FI68245B - Foerfarande foer framstaellning av terapeutiskt aktiva polypeptidderivat eller syraadditionssalter daerav - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva polypeptidderivat eller syraadditionssalter daerav Download PDFInfo
- Publication number
- FI68245B FI68245B FI793002A FI793002A FI68245B FI 68245 B FI68245 B FI 68245B FI 793002 A FI793002 A FI 793002A FI 793002 A FI793002 A FI 793002A FI 68245 B FI68245 B FI 68245B
- Authority
- FI
- Finland
- Prior art keywords
- arg
- ser
- ala
- formula
- leu
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (5)
1. Analogiförfarande för framställning av ett polypeptid-derivat som verkar hämmande pä den glukosstimulerade insulin-sekretionen och förstärkande pä glukosomsättningen och som har den allmänna formeln a-x-b-arg-c väri x betecknar glu eller asp, a betecknar väte eller en mindre skyddsgrupp för a-amino-gruppen i x, b betecknar leu eller en di- eller tripeptid vald ur den grupp som bestar av leu-ser, ser-ala, his-phe och gly-gly-gly och när x är glu, kan b dessutom beteckna en bindning eller ett sekretinfragment leu-ser-arg-leu eller leu-ser-arg-leu-arg- asp-ser-ala, och när x är asp, kan b dessutom beteckna sekretin- fragmentet ser-ala-arg-leu-glu, och 12 1 2 c betecknar -NR R , väri R och R är väte eller C^-C^-alkyl, eller 3 3 c betecknar -OR , väri R är väte eller C.-C,-alkyl, varvid 3 16 R icke kan vara väte när x är asp och b är ser-ala, eller syraadditionssalter därav, kännetecknat av att ett argininderivat med formeln arg-c, väri c har ovan angivna betydelse, eller ett skyddat derivat därav, kopplas med en förening med formeln a-x-b, väri a, x och b har ovan angivna betydelse, eller successivt med de i föreningen a-x-b ingäende enkia aminosyrorna eller peptidsekvenserna, varvid de funktionella grupper som icke skall reagera under syntesen, är skyddade, varefter en bildad peptid, om sä önskas, överförs i ett syra- additionssalt, eller om c är -OH, omsättes en bildad peptid, om sä önskas, med en amin med formeln R R NH eller med en 3 12 3 alkohol med formeln R OH, i vilka forraler R , R och R har ovan angivna betydelse. 1 Analogiförfarande enligt patentkravet 1 för framställning av en förening med formeln asp-ser-ala-arg-c väri c har den i patentkravet 1 angivna betydelsen, kanne-tecknatav att ett argininderivat med formeln arg-c, väri 68245 19 c har ovan angivna betydelse eller ett skyddat derivat därav, kopplas successivt med aminosyrorna ala, ser och asp, varvid de funktionella grupper sora icke skall reagera under syntesen, är skyddade, varefter reaktionsprodukten vid behov eller om sa önskas, befrias frän skyddsgrupperna.
3. Analogiförfarande enligt patentkravet 2, k ä n n e -tecknat av att ett argininderivat med formeln (NO2)arg-c vari c har ovan angivna betydelse, omsättes med en förening med formeln BOC-ala-ONO, varefter den bildade foreningen med formeln no9 BOC-ala-arg-c efter avspaltning av BOC-gruppen omsättes med BOC-(OBzl)-ser-ONO för bildande av en förening N0~ I ^ BOC-(OBzl)ser-ala-arg-c, som likaledes efter avspaltning av BOC-gruppen omsättes med en förening BOC-(3-Bzl)asp-0N0, varefter reaktionsprodukten med formeln BOC-(β-Bzl)asp-(OBzl)ser-ala-(NO2)arg-c hydreras till det önskade peptidderivatet.
4. Analogiförfarande enligt patentkravet 2 för framställning av ett peptidderivat med formeln g asp-ser-ala-arg-OR väri R6 är C^-C^-alkyl, kännetecknat av att mot-svarande peptid med formeln asp-ser-ala-arg-OH eller ett reaktivt derivat därav omsättes med en alkohol med formeln R^OH, vari R^ har ovan angivna betydelse, eller med ett reaktivt derivat därav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK430478 | 1978-09-28 | ||
| DK430478 | 1978-09-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI793002A FI793002A (fi) | 1980-03-29 |
| FI68245B true FI68245B (fi) | 1985-04-30 |
| FI68245C FI68245C (fi) | 1985-08-12 |
Family
ID=8132257
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI793002A FI68245C (fi) | 1978-09-28 | 1979-09-26 | Foerfarande foer framstaellning av terapeutiskt aktiva polypeptidderivat eller syraadditionssalter daerav |
| FI793001A FI68244C (fi) | 1978-09-28 | 1979-09-26 | Foerfarande foer framstaellning av terapeutiskt aktiva polypeptidderivat eller syraadditionssalter daerav |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI793001A FI68244C (fi) | 1978-09-28 | 1979-09-26 | Foerfarande foer framstaellning av terapeutiskt aktiva polypeptidderivat eller syraadditionssalter daerav |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4356119A (sv) |
| JP (2) | JPS5576849A (sv) |
| AT (1) | AT375338B (sv) |
| AU (2) | AU533684B2 (sv) |
| BE (2) | BE879087A (sv) |
| CA (2) | CA1158640A (sv) |
| CH (2) | CH648567A5 (sv) |
| DE (2) | DE2939135A1 (sv) |
| ES (2) | ES484928A1 (sv) |
| FI (2) | FI68245C (sv) |
| FR (2) | FR2437399A1 (sv) |
| GB (2) | GB2031436B (sv) |
| IT (2) | IT1125421B (sv) |
| NL (2) | NL7907188A (sv) |
| NO (2) | NO148922C (sv) |
| SE (2) | SE7907938L (sv) |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA798855A (en) * | 1968-11-12 | Bernardi Luigi | Process for preparing a new undecapeptide | |
| CA685075A (en) * | 1964-04-21 | Schwyzer Robert | Polypeptides and process for their manufacture | |
| CA616330A (en) * | 1961-03-14 | Schwyzer Robert | Polypeptide and derivatives thereof and process for their manfuacture | |
| GB1064417A (en) * | 1963-12-09 | 1967-04-05 | Kyowa Hakko Kogyo Kk | Process for the preparation of copolypeptides |
| US3400118A (en) * | 1966-05-27 | 1968-09-03 | Squibb & Sons Inc | Intermediates in the preparation of secretin |
| US3832337A (en) * | 1970-07-28 | 1974-08-27 | Squibb & Sons Inc | Peptide enzyme inhibitors |
| US3856770A (en) * | 1972-03-08 | 1974-12-24 | Akzona Inc | Psychopharmacologically active tetra-, penta-, hexa-, and heptapeptides |
| NL175174C (nl) * | 1972-03-31 | 1984-10-01 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat als actief bestanddeel bevat, alsmede een werkwijze ter bereiding van deze peptiden. |
| NL175988C (nl) * | 1972-05-24 | 1985-02-01 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat dat afgeleid is van een de aminozuren 4-10 omvattend, fragment van adrenocorticotroop hormoon als actief bestanddeel bevat, alsmede een werkwijze ter bereiding van deze peptiden. |
| NL175618C (nl) * | 1972-07-15 | 1984-12-03 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden. |
| DE2315271C3 (de) * | 1973-03-27 | 1975-09-11 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | L- Norleucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel |
| GB1532211A (en) * | 1974-10-25 | 1978-11-15 | Wellcome Found | Lh-rh peptide analogues |
| US3975365A (en) * | 1975-01-27 | 1976-08-17 | G. D. Searle & Co. | Inhibitory octapeptides angiotensin II |
| DE2602443A1 (de) * | 1975-04-04 | 1976-10-21 | Univ California | Biologisch aktive polypeptide |
| US4171299A (en) * | 1975-04-04 | 1979-10-16 | The Regents Of The University Of California | Polypeptide agents for blocking the human allergic response |
| US4058512A (en) * | 1975-04-28 | 1977-11-15 | Ab Kabi | Synthetic peptides having growth promoting activity |
| US4024121A (en) * | 1976-01-27 | 1977-05-17 | Schally Andrew Victor | (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates |
| SE436645C (sv) * | 1976-04-29 | 1996-07-22 | Bonnierfoeretagen Ab | Antigeniskt aktiv polypeptid, som kan användas vid cancerdiagnosticering och vid framställning av antikroppar |
| US4110321A (en) * | 1976-07-12 | 1978-08-29 | Folkers Karl | Synthetic tridecapeptide [Gln4 ]-neurotensin having hormonal activity |
| US4086220A (en) * | 1976-08-09 | 1978-04-25 | G. D. Searle & Co. | Fragments of secretin |
-
1979
- 1979-09-24 US US06/078,424 patent/US4356119A/en not_active Expired - Lifetime
- 1979-09-25 SE SE7907938A patent/SE7907938L/sv not_active Application Discontinuation
- 1979-09-25 SE SE7907939A patent/SE7907939L/sv not_active Application Discontinuation
- 1979-09-26 FI FI793002A patent/FI68245C/fi not_active IP Right Cessation
- 1979-09-26 AU AU51246/79A patent/AU533684B2/en not_active Ceased
- 1979-09-26 FI FI793001A patent/FI68244C/fi not_active IP Right Cessation
- 1979-09-26 AU AU51245/79A patent/AU526149B2/en not_active Ceased
- 1979-09-27 AT AT0634679A patent/AT375338B/de not_active IP Right Cessation
- 1979-09-27 FR FR7924077A patent/FR2437399A1/fr active Granted
- 1979-09-27 CA CA000336694A patent/CA1158640A/en not_active Expired
- 1979-09-27 NL NL7907188A patent/NL7907188A/nl not_active Application Discontinuation
- 1979-09-27 CA CA000336681A patent/CA1140116A/en not_active Expired
- 1979-09-27 CH CH8714/79A patent/CH648567A5/de not_active IP Right Cessation
- 1979-09-27 DE DE19792939135 patent/DE2939135A1/de not_active Withdrawn
- 1979-09-27 CH CH8715/79A patent/CH648568A5/de not_active IP Right Cessation
- 1979-09-27 NO NO793111A patent/NO148922C/no unknown
- 1979-09-27 DE DE19792939109 patent/DE2939109A1/de not_active Withdrawn
- 1979-09-27 GB GB7933541A patent/GB2031436B/en not_active Expired
- 1979-09-27 FR FR7924078A patent/FR2437400A1/fr active Granted
- 1979-09-27 NL NL7907187A patent/NL7907187A/nl not_active Application Discontinuation
- 1979-09-27 GB GB7933540A patent/GB2031435B/en not_active Expired
- 1979-09-27 NO NO793112A patent/NO148923C/no unknown
- 1979-09-28 JP JP12522179A patent/JPS5576849A/ja active Pending
- 1979-09-28 BE BE0/197392A patent/BE879087A/fr not_active IP Right Cessation
- 1979-09-28 ES ES484928A patent/ES484928A1/es not_active Expired
- 1979-09-28 ES ES484926A patent/ES484926A1/es not_active Expired
- 1979-09-28 JP JP12522079A patent/JPS5569550A/ja active Pending
- 1979-09-28 IT IT26111/79A patent/IT1125421B/it active
- 1979-09-28 BE BE0/197391A patent/BE879086A/fr not_active IP Right Cessation
- 1979-09-28 IT IT26112/79A patent/IT1125422B/it active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: NORDISK INSULINLABORATORIUM |