FI76798B - Foerfarande foer framstaellning av terapeutiskt anvaendbara hexahydropyrrolo/2,1-a/isokinolinderivat. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara hexahydropyrrolo/2,1-a/isokinolinderivat. Download PDFInfo
- Publication number
- FI76798B FI76798B FI842533A FI842533A FI76798B FI 76798 B FI76798 B FI 76798B FI 842533 A FI842533 A FI 842533A FI 842533 A FI842533 A FI 842533A FI 76798 B FI76798 B FI 76798B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- carbon atoms
- compounds
- isoquinoline
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Detergent Compositions (AREA)
Claims (4)
1. Förfarande för framställning av terapeutiskt an-vändbara hexahydropyrroloZJ, l-a7isokinolinderivat med for-5 mein (I) samt diastereomerer och icke-toxiska, farmaceu-tiskt godtagbara syraadditionssalter därav, \ R2 15. vilken formel är väte eller lägre alkyl med 1-4 kol-atomer; R2 är väte, lägre alkyl med 1-4 kolatomer, fluor, hydroxi eller lägre alkoxi med 1-4 kolatomer; Rg och R? är antingen lika eller olika och betekcnar väte, 20 lägre alkyl med 1-4 kolatomer, lägre alkoxi med 1-4 kolatomer, hydroxi eller halogen eller tillsammans bildar metylen-dioxid; och A är en grupp med formeln (1) eller (3) te-- o- (1) (3) 30 varvid i bensenringen med formeln (1) betecknar Rg och Rg väte, perfluor(lägre)alkyl med 1-4 kolatomer, hydroxi, lägre alkoxi med 1-4 kolatomer, lägre acylamino med 1-5 kolatomer, bensoylamino, cyano, karboxiamido, lägre alkyl-tio med 1-5 kolatomer, lägre-alkylsulfonyl med 1-4 kolato-35 mer, nitro* aminp, läcjrealkyl- eller di(lägre)alkyl-amino, som innehäller 1-4 kolatomer i varje alkyl, eller halogen; II 43 76798 och varvid i cykloalkylringen med formeln (3) n = 0-2, och grupperna med formler (1) och (3) kan vara bundna via vilken som heist kolatom i ringen, kännetecknat därav, att man 5 i) reducerar en laktam med formeln (IV-A) A v 1^2 _
10. Rx I_I eller ii) reducerar en laktam med formeln (XIV-A) » *' H UIV"A' 20 eller iii) för framställning av föreningar med formeln (I), där R2 är väte, cykliserar en aminoalkohol med formeln (XVII-A) HU p VV’ VV -N (XVII-A) 30 eller iv) för framställning av föreningar med formeln (I), där är väte, reducerar ett iminiumsalt med formeln (XIX-A)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50725083A | 1983-06-23 | 1983-06-23 | |
US50725083 | 1983-06-23 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI842533A0 FI842533A0 (fi) | 1984-06-21 |
FI842533A FI842533A (fi) | 1984-12-24 |
FI76798B true FI76798B (fi) | 1988-08-31 |
FI76798C FI76798C (sv) | 1988-12-12 |
Family
ID=24017860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI842533A FI76798C (sv) | 1983-06-23 | 1984-06-21 | Förfarande för framställning av terapeutiskt användbara hexahydropyrro lo/2,1-a/isokinolinderivat |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0130069B1 (sv) |
JP (1) | JPS6069082A (sv) |
KR (1) | KR910002564B1 (sv) |
AT (1) | ATE59041T1 (sv) |
AU (1) | AU563990B2 (sv) |
CA (1) | CA1253155A (sv) |
DE (1) | DE3483735D1 (sv) |
DK (1) | DK305184A (sv) |
ES (1) | ES8602676A1 (sv) |
FI (1) | FI76798C (sv) |
HK (1) | HK54891A (sv) |
HU (1) | HU193937B (sv) |
NO (1) | NO164474C (sv) |
NZ (1) | NZ208480A (sv) |
SG (1) | SG44391G (sv) |
ZA (1) | ZA844402B (sv) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4572911A (en) * | 1984-08-02 | 1986-02-25 | Mcneilab, Inc. | Hexahydroindolinzine compounds, pharmaceutical compositions and methods and intermediates |
DE3717395A1 (de) * | 1987-05-23 | 1988-12-08 | Basf Ag | 5-phenyl-1,2,3a,4,5,9b-hexahydro-3h-benz(e) indole, ihre herstellung und verwendung als arzneimittel |
GB8718980D0 (en) * | 1987-08-11 | 1987-09-16 | May & Baker Ltd | Compositions of matter |
GB9326699D0 (en) * | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
WO2006138604A1 (en) | 2005-06-17 | 2006-12-28 | Janssen Pharmaceutica N.V. | Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE690792A (sv) * | 1966-12-07 | 1967-05-16 | ||
CH527194A (de) * | 1970-01-06 | 1972-08-31 | Hoffmann La Roche | Verfahren zur Herstellung von Isochinolin-Derivaten |
-
1984
- 1984-06-11 ZA ZA844402A patent/ZA844402B/xx unknown
- 1984-06-12 NZ NZ208480A patent/NZ208480A/en unknown
- 1984-06-12 NO NO842345A patent/NO164474C/no unknown
- 1984-06-14 CA CA000456578A patent/CA1253155A/en not_active Expired
- 1984-06-21 FI FI842533A patent/FI76798C/sv not_active IP Right Cessation
- 1984-06-22 EP EP84304247A patent/EP0130069B1/en not_active Expired - Lifetime
- 1984-06-22 HU HU842443A patent/HU193937B/hu not_active IP Right Cessation
- 1984-06-22 DK DK305184A patent/DK305184A/da unknown
- 1984-06-22 AU AU29777/84A patent/AU563990B2/en not_active Ceased
- 1984-06-22 DE DE8484304247T patent/DE3483735D1/de not_active Expired - Fee Related
- 1984-06-22 ES ES533657A patent/ES8602676A1/es not_active Expired
- 1984-06-22 AT AT84304247T patent/ATE59041T1/de not_active IP Right Cessation
- 1984-06-23 JP JP59129917A patent/JPS6069082A/ja active Pending
- 1984-06-23 KR KR1019840003577A patent/KR910002564B1/ko not_active IP Right Cessation
-
1991
- 1991-06-14 SG SG44391A patent/SG44391G/en unknown
- 1991-07-18 HK HK548/91A patent/HK54891A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU563990B2 (en) | 1987-07-30 |
FI842533A0 (fi) | 1984-06-21 |
JPS6069082A (ja) | 1985-04-19 |
NO164474B (no) | 1990-07-02 |
FI76798C (sv) | 1988-12-12 |
ES533657A0 (es) | 1985-10-01 |
AU2977784A (en) | 1985-01-03 |
HK54891A (en) | 1991-07-26 |
FI842533A (fi) | 1984-12-24 |
CA1253155A (en) | 1989-04-25 |
HUT34478A (en) | 1985-03-28 |
SG44391G (en) | 1991-07-26 |
KR850000440A (ko) | 1985-02-27 |
DK305184D0 (da) | 1984-06-22 |
EP0130069B1 (en) | 1990-12-12 |
NZ208480A (en) | 1986-08-08 |
KR910002564B1 (ko) | 1991-04-26 |
NO842345L (no) | 1984-12-27 |
NO164474C (no) | 1990-10-10 |
ZA844402B (en) | 1986-01-29 |
EP0130069A2 (en) | 1985-01-02 |
ES8602676A1 (es) | 1985-10-01 |
DK305184A (da) | 1984-12-24 |
EP0130069A3 (en) | 1985-09-11 |
DE3483735D1 (en) | 1991-01-24 |
ATE59041T1 (de) | 1990-12-15 |
HU193937B (en) | 1987-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI78464B (fi) | Foerfarande foer framstaellning av farmakologiskt vaerdefulla 1-benzyl-aminoalkylpyrrolidinoner. | |
JPS5874673A (ja) | 三環式エ−テル化合物及びその製法並びに該化合物を有効成分とする製剤 | |
JPH04506071A (ja) | 中枢神経系活性を有する複素環系アミン | |
DK161968B (da) | Analogifremgangsmaade til fremstilling af imidazo-pyrazolo-pyrimidiner eller farmaceutisk acceptable salte deraf | |
US4125726A (en) | Imidazo[1,5-a][1,4]benzodiazepines | |
FI76798B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara hexahydropyrrolo/2,1-a/isokinolinderivat. | |
US4595688A (en) | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof | |
JPH02184687A (ja) | 新規化合物、その製法及びそれを含む医薬組成物 | |
CZ2000320A3 (cs) | Deriváty 4-oxo-3,5dihydro-4H-pyridazino[4,5-b]indol-1-acetamidu a farmaceutický prostředek, který je obsahuje | |
NO167737B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydroimidazo(1,4)benzodiazepin-2-oner. | |
Hall et al. | Quinoline derivatives as antiallergy agents. 2. Fused-ring quinaldic acids | |
FI71936B (fi) | Foerfarande foer framstaellning av neuroleptiskt aktiva 2-substituerade-8-fluor-5-(4-fluorfenyl)-2,3,4,4a 5,9b-hexahydro-4a 9b-trans-1h-pyrido/4,3-b/indolderivat | |
El-Gaml | Application of chalcone in synthesis of new heterocycles containing 1, 5-benzodiazepine derivatives | |
Jiang et al. | α-Cyclization of tertiary amines. Part 1 | |
US4268513A (en) | Pyrrolo [3,4-c]quinoline compounds and pharmaceutical compositions, methods for their use and preparation | |
US4719216A (en) | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants | |
CA1133483A (en) | Hexahydro-trans-pyridoindole neuroleptic agents | |
Abd El-Aal et al. | Friedel-Crafts chemistry. Part 40. An expedient novel synthesis of some dibenz-azepines,-azocines, 11H-benzo [f] pyrido [2, 3-b] azepines and 6H-benzo [g] pyrido [2, 3-c] azocines. | |
Nagarajan et al. | Condensed heterotricycles: Pyrrolo [l, 2-α] quinoxaline derivatives | |
Diaz et al. | Unlocking the synthetic potential of aziridine and cyclopropane-fused quinolin-2-ones by regioselective fragmentation of its three-membered rings | |
Puodziunaite et al. | On the synthetic way to novel peri-annelated imidazo [1, 5] benzodiazepinones as the potent non-nucleoside reverse transcriptase inhibitors | |
US4166185A (en) | Imidazo[1,5-α][1,4]benzodiazepines | |
Wang et al. | Concise synthesis of benzoindolizidine derivatives and bioactivity evaluation | |
Martin et al. | (.+-.)-4-Aryl-4, 5-dihydro-3H-1, 3-benzodiazepines. 2. Nuclear substituted analogs of (.+-.)-4, 5-dihydro-2, 3-dimethyl-4-phenyl-3H-1, 3-benzodiazepine and (.+-.)-4, 5-dihydro-2-ethyl-3-methyl-4-phenyl-3H-1, 3-benzodiazepine as potential antidepressant agents | |
DK156391B (da) | Analogifremgangsmaade til fremstilling af 3-aminopyrrolderivater |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: MCNEIL PHARMACEUTICAL |