ES531924A0 - Un procedimiento para la preparacion de acemetacina - Google Patents

Un procedimiento para la preparacion de acemetacina

Info

Publication number
ES531924A0
ES531924A0 ES531924A ES531924A ES531924A0 ES 531924 A0 ES531924 A0 ES 531924A0 ES 531924 A ES531924 A ES 531924A ES 531924 A ES531924 A ES 531924A ES 531924 A0 ES531924 A0 ES 531924A0
Authority
ES
Spain
Prior art keywords
acemetacine
procedure
preparation
acemetacin
acidic conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES531924A
Other languages
English (en)
Other versions
ES8603821A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Kowa Co Ltd
Original Assignee
Troponwerke GmbH
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH, Kowa Co Ltd filed Critical Troponwerke GmbH
Publication of ES8603821A1 publication Critical patent/ES8603821A1/es
Publication of ES531924A0 publication Critical patent/ES531924A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Soil Working Implements (AREA)
ES531924A 1983-04-28 1984-04-26 Un procedimiento para la preparacion de acemetacina Granted ES531924A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58075869A JPS59204172A (ja) 1983-04-28 1983-04-28 アセメタシンの製造法

Publications (2)

Publication Number Publication Date
ES8603821A1 ES8603821A1 (es) 1986-01-01
ES531924A0 true ES531924A0 (es) 1986-01-01

Family

ID=13588693

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531924A Granted ES531924A0 (es) 1983-04-28 1984-04-26 Un procedimiento para la preparacion de acemetacina

Country Status (16)

Country Link
US (1) US4603210A (es)
EP (1) EP0126942B1 (es)
JP (1) JPS59204172A (es)
KR (1) KR910006125B1 (es)
AT (1) ATE30020T1 (es)
AU (1) AU562759B2 (es)
CA (1) CA1331602C (es)
DE (1) DE3466535D1 (es)
DK (1) DK157539C (es)
ES (1) ES531924A0 (es)
FI (1) FI78467C (es)
GR (1) GR81853B (es)
IE (1) IE57288B1 (es)
PH (1) PH20577A (es)
PT (1) PT78477B (es)
ZA (1) ZA843151B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH653326A5 (de) * 1981-12-28 1985-12-31 Siegfried Ag Verfahren zur herstellung eines indolderivates.
DE3416895A1 (de) * 1984-05-08 1985-11-14 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von acemetacin
DE3443993A1 (de) * 1984-12-01 1986-06-05 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von neuen indolderivaten und deren verwendung
FI88500C (fi) * 1991-11-18 1993-05-25 Orion Yhtymae Oy Foerfarande foer framstaellning av 1-(p-klorbensoyl)-5-metoxi-2-metylindol-3-aettiksyra karboximetylester
US7989554B2 (en) 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
CN111960986A (zh) * 2019-05-19 2020-11-20 河南东泰制药有限公司 一种阿西美辛的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA837084A (en) * 1970-03-17 Sletzinger Meyer Method for preparing indolylacetic acid esters
GB1176348A (en) * 1966-01-12 1970-01-01 Sumitomo Chemical Co Indole Derivatives
US3564008A (en) * 1967-01-14 1971-02-16 Sumitomo Chemical Co Process for preparing 1-acyl-2-phenyl-3-indolylaliphatic acid derivatives
US3483220A (en) * 1967-05-03 1969-12-09 Merck & Co Inc Process for preparing 1-aroylindole-3-acetic acid compounds
DE2234651C3 (de) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln Eckige Klammer auf l-(p-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol] -acetoxj essigsaure, ihre Salze mit Basen, Verfahren zu ihrer Herstellung sowie pharmakologische Zubereitungen
US4104278A (en) * 1972-11-25 1978-08-01 Troponwerke Dinklage & Co. Process for the production of compounds with antiphlogistic activity
GB1531546A (en) * 1976-05-19 1978-11-08 Pierrel Spa Anti-inflammatory indole derivative
JPS52156862A (en) * 1976-06-22 1977-12-27 Hisamitsu Pharmaceut Co Inc Novel indoleacetic acid ester derivatives
DE2735537A1 (de) * 1977-08-06 1979-02-22 Troponwerke Gmbh & Co Kg Indolacetoxyacetylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1144692B (it) * 1981-04-03 1986-10-29 Unibios Spa Nuovo procedimento per la preparazione dell'acido 1-p-clorobenzoil-2-metil-5-metossi-2-indolacetoidrossammico
CH653326A5 (de) * 1981-12-28 1985-12-31 Siegfried Ag Verfahren zur herstellung eines indolderivates.
DE3206885A1 (de) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
KR910006125B1 (ko) 1991-08-13
EP0126942A1 (en) 1984-12-05
ZA843151B (en) 1984-12-24
EP0126942B1 (en) 1987-09-30
IE841050L (en) 1984-10-28
IE57288B1 (en) 1992-07-15
FI78467C (fi) 1989-08-10
DK157539C (da) 1990-06-11
JPH0557265B2 (es) 1993-08-23
FI841651A (fi) 1984-10-29
GR81853B (es) 1984-12-12
JPS59204172A (ja) 1984-11-19
AU562759B2 (en) 1987-06-18
ES8603821A1 (es) 1986-01-01
PT78477B (pt) 1986-05-27
DK212484D0 (da) 1984-04-27
FI78467B (fi) 1989-04-28
DK212484A (da) 1984-10-29
PH20577A (en) 1987-02-18
DK157539B (da) 1990-01-22
DE3466535D1 (en) 1987-11-05
PT78477A (en) 1984-05-01
CA1331602C (en) 1994-08-23
KR840008320A (ko) 1984-12-14
AU2700584A (en) 1984-11-01
US4603210A (en) 1986-07-29
ATE30020T1 (de) 1987-10-15
FI841651A0 (fi) 1984-04-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051011