FI67654C - Foerfarande foer framstaellning av en rikligt alfa-lakta-albumin innehaollande produkt - Google Patents
Foerfarande foer framstaellning av en rikligt alfa-lakta-albumin innehaollande produkt Download PDFInfo
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- FI67654C FI67654C FI802010A FI802010A FI67654C FI 67654 C FI67654 C FI 67654C FI 802010 A FI802010 A FI 802010A FI 802010 A FI802010 A FI 802010A FI 67654 C FI67654 C FI 67654C
- Authority
- FI
- Finland
- Prior art keywords
- ultrafiltration
- whey
- membrane
- albumin
- lactalbumin
- Prior art date
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/833—Whey; cheese
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Water Supply & Treatment (AREA)
- Biochemistry (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Meat, Egg Or Seafood Products (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7916482A FR2459619B1 (fr) | 1979-06-26 | 1979-06-26 | Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede |
FR7916482 | 1979-06-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI802010A FI802010A (fi) | 1980-12-27 |
FI67654B FI67654B (fi) | 1985-01-31 |
FI67654C true FI67654C (fi) | 1985-05-10 |
Family
ID=9227124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI802010A FI67654C (fi) | 1979-06-26 | 1980-06-23 | Foerfarande foer framstaellning av en rikligt alfa-lakta-albumin innehaollande produkt |
Country Status (14)
Country | Link |
---|---|
US (2) | US4485040A (no) |
EP (1) | EP0022696B2 (no) |
JP (1) | JPS5636494A (no) |
AR (1) | AR222560A1 (no) |
AU (1) | AU538288B2 (no) |
BR (1) | BR8003973A (no) |
CA (1) | CA1136919A (no) |
DE (1) | DE3063675D1 (no) |
DK (1) | DK155907C (no) |
ES (1) | ES8201006A1 (no) |
FI (1) | FI67654C (no) |
FR (1) | FR2459619B1 (no) |
NO (1) | NO151567C (no) |
ZA (1) | ZA803748B (no) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59113848A (ja) * | 1982-12-20 | 1984-06-30 | Meiji Milk Prod Co Ltd | ホエ−又はホエ−蛋白濃縮物の精製法 |
GB2132466B (en) * | 1982-12-22 | 1986-10-15 | Impro Products Inc | Whey product and method for obtaining same |
US4834974A (en) * | 1986-01-13 | 1989-05-30 | Protein Technologies, Inc. | Immunologically active whey fraction and recovery process |
US4816252A (en) * | 1985-04-15 | 1989-03-28 | Protein Technology, Inc. | Product and process for transferring passive immunity to newborn domestic animals using ultrafiltered whey containing immunoglobulins |
FR2583267B1 (fr) * | 1985-06-17 | 1990-10-19 | Bridel Laiteries | Procede de separation des proteines du lactoserum |
JPS6283843A (ja) * | 1986-09-11 | 1987-04-17 | Meiji Milk Prod Co Ltd | 育児用調製乳 |
CA1297721C (en) * | 1987-01-26 | 1992-03-24 | Shalan A. Al-Mashiki | PROCESS FOR LOWERING THE CONCENTRATION OF .beta.-LACTOGLOBULIN IN CHEESE WHEY |
CH671879A5 (no) * | 1987-02-26 | 1989-10-13 | Nestle Sa | |
FR2611527A1 (fr) * | 1987-02-26 | 1988-09-09 | Sfec | Membrane inorganique d'ultrafiltration ou de microfiltration modifiee par un polymere hydrophile, son procede de preparation et son utilisation pour la separation de proteines |
AU616411B2 (en) * | 1987-05-14 | 1991-10-31 | Commonwealth Scientific And Industrial Research Organisation | Whey protein fractions |
GB8723651D0 (en) * | 1987-10-08 | 1987-11-11 | Express Foods Group Ltd | Process for containing concentrates |
DE3743440A1 (de) * | 1987-12-21 | 1989-06-29 | Gauri Kailash Kumar | Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch |
FI892006A (fi) * | 1988-04-29 | 1989-10-30 | Phil Gold | Lactalbumin saosom tillaeggsaemne i mat. |
US5230902A (en) * | 1988-04-29 | 1993-07-27 | Immunotec Research Corporation | Undenatured whey protein concentrate to improve active systemic humoral immune response |
US4897465A (en) * | 1988-10-12 | 1990-01-30 | Abbott Laboratories | Enrichment and concentration of proteins by ultrafiltration |
CA1338682C (en) * | 1988-12-23 | 1996-10-29 | Gustavo Bounous | Biologically active undenatured whey protein concentrate as food supplement |
US5204134A (en) * | 1989-01-13 | 1993-04-20 | Immuno Path Profile, Inc. | Hypoallergenic milk products from natural and/or synthetic components and process of making |
US5064674A (en) * | 1989-01-13 | 1991-11-12 | Immunopath Profile, Inc. | Hypoallergenic milk products and process of making |
US5116819A (en) * | 1989-05-05 | 1992-05-26 | Clintec Nutrition Co. | Enteral diet for patients with pulmonary disease |
FR2657013B1 (fr) * | 1990-01-18 | 1992-05-15 | Medgenix Group Sa | Composition dietetique a base de polypeptides et acides amines. |
US5219838A (en) * | 1990-07-09 | 1993-06-15 | Morinaga Milk Industry Co., Ltd. | Method for inhibiting tyrosinase activity in treatment of skin |
JP2961625B2 (ja) * | 1991-01-21 | 1999-10-12 | 雪印乳業株式会社 | α−ラクトアルブミン含有量の高い組成物の製造方法 |
JP3035833B2 (ja) * | 1991-01-21 | 2000-04-24 | 雪印乳業株式会社 | シアル酸類含有組成物の製造方法 |
JP3044487B2 (ja) * | 1991-02-28 | 2000-05-22 | 雪印乳業株式会社 | シアル酸類を含有しα−ラクトアルブミン含有量の高い組成物の製造方法 |
JPH05183457A (ja) * | 1992-01-07 | 1993-07-23 | Fujitsu Ltd | 無線受信機 |
JP2622789B2 (ja) * | 1992-02-18 | 1997-06-18 | 雪印乳業株式会社 | ホエーからα−ラクトアルブミン含有量の高い画分を製造する方法及び該画分を含有せしめてなる母乳代替物または栄養組成物 |
SE470375B (sv) * | 1992-05-07 | 1994-02-07 | Alfa Laval Food Eng Ab | Sätt att erhålla högvärdiga proteinprodukter ur vassle |
EP0604684B1 (en) | 1992-12-23 | 1997-06-11 | Campina Melkunie B.V. | Process for the recovery of alpha-lactalbumin and beta-lactoglobulin from a whey protein product |
US5310877A (en) * | 1993-04-08 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Method for separating serum albumin and gamma globulin |
US5470839A (en) * | 1993-04-22 | 1995-11-28 | Clintec Nutrition Company | Enteral diet and method for providing nutrition to a diabetic |
US5395636A (en) * | 1993-07-26 | 1995-03-07 | Pall Corporation | Method of pretreating a porous medium |
DE4344342C2 (de) * | 1993-12-23 | 1996-08-08 | Milupa Ag | Molkenprotein-dominante Säuglingsnahrung |
ZA949789B (en) * | 1993-12-30 | 1995-10-25 | Immunotec Res Corp Ltd | Process for making undenatured whey protein concentrate |
EP0686396B1 (fr) * | 1994-02-25 | 2000-09-27 | Societe Des Produits Nestle S.A. | Composition entérale comprenant de la caséine micellaire native |
EP0765125B1 (en) * | 1994-06-15 | 1999-01-27 | Dairygold Technologies Limited | Process for the fractionation of whey constituents |
EP0776214B1 (en) | 1994-08-16 | 1999-07-28 | Hemant Sabharwal | Antibacterial composition containing multimeric alpha-lactalbumin |
US5670196A (en) * | 1995-04-12 | 1997-09-23 | Galagen Inc. | Method for microfiltration of milk or colostral whey |
US5707678A (en) * | 1995-04-12 | 1998-01-13 | Galagen Inc. | Method for microfiltration of milk or colostral whey |
US6268487B1 (en) | 1996-05-13 | 2001-07-31 | Genzyme Transgenics Corporation | Purification of biologically active peptides from milk |
FR2754181B1 (fr) * | 1996-10-03 | 1998-12-04 | Oenobiol S A Lab | Nouvelles utilisations de compositions a base d'alpha-lactalbumine |
ES2296386T3 (es) * | 1998-04-23 | 2008-04-16 | Pro Dietic Rdp (S.A.R.L.) | Complemento proteinico, composicion alimenticia que lo contiene, su procedimiento de preparacion y su utilizacion. |
FR2777751B1 (fr) * | 1998-04-23 | 2001-11-02 | Pro Dietic Rdp | Complement proteique, composition alimentaire le contenant, leur procede de preparation et leur utilisation. |
US5948452A (en) * | 1998-08-31 | 1999-09-07 | Monte; Woodrow C. | Process for producing low pH by-products from waste products of cheese production |
GB9923048D0 (en) | 1999-09-29 | 1999-12-01 | Nestle Sa | Composition comprising casein protein and whey protein |
US6312755B1 (en) | 1999-07-16 | 2001-11-06 | Ampc | Whey treatment process for achieving high concentration of α-lactalbumin |
CA2408124A1 (en) * | 2000-05-05 | 2001-11-15 | Harry M. Meade | Transgenically produced decorin |
SE516838C2 (sv) * | 2000-06-16 | 2002-03-12 | Delaval Holding Ab | Metod och anordning för separering av mjölk |
US6423354B1 (en) | 2000-09-01 | 2002-07-23 | Woodrow C. Monte | Low pH antimicrobial food composition from total milk protein and process of manufacturing same |
KR100796853B1 (ko) * | 2000-12-06 | 2008-01-22 | 캄피나 쥐벨 베.붸. | 과량 트립토판 함유 펩티드의 제조방법 |
EP1228707A1 (en) * | 2001-02-01 | 2002-08-07 | Campina Melkunie B.V. | Use of alpha-lactalbumin as prebiotic agent |
US7651716B2 (en) * | 2001-12-21 | 2010-01-26 | Wyeth Llc | Methods for reducing adverse effects of feeding formula to infants |
US6913778B2 (en) * | 2001-12-21 | 2005-07-05 | Wyeth | Infant formula compositions comprising increased amounts of alpha-lactalbumin |
US20030166866A1 (en) * | 2002-01-28 | 2003-09-04 | Land O' Lakes, Inc. | Method of processing a proteinaceous material to recover K-casein macropeptide and polymers of a-lactalbumin and B-lactoglobulin |
US7285301B2 (en) | 2002-07-12 | 2007-10-23 | Entra-Safe, Inc. | Method for producing nutritionally balanced food compositions |
US6921548B2 (en) * | 2002-07-12 | 2005-07-26 | Entra-Safe, Inc. | Low pH food composition stabilization process |
WO2004050847A2 (en) * | 2002-11-27 | 2004-06-17 | Gtc Biotherapeutics, Inc. | Modified antibodies stably produced in milk and methods of producing same |
AU2004229176A1 (en) * | 2003-04-15 | 2004-10-28 | Campina B.V. | Method for producing a whey protein concentrate enriched in beta-lactoglobulin and texture enhancer based thereupon for use in dairy products |
US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
EP2388273B1 (en) * | 2005-10-21 | 2017-07-05 | LFB USA, Inc. | Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
WO2009134389A2 (en) * | 2008-05-01 | 2009-11-05 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatment of inflammatory conditions |
AU2010307432A1 (en) | 2009-10-12 | 2012-05-03 | Frieslandcampina Nederland Holding B.V. | Whey protein concentrate, its preparation and its use |
KR101166546B1 (ko) | 2009-11-20 | 2012-07-19 | 매일유업주식회사 | 유기태화 칼슘 함유량이 높은 유단백질의 제조방법 |
US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
KR20230037067A (ko) | 2016-07-06 | 2023-03-15 | 빌딩 블록 뉴트리셔널즈, 엘엘씨 | 영양 조제식 |
CA3037203A1 (en) * | 2016-09-19 | 2018-03-22 | Prolacta Bioscience, Inc. | Purified human milk oligosaccharides compositions |
US20210267231A1 (en) * | 2018-06-27 | 2021-09-02 | Arla Foods Amba | Novel method for preparing alpha-lactalbumin-enriched compositions, related products and uses e.g. in infant formulas |
IL299098A (en) | 2020-06-15 | 2023-02-01 | Building Block Nutritionals Llc | Nutritional formula |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2125137A1 (en) * | 1971-02-12 | 1972-09-29 | Genvrain Sa | Delactosed milk prepn - by ultra filtration of milk followed by inverse osmosis to separate lactose |
FR2239208B1 (no) * | 1973-07-31 | 1977-10-07 | Nestle Sa | |
US4036999A (en) * | 1974-08-30 | 1977-07-19 | Stauffer Chemical Company | Treatment of whey |
FR2288473A1 (fr) * | 1974-10-22 | 1976-05-21 | Manche Union Coop Agr Laiti | Procede de traitement du lactoserum de fromagerie, notamment en vue de l'extraction de glycoproteides et d'acide sialique |
US4163069A (en) * | 1977-10-11 | 1979-07-31 | Stauffer Chemical Company | Non-fat dry milk substitute product |
CH630243A5 (fr) * | 1978-05-11 | 1982-06-15 | Nestle Sa | Procede de recuperation des proteines du lactoserum. |
-
1979
- 1979-06-26 FR FR7916482A patent/FR2459619B1/fr not_active Expired
-
1980
- 1980-06-23 FI FI802010A patent/FI67654C/fi not_active IP Right Cessation
- 1980-06-24 EP EP80400945A patent/EP0022696B2/fr not_active Expired - Lifetime
- 1980-06-24 DE DE8080400945T patent/DE3063675D1/de not_active Expired
- 1980-06-24 ZA ZA00803748A patent/ZA803748B/xx unknown
- 1980-06-25 NO NO801903A patent/NO151567C/no unknown
- 1980-06-25 ES ES492753A patent/ES8201006A1/es not_active Expired
- 1980-06-25 BR BR8003973A patent/BR8003973A/pt unknown
- 1980-06-25 CA CA000354705A patent/CA1136919A/en not_active Expired
- 1980-06-25 DK DK273380A patent/DK155907C/da not_active IP Right Cessation
- 1980-06-26 AU AU59666/80A patent/AU538288B2/en not_active Ceased
- 1980-06-26 JP JP8719680A patent/JPS5636494A/ja active Granted
- 1980-06-28 AR AR281540A patent/AR222560A1/es active
-
1982
- 1982-01-08 US US06/338,136 patent/US4485040A/en not_active Expired - Lifetime
-
1986
- 1986-07-09 US US06/883,019 patent/US4711953A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI802010A (fi) | 1980-12-27 |
ES492753A0 (es) | 1981-11-01 |
NO151567C (no) | 1985-05-08 |
ES8201006A1 (es) | 1981-11-01 |
FR2459619B1 (fr) | 1983-07-29 |
EP0022696B2 (fr) | 1990-08-16 |
FR2459619A1 (fr) | 1981-01-16 |
US4711953A (en) | 1987-12-08 |
US4485040A (en) | 1984-11-27 |
DE3063675D1 (en) | 1983-07-14 |
DK273380A (da) | 1980-12-27 |
AU538288B2 (en) | 1984-08-09 |
FI67654B (fi) | 1985-01-31 |
JPS5636494A (en) | 1981-04-09 |
CA1136919A (en) | 1982-12-07 |
DK155907C (da) | 1989-10-16 |
AR222560A1 (es) | 1981-05-29 |
AU5966680A (en) | 1981-01-08 |
EP0022696B1 (fr) | 1983-06-08 |
NO151567B (no) | 1985-01-21 |
NO801903L (no) | 1980-12-29 |
DK155907B (da) | 1989-06-05 |
JPH0362720B2 (no) | 1991-09-26 |
EP0022696A1 (fr) | 1981-01-21 |
BR8003973A (pt) | 1981-01-13 |
ZA803748B (en) | 1981-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: CLINTEC NUTRITION COMPANY |
|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: CLINTEC NUTRITION COMPANY |