FI74711B - Foerfarande foer framstaellning av terapeutiskt anvaendbara cykliska hexapeptidfoereningar. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara cykliska hexapeptidfoereningar. Download PDF

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Publication number
FI74711B
FI74711B FI803306A FI803306A FI74711B FI 74711 B FI74711 B FI 74711B FI 803306 A FI803306 A FI 803306A FI 803306 A FI803306 A FI 803306A FI 74711 B FI74711 B FI 74711B
Authority
FI
Finland
Prior art keywords
phe
trp
lys
thr
cyclo
Prior art date
Application number
FI803306A
Other languages
English (en)
Finnish (fi)
Other versions
FI74711C (sv
FI803306L (fi
Inventor
Daniel F Veber
Roger M Freidinger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/089,827 external-priority patent/US4235886A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI803306L publication Critical patent/FI803306L/fi
Application granted granted Critical
Publication of FI74711B publication Critical patent/FI74711B/fi
Publication of FI74711C publication Critical patent/FI74711C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Claims (7)

1. Förfarande för framställning av en terapeutiskt användbar cyklisk hexapeptidförening med formeln 5
0 R2 H VS * V’’
10 CHa h ° / 0=4 I O H
1. R4 0 eller 20 O R- H c/Yir"
25. M n
0. N-H irVV^
30. R4 väri X är (CHn) , väri n är 0, 1 eller 2, 2 n' Y är (CH„) , väri m är 0, 1 eller 2, eller svavel, sä 2. m 35 att svavel kan vara i vilket ställe som heist i kedjan, R^ och R2 är oberoende av varandra bensyl eller substi-tuerad bensyl, väri substituenten kan vara 1 eller 2 ha-logener eller hydroxigrupper, är 3-indolylmetyl eller substituerad 3-indolylmetyl, 40 väri substituenten kan vara lägre alkoxi eller halogen,
FI803306A 1979-10-31 1980-10-21 Förfarande för framställning av terapeutiskt användbara cykliska hexap eptidföreningar. FI74711C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8982879A 1979-10-31 1979-10-31
US8982879 1979-10-31
US8982779 1979-10-31
US06/089,827 US4235886A (en) 1979-10-31 1979-10-31 Cyclic hexapeptide somatostatin analogs

Publications (3)

Publication Number Publication Date
FI803306L FI803306L (fi) 1981-05-01
FI74711B true FI74711B (fi) 1987-11-30
FI74711C FI74711C (sv) 1988-03-10

Family

ID=26780979

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803306A FI74711C (sv) 1979-10-31 1980-10-21 Förfarande för framställning av terapeutiskt användbara cykliska hexap eptidföreningar.

Country Status (17)

Country Link
EP (1) EP0029310B1 (sv)
KR (1) KR860001961B1 (sv)
AU (1) AU540140B2 (sv)
CA (1) CA1216844A (sv)
DD (1) DD153684A5 (sv)
DE (1) DE3064499D1 (sv)
DK (1) DK152505C (sv)
ES (1) ES8202787A1 (sv)
FI (1) FI74711C (sv)
GR (1) GR70725B (sv)
IE (1) IE50364B1 (sv)
NO (1) NO150958C (sv)
NZ (1) NZ195303A (sv)
PL (1) PL128347B1 (sv)
PT (1) PT71966B (sv)
RO (1) RO81523A (sv)
YU (1) YU278780A (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
US4374060A (en) * 1981-07-15 1983-02-15 Merck & Co., Inc. Process for the preparation of cyclic hexapeptide
US4427661A (en) * 1982-07-30 1984-01-24 Merck & Co., Inc. Fluorinated cyclic hexapeptide somatostatin analogs
DE3379657D1 (en) * 1982-12-06 1989-05-24 Merck & Co Inc Dicyclic hexapeptides, processes for their preparation and pharmaceutical compositions containing them
DE3303345A1 (de) * 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Cyclische peptide mit somatostatin-wirkung
US4505897A (en) * 1983-04-18 1985-03-19 The Administrators Of The Tulane Educational Fund Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
EP1099707A3 (en) * 1993-06-23 2002-01-09 Diatide, Inc. Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
MY147327A (en) 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7708136L (sv) * 1976-08-02 1978-02-03 Merck & Co Inc Cykliska hexapeptider
EP0000053B1 (en) * 1977-06-08 1981-05-27 Merck & Co. Inc. Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden

Also Published As

Publication number Publication date
AU6358180A (en) 1981-05-07
KR830004223A (ko) 1983-07-09
DD153684A5 (de) 1982-01-27
ES496424A0 (es) 1982-02-16
ES8202787A1 (es) 1982-02-16
DK460580A (da) 1981-05-01
DK152505B (da) 1988-03-07
NO803245L (no) 1981-05-04
EP0029310A1 (en) 1981-05-27
RO81523B (ro) 1983-07-30
RO81523A (ro) 1983-08-03
FI74711C (sv) 1988-03-10
DK152505C (da) 1988-07-25
PT71966B (en) 1982-03-31
IE50364B1 (en) 1986-04-02
YU278780A (en) 1983-01-21
PT71966A (en) 1980-11-01
NZ195303A (en) 1984-10-19
DE3064499D1 (en) 1983-09-08
NO150958C (no) 1985-01-16
IE802224L (en) 1981-04-30
EP0029310B1 (en) 1983-08-03
GR70725B (sv) 1983-01-18
PL128347B1 (en) 1984-01-31
FI803306L (fi) 1981-05-01
NO150958B (no) 1984-10-08
CA1216844A (en) 1987-01-20
PL227577A1 (sv) 1981-10-02
KR860001961B1 (ko) 1986-11-05
AU540140B2 (en) 1984-11-01

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Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: MERCK & CO., INC.