FI841651A0 - Foerfarande foer framstaellning av acemetacin. - Google Patents
Foerfarande foer framstaellning av acemetacin.Info
- Publication number
- FI841651A0 FI841651A0 FI841651A FI841651A FI841651A0 FI 841651 A0 FI841651 A0 FI 841651A0 FI 841651 A FI841651 A FI 841651A FI 841651 A FI841651 A FI 841651A FI 841651 A0 FI841651 A0 FI 841651A0
- Authority
- FI
- Finland
- Prior art keywords
- acemetacin
- frequency framing
- acidic conditions
- protecting group
- framing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Soil Working Implements (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58075869A JPS59204172A (ja) | 1983-04-28 | 1983-04-28 | アセメタシンの製造法 |
JP7586983 | 1983-04-28 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI841651A0 true FI841651A0 (fi) | 1984-04-26 |
FI841651A FI841651A (fi) | 1984-10-29 |
FI78467B FI78467B (fi) | 1989-04-28 |
FI78467C FI78467C (fi) | 1989-08-10 |
Family
ID=13588693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI841651A FI78467C (fi) | 1983-04-28 | 1984-04-26 | Foerfarande foer framstaellning av acemetacin. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4603210A (fi) |
EP (1) | EP0126942B1 (fi) |
JP (1) | JPS59204172A (fi) |
KR (1) | KR910006125B1 (fi) |
AT (1) | ATE30020T1 (fi) |
AU (1) | AU562759B2 (fi) |
CA (1) | CA1331602C (fi) |
DE (1) | DE3466535D1 (fi) |
DK (1) | DK157539C (fi) |
ES (1) | ES531924A0 (fi) |
FI (1) | FI78467C (fi) |
GR (1) | GR81853B (fi) |
IE (1) | IE57288B1 (fi) |
PH (1) | PH20577A (fi) |
PT (1) | PT78477B (fi) |
ZA (1) | ZA843151B (fi) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH653326A5 (de) * | 1981-12-28 | 1985-12-31 | Siegfried Ag | Verfahren zur herstellung eines indolderivates. |
DE3416895A1 (de) * | 1984-05-08 | 1985-11-14 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von acemetacin |
DE3443993A1 (de) * | 1984-12-01 | 1986-06-05 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von neuen indolderivaten und deren verwendung |
FI88500C (fi) * | 1991-11-18 | 1993-05-25 | Orion Yhtymae Oy | Foerfarande foer framstaellning av 1-(p-klorbensoyl)-5-metoxi-2-metylindol-3-aettiksyra karboximetylester |
US7989554B2 (en) | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
CN111960986A (zh) * | 2019-05-19 | 2020-11-20 | 河南东泰制药有限公司 | 一种阿西美辛的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA837084A (en) * | 1970-03-17 | Sletzinger Meyer | Method for preparing indolylacetic acid esters | |
GB1176348A (en) * | 1966-01-12 | 1970-01-01 | Sumitomo Chemical Co | Indole Derivatives |
US3564008A (en) * | 1967-01-14 | 1971-02-16 | Sumitomo Chemical Co | Process for preparing 1-acyl-2-phenyl-3-indolylaliphatic acid derivatives |
US3483220A (en) * | 1967-05-03 | 1969-12-09 | Merck & Co Inc | Process for preparing 1-aroylindole-3-acetic acid compounds |
DE2234651C3 (de) * | 1972-07-14 | 1978-11-09 | Troponwerke Gmbh & Co Kg, 5000 Koeln | Eckige Klammer auf l-(p-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol] -acetoxj essigsaure, ihre Salze mit Basen, Verfahren zu ihrer Herstellung sowie pharmakologische Zubereitungen |
US4104278A (en) * | 1972-11-25 | 1978-08-01 | Troponwerke Dinklage & Co. | Process for the production of compounds with antiphlogistic activity |
GB1531546A (en) * | 1976-05-19 | 1978-11-08 | Pierrel Spa | Anti-inflammatory indole derivative |
JPS52156862A (en) * | 1976-06-22 | 1977-12-27 | Hisamitsu Pharmaceut Co Inc | Novel indoleacetic acid ester derivatives |
DE2735537A1 (de) * | 1977-08-06 | 1979-02-22 | Troponwerke Gmbh & Co Kg | Indolacetoxyacetylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
IT1144692B (it) * | 1981-04-03 | 1986-10-29 | Unibios Spa | Nuovo procedimento per la preparazione dell'acido 1-p-clorobenzoil-2-metil-5-metossi-2-indolacetoidrossammico |
CH653326A5 (de) * | 1981-12-28 | 1985-12-31 | Siegfried Ag | Verfahren zur herstellung eines indolderivates. |
DE3206885A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1983
- 1983-04-28 JP JP58075869A patent/JPS59204172A/ja active Granted
-
1984
- 1984-03-26 GR GR74206A patent/GR81853B/el unknown
- 1984-04-11 US US06/599,096 patent/US4603210A/en not_active Expired - Lifetime
- 1984-04-12 PH PH30612A patent/PH20577A/en unknown
- 1984-04-16 DE DE8484104281T patent/DE3466535D1/de not_active Expired
- 1984-04-16 AT AT84104281T patent/ATE30020T1/de not_active IP Right Cessation
- 1984-04-16 EP EP84104281A patent/EP0126942B1/en not_active Expired
- 1984-04-17 AU AU27005/84A patent/AU562759B2/en not_active Ceased
- 1984-04-24 PT PT78477A patent/PT78477B/pt unknown
- 1984-04-26 ES ES531924A patent/ES531924A0/es active Granted
- 1984-04-26 FI FI841651A patent/FI78467C/fi not_active IP Right Cessation
- 1984-04-26 CA CA000452849A patent/CA1331602C/en not_active Expired - Fee Related
- 1984-04-27 DK DK212484A patent/DK157539C/da not_active IP Right Cessation
- 1984-04-27 ZA ZA843151A patent/ZA843151B/xx unknown
- 1984-04-27 IE IE1050/84A patent/IE57288B1/en not_active IP Right Cessation
- 1984-04-27 KR KR1019840002272A patent/KR910006125B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2700584A (en) | 1984-11-01 |
DK157539B (da) | 1990-01-22 |
PT78477B (pt) | 1986-05-27 |
EP0126942B1 (en) | 1987-09-30 |
JPH0557265B2 (fi) | 1993-08-23 |
EP0126942A1 (en) | 1984-12-05 |
KR910006125B1 (ko) | 1991-08-13 |
JPS59204172A (ja) | 1984-11-19 |
AU562759B2 (en) | 1987-06-18 |
CA1331602C (en) | 1994-08-23 |
DE3466535D1 (en) | 1987-11-05 |
FI841651A (fi) | 1984-10-29 |
DK157539C (da) | 1990-06-11 |
PT78477A (en) | 1984-05-01 |
FI78467C (fi) | 1989-08-10 |
ATE30020T1 (de) | 1987-10-15 |
FI78467B (fi) | 1989-04-28 |
DK212484D0 (da) | 1984-04-27 |
IE841050L (en) | 1984-10-28 |
ES8603821A1 (es) | 1986-01-01 |
KR840008320A (ko) | 1984-12-14 |
IE57288B1 (en) | 1992-07-15 |
ZA843151B (en) | 1984-12-24 |
GR81853B (fi) | 1984-12-12 |
US4603210A (en) | 1986-07-29 |
DK212484A (da) | 1984-10-29 |
ES531924A0 (es) | 1986-01-01 |
PH20577A (en) | 1987-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: TROPONWERKE GMBH & CO., KG Owner name: KOWA COMPANY, LIMITED |