FI66866C - Foerfarande foer framstaellning av antiproliferativa 2,4-diamino-6-(dialkoxibensyl)pyrido(2,3-d)pyrimidiner - Google Patents
Foerfarande foer framstaellning av antiproliferativa 2,4-diamino-6-(dialkoxibensyl)pyrido(2,3-d)pyrimidiner Download PDFInfo
- Publication number
- FI66866C FI66866C FI801912A FI801912A FI66866C FI 66866 C FI66866 C FI 66866C FI 801912 A FI801912 A FI 801912A FI 801912 A FI801912 A FI 801912A FI 66866 C FI66866 C FI 66866C
- Authority
- FI
- Finland
- Prior art keywords
- diamino
- acid
- formula
- dimethoxybenzyl
- compounds
- Prior art date
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- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068917 polyethylene glycols Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000006894 reductive elimination reaction Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7920705 | 1979-06-14 | ||
| GB7920703 | 1979-06-14 | ||
| GB7920705 | 1979-06-14 | ||
| GB7920703 | 1979-06-14 | ||
| GB7920704 | 1979-06-14 | ||
| GB7920706 | 1979-06-14 | ||
| GB7920706 | 1979-06-14 | ||
| GB7920704 | 1979-06-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI801912A7 FI801912A7 (fi) | 1980-12-15 |
| FI66866B FI66866B (fi) | 1984-08-31 |
| FI66866C true FI66866C (fi) | 1984-12-10 |
Family
ID=27449125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI801912A FI66866C (fi) | 1979-06-14 | 1980-06-13 | Foerfarande foer framstaellning av antiproliferativa 2,4-diamino-6-(dialkoxibensyl)pyrido(2,3-d)pyrimidiner |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0021292B1 (da) |
| AU (1) | AU532842B2 (da) |
| CA (1) | CA1132137A (da) |
| DE (1) | DE3062268D1 (da) |
| DK (1) | DK157451C (da) |
| FI (1) | FI66866C (da) |
| HU (1) | HU184787B (da) |
| IE (1) | IE49992B1 (da) |
| IL (1) | IL60307A (da) |
| IT (1) | IT1146940B (da) |
| MY (1) | MY8500059A (da) |
| NZ (1) | NZ194045A (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8702758D0 (en) * | 1987-02-06 | 1987-03-11 | Wellcome Found | Treatment of disease |
| EP0278686A1 (en) * | 1987-02-07 | 1988-08-17 | The Wellcome Foundation Limited | Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof |
| US4889859A (en) * | 1988-02-05 | 1989-12-26 | The Trustees Of Princeton University | Pyrido[2,3-d]pyrimidine derivatives |
| US5547954A (en) * | 1994-05-26 | 1996-08-20 | Fmc Corporation | 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides |
| KR20000070751A (ko) * | 1997-02-05 | 2000-11-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 세포 증식 억제제로서의 피리도[2,3-ｄ]피리미딘 및 4-아미노피리미딘 |
| US6498163B1 (en) | 1997-02-05 | 2002-12-24 | Warner-Lambert Company | Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
| EP1806348A3 (en) * | 1997-02-05 | 2008-01-02 | Warner-Lambert Company LLC | Pyrido [2, 3 -d] pyrimidines and 4-amino-primidines as inhibitors of cellular proliferation |
| EP1801112A1 (en) * | 1998-05-26 | 2007-06-27 | Warner-Lambert Company LLC | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| EE200000706A (et) * | 1998-05-26 | 2002-06-17 | Warner-Lambert Company | Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid |
| MXPA01012206A (es) * | 1999-05-24 | 2002-06-21 | Sankyo Co | Composiciones farmaceuticas que contienen anticuerpo anti-fas. |
| ATE314370T1 (de) | 2002-01-22 | 2006-01-15 | Warner Lambert Co | 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2937284A (en) * | 1958-05-01 | 1960-05-17 | Burroughs Wellcome Co | 2, 4-diamino-5, 6-dialkylpyrido (2, 3-d) pyrimidines and method |
| GB970583A (en) * | 1961-07-19 | 1964-09-23 | Wellcome Found | 2,4-diaminopyrido[2,3-d]pyrimidines |
| US3322765A (en) * | 1963-10-30 | 1967-05-30 | Burroughs Wellcome Co | 2, 4-diamino-6-benzylpyrido-(2, 3-d) pyrimidines and method |
-
1980
- 1980-06-13 IT IT48968/80A patent/IT1146940B/it active
- 1980-06-13 HU HU801494A patent/HU184787B/hu not_active IP Right Cessation
- 1980-06-13 FI FI801912A patent/FI66866C/fi not_active IP Right Cessation
- 1980-06-13 DK DK254780A patent/DK157451C/da not_active IP Right Cessation
- 1980-06-13 IL IL60307A patent/IL60307A/xx unknown
- 1980-06-13 CA CA354,009A patent/CA1132137A/en not_active Expired
- 1980-06-13 DE DE8080103325T patent/DE3062268D1/de not_active Expired
- 1980-06-13 NZ NZ194045A patent/NZ194045A/en unknown
- 1980-06-13 AU AU59275/80A patent/AU532842B2/en not_active Expired
- 1980-06-13 EP EP80103325A patent/EP0021292B1/en not_active Expired
- 1980-06-13 IE IE1220/80A patent/IE49992B1/en not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY59/85A patent/MY8500059A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY8500059A (en) | 1985-12-31 |
| DK254780A (da) | 1980-12-15 |
| IE49992B1 (en) | 1986-01-22 |
| IT1146940B (it) | 1986-11-19 |
| DK157451C (da) | 1990-05-21 |
| IL60307A0 (en) | 1980-09-16 |
| IL60307A (en) | 1984-02-29 |
| NZ194045A (en) | 1984-09-28 |
| AU532842B2 (en) | 1983-10-13 |
| FI66866B (fi) | 1984-08-31 |
| DE3062268D1 (en) | 1983-04-14 |
| EP0021292A1 (en) | 1981-01-07 |
| CA1132137A (en) | 1982-09-21 |
| IE801220L (en) | 1980-12-14 |
| AU5927580A (en) | 1980-12-18 |
| HU184787B (en) | 1984-10-29 |
| DK157451B (da) | 1990-01-08 |
| IT8048968A0 (it) | 1980-06-13 |
| FI801912A7 (fi) | 1980-12-15 |
| EP0021292B1 (en) | 1983-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: THE WELLCOME FOUNDATION LIMITED |