FI81577B - Foerfarande foer framstaellning av som laekemedel anvaendbara 2-(2-substituerad-2-iminoetyltio)-6-(1-hydroxietyl)- 1-karbapen -2-em-3-karboxylsyror. - Google Patents

Foerfarande foer framstaellning av som laekemedel anvaendbara 2-(2-substituerad-2-iminoetyltio)-6-(1-hydroxietyl)- 1-karbapen -2-em-3-karboxylsyror. Download PDF

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Publication number
FI81577B
FI81577B FI861763A FI861763A FI81577B FI 81577 B FI81577 B FI 81577B FI 861763 A FI861763 A FI 861763A FI 861763 A FI861763 A FI 861763A FI 81577 B FI81577 B FI 81577B
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FI
Finland
Prior art keywords
group
multiplet
mixture
solution
formula
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FI861763A
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English (en)
Finnish (fi)
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FI861763A0 (fi
FI861763A (fi
FI81577C (sv
Inventor
Masayuki Iwata
Isao Kawamoto
Rokuro Endo
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Sankyo Co
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Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI861763A0 publication Critical patent/FI861763A0/fi
Publication of FI861763A publication Critical patent/FI861763A/fi
Publication of FI81577B publication Critical patent/FI81577B/fi
Application granted granted Critical
Publication of FI81577C publication Critical patent/FI81577C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Claims (4)

1 Patentkrav Förfarande för framställning av som läkemedel användbara 2-(2-substi-tuerad-2-iminoetyltio)-6-(l-hydroxietyl)-l-karbapen-2-em-3-karboxyl-5 syror med formeln NH OH X II ie i jf S-CH2-C-Y chh—nr (i> J—H-lv
0 COOH 15 där: 20. aveer en väteatom eller en metylgrupp; och Y avser en grupp med formeln: '"'-li* -O·*·"1 30 där: Z avser en syreatom eller tvi väteatomer; R avser en väteatom eller en C^-C^-alkylgrupp, 35 avser en väteatom eller en hydroxlgrupp, och 3 R avser en karbamoylgrupp; 70 81 577 1 eller
2 R avser en karbamoyloxigrupp, och
3 R avser en väteatom eller en karbamoylgrupp; L 5. avser en väteatom eller en C^-C^-alkylgrupp; och 9 avser en 1-pyrrolidinyl- eller 1-plperidlnylgrupp; 1C eller ett farmaceutlekt acceptabelt salt eller en ester därav, k Μ n -netecknat därav, att förfarandet innefattar fbljande steg: (a) man läter en fbrenlng med formeln 15 OH X <-n, IT 20 8 (där X är tidlgare deflnierad, R avser en alkylsulfonyloxigrupp, en fenylsulfonylgrupp, en difenylfosfonyloxigrupp eller en grupp med formeln 25 0 t -sf" 30 (där R^ är fenyl, en p-nltrobensylgrupp eller en motsvarande 1 och för slg känd skyddande grupp) reagera med en merkaptan med formeln (IV) NH hs-ch2-c-y (IV) II 35 7i 81577 ^ (där Y Mr definierad tidigare) för att fl en förening med formeln e OH X f 0,3 ΓΠΤ „ (v) 1C (där R^,X och Y Mr definierade tidigare); 9 efter vilket man valbart avlägsnar den karboxiskyddande gruppen R 15 frln nMmnda förening med formeln (V) för att fä en förening med nämnda formel (I). 20 25 30 35
FI861763A 1985-04-27 1986-04-25 Förfarande för framställning av som läkemedel användbara 2-(2-substitu erad-2-iminoetyltio)-6-(1-hydroxietyl)-1-karbapen-2-em-3-karboxylsyror FI81577C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9198885 1985-04-27
JP9198885 1985-04-27

Publications (4)

Publication Number Publication Date
FI861763A0 FI861763A0 (fi) 1986-04-25
FI861763A FI861763A (fi) 1986-10-28
FI81577B true FI81577B (fi) 1990-07-31
FI81577C FI81577C (sv) 1990-11-12

Family

ID=14041841

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861763A FI81577C (sv) 1985-04-27 1986-04-25 Förfarande för framställning av som läkemedel användbara 2-(2-substitu erad-2-iminoetyltio)-6-(1-hydroxietyl)-1-karbapen-2-em-3-karboxylsyror

Country Status (17)

Country Link
US (1) US4771046A (sv)
EP (1) EP0202048B1 (sv)
JP (1) JPH0710868B2 (sv)
KR (1) KR920010076B1 (sv)
AT (1) ATE69053T1 (sv)
AU (1) AU583113B2 (sv)
CA (1) CA1305709C (sv)
DE (1) DE3682225D1 (sv)
DK (1) DK189686A (sv)
ES (1) ES8800952A1 (sv)
FI (1) FI81577C (sv)
HU (1) HU194882B (sv)
IE (1) IE58892B1 (sv)
NO (1) NO163452C (sv)
NZ (1) NZ215957A (sv)
PH (1) PH22555A (sv)
ZA (1) ZA863109B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0759581B2 (ja) * 1986-09-05 1995-06-28 日本レダリ−株式会社 （１ｒ）−１−メチルカルバペネム−３−カルボン酸誘導体
JPS6425780A (en) * 1987-04-28 1989-01-27 Sankyo Co 1-methylcarbapenem derivative
NO178498C (no) * 1990-02-23 1996-04-10 Sankyo Co Analogifremgangsmåte ved fremstilling av terapeutisk aktive karbapenemderivater
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
CN1046729C (zh) 1994-09-16 1999-11-24 万有制药株式会社 新的碳代青霉烯衍生物
CA2199855A1 (en) * 1994-09-16 1996-03-21 Ryosuke Ushijima Novel carbapenem derivative
US5932048A (en) * 1995-04-06 1999-08-03 Komatsu Electronic Metals Co., Ltd. Method of fabricating direct-bonded semiconductor wafers
US20070234661A1 (en) * 2005-01-28 2007-10-11 Ed Vaes Multi piece curved moldings

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
EP0060612A1 (en) * 1981-02-04 1982-09-22 Beecham Group Plc Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives
ES514240A0 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
JPS60178888A (ja) * 1984-02-22 1985-09-12 Sankyo Co Ltd ペネムまたはカルバペネム誘導体およびその製法

Also Published As

Publication number Publication date
NO861630L (no) 1986-10-28
ATE69053T1 (de) 1991-11-15
ES554474A0 (es) 1987-12-01
KR920010076B1 (ko) 1992-11-13
JPS6230781A (ja) 1987-02-09
JPH0710868B2 (ja) 1995-02-08
DK189686D0 (da) 1986-04-24
NO163452B (no) 1990-02-19
NO163452C (no) 1990-05-30
FI861763A0 (fi) 1986-04-25
EP0202048B1 (en) 1991-10-30
AU583113B2 (en) 1989-04-20
PH22555A (en) 1988-10-17
NZ215957A (en) 1988-04-29
ES8800952A1 (es) 1987-12-01
US4771046A (en) 1988-09-13
DE3682225D1 (de) 1991-12-05
CA1305709C (en) 1992-07-28
AU5671086A (en) 1986-10-30
ZA863109B (en) 1986-12-30
FI861763A (fi) 1986-10-28
IE861106L (en) 1986-10-27
EP0202048A1 (en) 1986-11-20
IE58892B1 (en) 1993-12-01
KR860008178A (ko) 1986-11-12
HUT40661A (en) 1987-01-28
HU194882B (en) 1988-03-28
DK189686A (da) 1986-10-28
FI81577C (sv) 1990-11-12

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Owner name: SANKYO COMPANY LIMITED