FI76087B - Foerfarande foer framstaellning av terapeutiskt aktiva 9-(2-hydroxietoximetyl)guaninderivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva 9-(2-hydroxietoximetyl)guaninderivat. Download PDF

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Publication number
FI76087B
FI76087B FI832355A FI832355A FI76087B FI 76087 B FI76087 B FI 76087B FI 832355 A FI832355 A FI 832355A FI 832355 A FI832355 A FI 832355A FI 76087 B FI76087 B FI 76087B
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FI
Finland
Prior art keywords
formula
sup
compounds
compound
sub
Prior art date
Application number
FI832355A
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English (en)
Finnish (fi)
Other versions
FI76087C (sv
FI832355L (fi
FI832355A0 (fi
Inventor
Clercq Erik Desire Alice De
Haeghe Hubert Jean Henr Vander
Roger Honore Cornelius Busson
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI832355A0 publication Critical patent/FI832355A0/fi
Publication of FI832355L publication Critical patent/FI832355L/fi
Publication of FI76087B publication Critical patent/FI76087B/fi
Application granted granted Critical
Publication of FI76087C publication Critical patent/FI76087C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (3)

1. Förfarande för framställning av terapeutiskt akti va föreningar med den allmänna formeIn
5 OH H-N ^ 10 2 ch2och2ch2or3 3 väri R är en aminosyraacylradikal, och farmakologiskt godtagbara salter därav, kännetecknat därav, 15 att man omsätter en förening med formeln R1 Γ .. N \ II 20 ,ΛΛ./ CH2OCH2CH2OH 25 1 4 väri R är en eventuellt skyddad hydroxigrupp, och R ar en eventuellt skyddad aminogrupp, med en eventuellt skyddad aminosyra eller med en funktionell ekvivalent därav, och vid behov utför en eller flera av följande reaktioner 30 i vilken önskad ordning som heist: i) avlägsnar skyddsgrupperna; ii) dä den erhällna produkten är en förening med formeln I, omvandlar denna tili ett farmakologiskt god-tagbart sait därav; och 35 iii) dä den erhällna produkten är ett farmakolo giskt godtagbart sait av en förening med formeln I, omvandlar detta tili ett förening med formeln I.
FI832355A 1982-06-29 1983-06-28 Förfarande för framställning av terapeutiskt aktiva 9-(2-hydroxietoxim etyl)guaninderivat FI76087C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8202626 1982-06-29
NL8202626A NL8202626A (nl) 1982-06-29 1982-06-29 Derivaten van 9-(2-hydroxyethoxymethyl)guanine.

Publications (4)

Publication Number Publication Date
FI832355A0 FI832355A0 (fi) 1983-06-28
FI832355L FI832355L (fi) 1983-12-30
FI76087B true FI76087B (fi) 1988-05-31
FI76087C FI76087C (sv) 1988-09-09

Family

ID=19839947

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832355A FI76087C (sv) 1982-06-29 1983-06-28 Förfarande för framställning av terapeutiskt aktiva 9-(2-hydroxietoxim etyl)guaninderivat

Country Status (13)

Country Link
US (1) US4548819A (sv)
EP (1) EP0099493B1 (sv)
JP (1) JPS5910587A (sv)
AT (1) ATE45580T1 (sv)
CA (1) CA1208637A (sv)
DE (1) DE3380410D1 (sv)
DK (1) DK159444C (sv)
FI (1) FI76087C (sv)
GB (1) GB2122618B (sv)
HU (1) HU189709B (sv)
IL (1) IL69095A (sv)
MY (1) MY102248A (sv)
NL (1) NL8202626A (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
GB8725939D0 (en) * 1987-11-05 1987-12-09 Wellcome Found Therapeutic compounds
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
IT1223604B (it) * 1987-12-24 1990-09-29 Co Pharma Corp Srl Derivati purinici ad azione farmacologica
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
CA2005815C (en) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Antiviral acyclic nucleoside derivatives
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
US5451799A (en) * 1992-12-28 1995-09-19 Matsushita Electric Industrial Co., Ltd. MOS transistor for protection against electrostatic discharge
EP0702682B1 (en) * 1993-06-10 2001-03-14 Rolabo Sl Process for the preparation of amino acid esters of nucleoside analogues
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (sv) * 1993-11-18 1996-08-01 Ajinomoto Kk
DE69513313T2 (de) * 1994-02-01 2000-07-13 Ajinomoto Kk Verfahren zur Herstellung von Nukleinsäurebasenderivaten
US5994361A (en) * 1994-06-22 1999-11-30 Biochem Pharma Substituted purinyl derivatives with immunomodulating activity
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
WO1997027198A1 (en) * 1996-01-26 1997-07-31 F.Hoffmann-La Roche Ag Process for preparing purine derivatives
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
AU2002365234B2 (en) 2001-12-14 2009-01-29 Pharmasset Inc N4-acylcytosine nucleosides for treatment of viral infections
US20070293517A1 (en) * 2004-06-09 2007-12-20 Ramot At Tel Aviv University Ltd. Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety
ATE546451T1 (de) 2005-05-25 2012-03-15 Lilly Co Eli Cyclopropancarbonsäureester von acyclovir

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
JPS52105195A (en) * 1976-03-01 1977-09-03 Wellcome Found Substituted purine
AU515553B2 (en) * 1976-03-01 1981-04-09 The Wellcome Foundation Limited Purine derivatives

Also Published As

Publication number Publication date
JPH04990B2 (sv) 1992-01-09
DE3380410D1 (en) 1989-09-21
GB2122618A (en) 1984-01-18
US4548819A (en) 1985-10-22
MY102248A (en) 1992-05-15
EP0099493B1 (en) 1989-08-16
FI76087C (sv) 1988-09-09
IL69095A (en) 1985-11-29
DK297483D0 (da) 1983-06-28
DK159444B (da) 1990-10-15
FI832355L (fi) 1983-12-30
FI832355A0 (fi) 1983-06-28
ATE45580T1 (de) 1989-09-15
DK297483A (da) 1983-12-30
GB2122618B (en) 1985-11-13
GB8317504D0 (en) 1983-08-03
HU189709B (en) 1986-07-28
NL8202626A (nl) 1984-01-16
CA1208637A (en) 1986-07-29
DK159444C (da) 1991-03-18
IL69095A0 (en) 1983-10-31
EP0099493A1 (en) 1984-02-01
JPS5910587A (ja) 1984-01-20

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Owner name: THE WELLCOME FOUNDATION LIMITED