FI77670B - Metallkomplexer av aspartam-soetningsmedel och kompositioner som innehaoller dessa. - Google Patents
Metallkomplexer av aspartam-soetningsmedel och kompositioner som innehaoller dessa. Download PDFInfo
- Publication number
- FI77670B FI77670B FI830726A FI830726A FI77670B FI 77670 B FI77670 B FI 77670B FI 830726 A FI830726 A FI 830726A FI 830726 A FI830726 A FI 830726A FI 77670 B FI77670 B FI 77670B
- Authority
- FI
- Finland
- Prior art keywords
- complex
- apm
- sweetener
- compound according
- metal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/801—Peptide sweetners
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Seasonings (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Parts Printed On Printed Circuit Boards (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Organic Insulating Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Claims (19)
1. Metallkomplex av aspartara(APM)-sötningsmedel, kännetecknat därav, att det har formeln: 5 H2N-CH-CONH-CH-COO(CH3).pMm+.sQt_ ch2cooh I 10 (ch2)ph vari a) den stereokemiska konfigurationen är DL-DL, DL-L, L-DL eller L-L, 15 b) Ph är en fenylring, c) m och t är heltalen 1-3, d) p är förhällandet mellan metallen Mm+ och dipeptidsöt-ningsmedlet och har ett värde mellan 0,1-3,0, e) s är förhällandet anjonen till dipeptidsötnings- 20 medlet, varvid p x m = s x t, f) m”+ är en farmakologiskt godtagbar metalljon, före- 2 + 24- 2+ 3+ 2 + 3 + trädesvis Ca^ , Znz , Mg , A1 , Fe eller Fe , eller en kombination av farmakologiskt godtagbara me- talljoner, 25 g) Qt_ är en halogenid eller en kombination därav, och h) metallkomplexet av dipeptidsötningsmedlet kan vara hydratiserat eller ohydratiserat.
2. Förening enligt patentkravet 1, känne- t e c k n a d därav, att Mm+ är en kombination av farma-30 kologiskt godtagbara metalljoner.
3. Förening enligt patentkravet 2, känne- 2+ 2 + t e c k n a d därav, att den är APM-Ca Zn -hybrid-komplex.
4. Förening enligt patentkravet 1, känne -35 tecknad därav, att Mm+ är en farmakologiskt godtagbar metalljon. I! 13 77670
5. Förening enligt patentkravet 4, känne-t e c kna d därav, att Q är Cl.
6. Förening enligt patentkravet 5, kanne- 2+ t e c k n a d därav, att den är ett APM-Ca -komplex. 5
7. Förening enligt patentkravet 5, k ä n n e - 3+ t e c k n a d därav, att den är ett APM-Fe -komplex.
8. Förening enligt patentkravet 5, k ä n n e - 2+ t e c k n a d därav, att den är ett APM-Mg -komplex.
9. Förening enligt patentkravet 5, kanne- 3+ 10 tecknad därav, att den är ett APM-A1 -komplex.
10. Förening enligt patentkravet 5, k ä n n e - 2+ tecknad därav, att den är ett APM-Zn -komplex.
11. Metallkomplex av aspartam-sötningsmedlet enligt patentkravet 1, kännetecknad därav, att det 15 ytterligare omfattar ett farmakologiskt godtagbart starkt kelateringsmedel.
12. Förening enligt patentkravet 11, k ä n n e -tecknad därav, att mängden kelateringsmedel utgör 0,5-10 vikt-% av metallkomplexet av aspartam-sötnings- 20 medlet.
13. Förening enligt patentkravet 12, kännetecknad därav, att kelateringsmedlet är EDTA-di-natriumsalt.
14. Vätskeartad, kalorifattigt sötningsmedel, 25 kännetecknad därav, att det innehäller ett metallkomplex av aspartam med formeln: H-N-CH-CONH-CH-COO(CH_).pMm+.sQt_ CH-COOH 30 Δ (CH2)Ph väri a) den stereokemiska konfigurationen är DL-DL, DL-L, L-DL eller L-L, 35 b) Ph är en fenylring, c) m och t är heltalen 1-3,
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35457482 | 1982-03-04 | ||
| US06/354,574 US4448716A (en) | 1982-03-04 | 1982-03-04 | Dipeptide sweetener-metal complexes |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI830726A0 FI830726A0 (fi) | 1983-03-03 |
| FI830726L FI830726L (fi) | 1983-09-05 |
| FI77670B true FI77670B (fi) | 1988-12-30 |
| FI77670C FI77670C (sv) | 1989-04-10 |
Family
ID=23393964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI830726A FI77670C (sv) | 1982-03-04 | 1983-03-03 | Metallkomplexer av aspartam-sötningsmedel och kompositioner som inneh åller dessa. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4448716A (sv) |
| EP (1) | EP0088367B1 (sv) |
| JP (1) | JPS58162262A (sv) |
| AT (1) | ATE15752T1 (sv) |
| AU (1) | AU551602B2 (sv) |
| CA (1) | CA1248297A (sv) |
| DE (1) | DE3360859D1 (sv) |
| DK (1) | DK157724C (sv) |
| ES (1) | ES8504672A1 (sv) |
| FI (1) | FI77670C (sv) |
| GR (1) | GR77939B (sv) |
| IE (1) | IE54591B1 (sv) |
| IL (1) | IL68035A0 (sv) |
| NO (1) | NO161500C (sv) |
| NZ (1) | NZ203455A (sv) |
| PT (1) | PT76333B (sv) |
| ZA (1) | ZA831481B (sv) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692512A (en) * | 1984-07-13 | 1987-09-08 | The Procter & Gamble Company | Alpha-L-aspartyl-D-phenylglycine esters and amides useful as high intensity sweeteners |
| EP0204826A4 (en) * | 1984-12-11 | 1989-02-09 | Patrick Joseph Joyce | THERMOSTABLE PEPTIDE SWEETENERS. |
| US4676989A (en) * | 1984-12-27 | 1987-06-30 | General Foods Corporation | Sweetening with cycloalkyl ethers and thioethers of dipeptides |
| EP0186173A3 (en) * | 1984-12-27 | 1988-08-10 | General Foods Corporation | L-aminodicarboxylic-(0-cycloalkyl)-l-aminocarboxylate alkyl esters, an edible composition containing same as sweeteners and a method for sweetening an edible composition |
| WO1986003944A1 (en) * | 1985-01-03 | 1986-07-17 | Joyce Patrick J | Heat stabilized peptide table salt substitutes |
| US4701552A (en) * | 1985-05-06 | 1987-10-20 | General Foods Corporation | L-aminodicarboxylic acid alkanes |
| US4634792A (en) * | 1985-05-06 | 1987-01-06 | General Foods Corporation | L-aminodicarboxylic acid aminoalkenoic acid ester amides |
| JPS63500634A (ja) * | 1985-08-09 | 1988-03-10 | ザ ユニバ−シティ− オブ ジョ−ジア リサ−チ ファウンデ−ション、インコ−ポレ−テッド | 安定化されたペプチド甘味料 |
| US4663519A (en) * | 1985-09-09 | 1987-05-05 | At&T Company | Wound coil products and manufacture thereof |
| US4692513A (en) * | 1985-12-20 | 1987-09-08 | The Procter & Gamble Company | Alpha-L-aspartyl-D-heteroaromatic-substituted glycine esters and amides useful as high intensity sweeteners |
| US4830716B1 (en) * | 1986-07-03 | 1999-12-07 | Albion Int | Preparation of pharmaceutical grade amino acid chelates |
| AU600176B2 (en) * | 1987-10-13 | 1990-08-02 | Mitsui Toatsu Chemicals Inc. | Preparation method of alpha-l-aspartyl-l-phenylalanine methyl ester having improved solubilization |
| US4849541A (en) * | 1987-11-13 | 1989-07-18 | General Foods Corporation | Process for the preparation of N-L-aminodicarboxylic acid esters and new compositions used in the preparation thereof |
| DE3831717A1 (de) * | 1988-09-17 | 1990-03-22 | Basf Ag | Verfahren zur herstellung von dipeptiden mit n-terminalen nicht-proteinogenen aminosaeuren |
| EP0386963B1 (en) * | 1989-03-08 | 1994-12-28 | Pfizer Inc. | Preventing off-flavor in certain alitame-sweetened beverages |
| JPH062582A (ja) * | 1992-04-15 | 1994-01-11 | Nippondenso Co Ltd | 内燃機関の燃料噴射装置 |
| GB2273130B (en) * | 1992-12-07 | 1995-12-13 | Nippon Denso Co | Fuel injection system for multi-cylinder internal combustion engine |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| US6180156B1 (en) | 1997-09-11 | 2001-01-30 | The Nutrasweet Company | Acid salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| US6146680A (en) * | 1997-09-11 | 2000-11-14 | The Nutrasweet Company | Metal complexes of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| US6129942A (en) * | 1997-09-11 | 2000-10-10 | The Nutrasweet Company | Sweetener salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| US20030008047A1 (en) * | 2000-03-17 | 2003-01-09 | Schroeder Steve A. | Stability enhancement of sweeteners using salts containing divalent or trivalent cations |
| CN101531702B (zh) * | 2008-12-22 | 2011-12-21 | 华南理工大学 | 含卤素超甜二肽化合物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3492131A (en) * | 1966-04-18 | 1970-01-27 | Searle & Co | Peptide sweetening agents |
| US4029701A (en) * | 1972-03-30 | 1977-06-14 | General Foods Corporation | Sweetening with hydrohalide salts of dipeptide sweeteners |
| US4031258A (en) * | 1972-03-30 | 1977-06-21 | General Foods Corporation | Inorganic salts of dipeptide sweeteners |
| GB1431057A (en) * | 1972-03-30 | 1976-04-07 | Gen Foods Corp | Sweetining compositions |
| US4031259A (en) * | 1975-08-13 | 1977-06-21 | General Foods Corporation | Process of preparing nutritive sweetening compositions |
| US4122195A (en) * | 1977-01-24 | 1978-10-24 | General Foods Corporation | Fixation of APM in chewing gum |
-
1982
- 1982-03-04 US US06/354,574 patent/US4448716A/en not_active Expired - Lifetime
-
1983
- 1983-03-03 FI FI830726A patent/FI77670C/sv not_active IP Right Cessation
- 1983-03-03 CA CA000422792A patent/CA1248297A/en not_active Expired
- 1983-03-03 NO NO830727A patent/NO161500C/no unknown
- 1983-03-03 IL IL68035A patent/IL68035A0/xx not_active IP Right Cessation
- 1983-03-03 AT AT83102070T patent/ATE15752T1/de not_active IP Right Cessation
- 1983-03-03 EP EP83102070A patent/EP0088367B1/en not_active Expired
- 1983-03-03 PT PT76333A patent/PT76333B/pt not_active IP Right Cessation
- 1983-03-03 ES ES520274A patent/ES8504672A1/es not_active Expired
- 1983-03-03 DK DK108083A patent/DK157724C/da not_active IP Right Cessation
- 1983-03-03 GR GR70662A patent/GR77939B/el unknown
- 1983-03-03 AU AU12013/83A patent/AU551602B2/en not_active Ceased
- 1983-03-03 DE DE8383102070T patent/DE3360859D1/de not_active Expired
- 1983-03-03 IE IE459/83A patent/IE54591B1/en not_active IP Right Cessation
- 1983-03-03 NZ NZ203455A patent/NZ203455A/en unknown
- 1983-03-04 JP JP58035714A patent/JPS58162262A/ja active Pending
- 1983-03-04 ZA ZA831481A patent/ZA831481B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES520274A0 (es) | 1985-04-16 |
| IE830459L (en) | 1983-09-04 |
| NO161500C (no) | 1989-08-23 |
| NO830727L (no) | 1983-09-05 |
| DK157724C (da) | 1990-07-16 |
| PT76333B (en) | 1985-11-28 |
| IE54591B1 (en) | 1989-12-06 |
| JPS58162262A (ja) | 1983-09-26 |
| ES8504672A1 (es) | 1985-04-16 |
| ATE15752T1 (de) | 1985-10-15 |
| IL68035A0 (en) | 1983-06-15 |
| ZA831481B (en) | 1984-04-25 |
| PT76333A (en) | 1983-04-01 |
| GR77939B (sv) | 1984-09-25 |
| CA1248297A (en) | 1989-01-03 |
| DE3360859D1 (en) | 1985-10-31 |
| DK108083D0 (da) | 1983-03-03 |
| AU1201383A (en) | 1983-09-08 |
| FI830726A0 (fi) | 1983-03-03 |
| EP0088367A1 (en) | 1983-09-14 |
| NZ203455A (en) | 1985-12-13 |
| AU551602B2 (en) | 1986-05-08 |
| US4448716A (en) | 1984-05-15 |
| FI830726L (fi) | 1983-09-05 |
| DK157724B (da) | 1990-02-12 |
| NO161500B (no) | 1989-05-16 |
| EP0088367B1 (en) | 1985-09-25 |
| FI77670C (sv) | 1989-04-10 |
| DK108083A (da) | 1983-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: G D SEARLE & CO. |