FI67370C - Mellanprodukt foer framstaellning av 4-(4-disubstituerade piperidinylmetyl)-3,3-difenyl-2-pyrrolidinoner och foerfarande foer framstaellning av mellanprodukten - Google Patents
Mellanprodukt foer framstaellning av 4-(4-disubstituerade piperidinylmetyl)-3,3-difenyl-2-pyrrolidinoner och foerfarande foer framstaellning av mellanprodukten Download PDFInfo
- Publication number
- FI67370C FI67370C FI762694A FI762694A FI67370C FI 67370 C FI67370 C FI 67370C FI 762694 A FI762694 A FI 762694A FI 762694 A FI762694 A FI 762694A FI 67370 C FI67370 C FI 67370C
- Authority
- FI
- Finland
- Prior art keywords
- diphenyl
- pyrrolidinone
- hydroxymethyl
- framstating
- mellan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Furan Compounds (AREA)
Claims (4)
1. Mellanprodukt för framställning av 4-(4-disubstituerade piperidinylmetyl)-3·,3-difenyl-2-pyrrolidinoner, känneteck-n a d av att mellanprodukten utgöres av en 1 -kolväte-3,3-difenyl- 4-(hydroximetyl eller halogenmetyl)-2-pyrrolidon med formeln C6H5 c6h5 --~ch2y ! I R väri R betecknar en lägre alkylgrupp med 1-6 kolatomer, lägre cykloalkylgrupp med 4-8 kolatomer eller fenyl-lägre alkylgrupp, vilken kan utgöras av tili exempel en bensyl-, fenetyl-, fenpropyl-eller a-metylbensylgrupp, och Y betecknar en hydroxylgrupp eller en halogenatom, med undantag av 4-klormetyl-3,3-difenyl-1-isopropyl-2-pyrrolidinon.
2. Mellanprodukt enligt patentkravet 1, kännetecknad av att den utgöres av 1-isopropyl-3,3-difenyl-4-hydroximetyl-2-pyrrolidinon.
3. Förfarande för framställning av 4-hydroximetyl-2-pyrrolidinon med formeln C6H5 CcH[- —I-r- CH OH o b 2 S IA i R väri R betecknar en lägre alkylgrupp med 1-6 kolatomer, lägre cykloalkylgrupp med 4-8 kolatomer eller fenyl-lägre alkylgrupp, vilken kan utgöras av tili exempel en bensyl-, fenetyl-, fenpropyl-eller α-metylbensylgrupp, kännetecknat av att en 4,5-dihydrofuran-2-(3H)on med formeln C H C6H5 f6 -5- CH2NHR O II
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI824104A FI76079C (sv) | 1975-09-23 | 1982-11-29 | 4,5-dihydro-3,3-difenyl-4-hydrokarbylaminometylfuran-2(3H)oner och för farande för deras framställning |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61595175 | 1975-09-23 | ||
| US05/615,951 US4119637A (en) | 1975-09-23 | 1975-09-23 | 4-Hydroxymethyl-2-pyrrolidinones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI762694A FI762694A (sv) | 1977-03-24 |
| FI67370B FI67370B (fi) | 1984-11-30 |
| FI67370C true FI67370C (fi) | 1985-03-11 |
Family
ID=24467444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI762694A FI67370C (fi) | 1975-09-23 | 1976-09-21 | Mellanprodukt foer framstaellning av 4-(4-disubstituerade piperidinylmetyl)-3,3-difenyl-2-pyrrolidinoner och foerfarande foer framstaellning av mellanprodukten |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4119637A (sv) |
| JP (2) | JPS6059228B2 (sv) |
| AU (2) | AU512445B2 (sv) |
| BE (1) | BE846402A (sv) |
| BR (1) | BR7606209A (sv) |
| CA (1) | CA1077497A (sv) |
| CH (1) | CH616659A5 (sv) |
| DE (2) | DE2642608A1 (sv) |
| DK (1) | DK160548C (sv) |
| ES (2) | ES451752A1 (sv) |
| FI (1) | FI67370C (sv) |
| FR (2) | FR2333792A1 (sv) |
| GB (2) | GB1552686A (sv) |
| IE (1) | IE44843B1 (sv) |
| IL (1) | IL50436A (sv) |
| MX (1) | MX3846E (sv) |
| NL (1) | NL7610526A (sv) |
| PH (1) | PH13940A (sv) |
| PT (1) | PT65624B (sv) |
| SE (1) | SE418397B (sv) |
| ZA (1) | ZA765417B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133881A (en) * | 1977-04-27 | 1979-01-09 | A. H. Robins Company, Incorporated | Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods |
| DE3326724A1 (de) * | 1983-07-25 | 1985-02-07 | Boehringer Ingelheim KG, 6507 Ingelheim | In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte |
| GB8419085D0 (en) * | 1984-07-26 | 1984-08-30 | Shell Int Research | Azetidine derivatives |
| DE3537075A1 (de) * | 1985-10-18 | 1987-04-23 | Bayer Ag | Verfahren zur herstellung von clausenamid |
| DE3823299A1 (de) * | 1988-07-07 | 1990-01-11 | Schering Ag | Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2650231A (en) * | 1949-11-19 | 1953-08-25 | Smith Kline French Lab | Aminovalerolactones and method for their production |
| JPS5422973B2 (sv) * | 1972-03-17 | 1979-08-10 | ||
| FR2235685A1 (en) * | 1973-06-20 | 1975-01-31 | Ugine Kuhlmann | 1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc. |
| ES442233A1 (es) * | 1974-11-06 | 1977-07-01 | Hoechst Ag | Procedimiento para la preparacion de pirrolidonas. |
-
1975
- 1975-09-23 US US05/615,951 patent/US4119637A/en not_active Expired - Lifetime
-
1976
- 1976-09-08 IL IL50436A patent/IL50436A/xx unknown
- 1976-09-09 ZA ZA765417A patent/ZA765417B/xx unknown
- 1976-09-15 PH PH18910A patent/PH13940A/en unknown
- 1976-09-17 SE SE7610362A patent/SE418397B/sv not_active IP Right Cessation
- 1976-09-17 CH CH1183076A patent/CH616659A5/fr not_active IP Right Cessation
- 1976-09-20 BR BR7606209A patent/BR7606209A/pt unknown
- 1976-09-21 MX MX764936U patent/MX3846E/es unknown
- 1976-09-21 GB GB39125/76A patent/GB1552686A/en not_active Expired
- 1976-09-21 GB GB234/79A patent/GB1552687A/en not_active Expired
- 1976-09-21 IE IE2085/76A patent/IE44843B1/en unknown
- 1976-09-21 FI FI762694A patent/FI67370C/fi not_active IP Right Cessation
- 1976-09-21 CA CA261,718A patent/CA1077497A/en not_active Expired
- 1976-09-21 BE BE170788A patent/BE846402A/xx not_active IP Right Cessation
- 1976-09-21 FR FR7628327A patent/FR2333792A1/fr active Granted
- 1976-09-22 DK DK426376A patent/DK160548C/da not_active IP Right Cessation
- 1976-09-22 DE DE19762642608 patent/DE2642608A1/de active Granted
- 1976-09-22 PT PT65624A patent/PT65624B/pt unknown
- 1976-09-22 ES ES451752A patent/ES451752A1/es not_active Expired
- 1976-09-22 NL NL7610526A patent/NL7610526A/xx not_active Application Discontinuation
- 1976-09-22 DE DE2661028A patent/DE2661028C2/de not_active Expired
- 1976-09-23 AU AU18048/76A patent/AU512445B2/en not_active Ceased
- 1976-09-23 AU AU18048/76A patent/AU1804876A/en not_active Ceased
- 1976-09-24 JP JP51114602A patent/JPS6059228B2/ja not_active Expired
-
1977
- 1977-02-04 FR FR7703256A patent/FR2329665A1/fr active Granted
- 1977-04-22 ES ES458181A patent/ES458181A1/es not_active Expired
-
1985
- 1985-06-26 JP JP14012285A patent/JPS6127977A/ja active Granted
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: A.H. ROBINS COMPANY, INCORPORATED |