608084A (en) | 1985-06-13 |
| NO165838C (no) | 1991-04-17 |
| GR81174B (en) | 1985-04-05 |
| ES538243A0 (es) | 1985-12-01 |
| IL73632A (en) | 1988-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |