FI66380C - Foerfarande foer framstaellning av nya antireproduktiva 1,2,4-triazolo(5,1-a)isoindoler -isokinoliner och -bensazepiner - Google Patents
Foerfarande foer framstaellning av nya antireproduktiva 1,2,4-triazolo(5,1-a)isoindoler -isokinoliner och -bensazepiner Download PDFInfo
- Publication number
- FI66380C FI66380C FI793215A FI793215A FI66380C FI 66380 C FI66380 C FI 66380C FI 793215 A FI793215 A FI 793215A FI 793215 A FI793215 A FI 793215A FI 66380 C FI66380 C FI 66380C
- Authority
- FI
- Finland
- Prior art keywords
- compounds
- triazolo
- compound
- formula
- antireproductive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (2)
1. Förfarande för framställning av nya, antireproduktiva 1»2,4-triazolo |5 , l-a~| isoindoler, -isokinoliner och -bensazepiner med formeIn (I) « /”λ Il -Γ «V» (I) - A i vilken A betecknar -CHj-, -CHj-CHj-, -CH=CH- eller -(CH^-, kännetecknat dSrav, att en molar mängd av en förening med formeln N-NH- (II) I i -A i vilken A betecknar detsamma som ovan, eller av ett syra-additions-salt dirav, bringas i kontakt med atminstone en molar ekvivalent av en *örening med *orhein
1 ViyV eller av ett syra-additionssalt därav, i vilken Ρ? är . NH .NH S NH S ^ 4? -CH, -CONH,, -C , -C , -C eller -C 2 \ \ \ \ 0R3 nNH2 xNH2 sr3 i vilka R3 är en alkygrupp med 1-3 kolatomer, för en tid mellan ca 5-15 timmar, eventuellt i ett organiskt lösningsmedel, som är (C1_l4)-alkanol, (C1_4)-alkoxi-(C1 ^)-alkanol, etylengykol, propylen-
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7842415 | 1978-10-30 | ||
GB7842415 | 1978-10-30 | ||
US06/087,371 US4275066A (en) | 1978-10-30 | 1979-10-23 | Antireproductive tricyclic ortho-fused nitrogen containing compounds |
US8737179 | 1979-10-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI793215A FI793215A (fi) | 1980-05-01 |
FI66380B FI66380B (fi) | 1984-06-29 |
FI66380C true FI66380C (fi) | 1984-10-10 |
Family
ID=26269380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI793215A FI66380C (fi) | 1978-10-30 | 1979-10-16 | Foerfarande foer framstaellning av nya antireproduktiva 1,2,4-triazolo(5,1-a)isoindoler -isokinoliner och -bensazepiner |
Country Status (18)
Country | Link |
---|---|
US (1) | US4275066A (sv) |
JP (1) | JPS5562086A (sv) |
AT (2) | AT374803B (sv) |
AU (1) | AU532045B2 (sv) |
BE (1) | BE879729A (sv) |
CA (1) | CA1123827A (sv) |
CH (1) | CH650261A5 (sv) |
DE (1) | DE2943286A1 (sv) |
DK (1) | DK154298C (sv) |
FI (1) | FI66380C (sv) |
FR (1) | FR2440370A1 (sv) |
GB (1) | GB2039888B (sv) |
GR (1) | GR70248B (sv) |
HK (1) | HK24383A (sv) |
IE (1) | IE49625B1 (sv) |
LU (1) | LU81833A1 (sv) |
NL (1) | NL7907783A (sv) |
ZA (1) | ZA795743B (sv) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1211437A (en) * | 1981-08-12 | 1986-09-16 | Rene Borer | Benzazepines |
US5302589A (en) * | 1992-08-07 | 1994-04-12 | Glaxo, Inc. | Heterocyclic inhibitors of 5-α-testosterone reductase |
CN100432074C (zh) * | 2006-06-29 | 2008-11-12 | 浙江大学 | 2-芳基咪唑并[2,1-a]异喹啉的合成方法 |
JP5412809B2 (ja) * | 2008-11-21 | 2014-02-12 | コニカミノルタ株式会社 | イミダゾール化合物の製造方法 |
RU2657832C1 (ru) * | 2017-06-07 | 2018-06-15 | федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" | Антидиабетическое средство |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3758480A (en) * | 1968-07-10 | 1973-09-11 | Mallinckrodt Chemical Works | S-triazolo(5,1-a)isoquinolines and derivatives thereof |
US3775417A (en) * | 1971-08-05 | 1973-11-27 | Mallinckrodt Chemical Works | Selective hydrogenation of tri-and tetrazoloisoquinolines |
GB1477302A (en) * | 1973-05-25 | 1977-06-22 | Lepetit Spa | Triazolo-isoindole and triazolo-isoquinoline derivatives and their manufacture and uses |
RO66059A (ro) * | 1973-05-25 | 1981-05-30 | Gruppo Lepetit Spa,It | Procedeu de obtinere a unor derivati de triazolochinoline |
US4075341A (en) * | 1974-05-24 | 1978-02-21 | Gruppo Lepetit S.P.A. | 2-Substituted phenyl-5-triazols [5,1-a] isoquinoline compounds |
GB1484615A (en) * | 1974-11-23 | 1977-09-01 | Lepetit Spa | Tricyclic n-containing derivatives |
IT1054655B (it) * | 1975-08-27 | 1981-11-30 | Lepetit Spa | Derivati condensati del l isochinolina |
DE2707272C2 (de) * | 1977-02-19 | 1982-12-02 | Gruppo Lepetit S.p.A., 20158 Milano | 2-(p-Chlorphenyl)-s-triazolo [5,1-a] isochinolin |
US4093728A (en) * | 1977-08-18 | 1978-06-06 | E. R. Squibb & Sons, Inc. | Triazoloisoindoles |
-
1979
- 1979-10-13 GR GR60257A patent/GR70248B/el unknown
- 1979-10-16 FI FI793215A patent/FI66380C/fi not_active IP Right Cessation
- 1979-10-18 AU AU51908/79A patent/AU532045B2/en not_active Ceased
- 1979-10-23 NL NL7907783A patent/NL7907783A/nl not_active Application Discontinuation
- 1979-10-23 US US06/087,371 patent/US4275066A/en not_active Expired - Lifetime
- 1979-10-26 DK DK452779A patent/DK154298C/da not_active IP Right Cessation
- 1979-10-26 IE IE2067/79A patent/IE49625B1/en unknown
- 1979-10-26 ZA ZA00795743A patent/ZA795743B/xx unknown
- 1979-10-26 DE DE19792943286 patent/DE2943286A1/de active Granted
- 1979-10-29 CH CH9672/79A patent/CH650261A5/it not_active IP Right Cessation
- 1979-10-29 AT AT0697179A patent/AT374803B/de not_active IP Right Cessation
- 1979-10-29 GB GB7937388A patent/GB2039888B/en not_active Expired
- 1979-10-29 LU LU81833A patent/LU81833A1/fr unknown
- 1979-10-29 JP JP13971079A patent/JPS5562086A/ja active Granted
- 1979-10-30 BE BE0/197894A patent/BE879729A/fr not_active IP Right Cessation
- 1979-10-30 FR FR7926902A patent/FR2440370A1/fr active Granted
- 1979-10-30 CA CA338,698A patent/CA1123827A/en not_active Expired
-
1983
- 1983-06-20 AT AT0226083A patent/AT384427B/de not_active IP Right Cessation
- 1983-07-28 HK HK243/83A patent/HK24383A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI66380B (fi) | 1984-06-29 |
ZA795743B (en) | 1980-10-29 |
DK154298B (da) | 1988-10-31 |
AU5190879A (en) | 1980-05-08 |
JPS5562086A (en) | 1980-05-10 |
DE2943286C2 (sv) | 1990-05-23 |
CA1123827A (en) | 1982-05-18 |
HK24383A (en) | 1983-08-05 |
FR2440370A1 (fr) | 1980-05-30 |
GB2039888B (en) | 1982-11-03 |
US4275066A (en) | 1981-06-23 |
FI793215A (fi) | 1980-05-01 |
DE2943286A1 (de) | 1980-05-14 |
BE879729A (fr) | 1980-04-30 |
DK452779A (da) | 1980-05-01 |
CH650261A5 (it) | 1985-07-15 |
IE792067L (en) | 1980-04-30 |
NL7907783A (nl) | 1980-05-02 |
AT384427B (de) | 1987-11-10 |
AU532045B2 (en) | 1983-09-15 |
AT374803B (de) | 1984-06-12 |
FR2440370B1 (sv) | 1982-10-29 |
GR70248B (sv) | 1982-09-01 |
ATA226083A (de) | 1987-04-15 |
IE49625B1 (en) | 1985-11-13 |
JPS6354716B2 (sv) | 1988-10-28 |
GB2039888A (en) | 1980-08-20 |
ATA697179A (de) | 1983-10-15 |
DK154298C (da) | 1989-03-28 |
LU81833A1 (fr) | 1980-05-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4229453A (en) | Substituted 5,6-dimethylpyrrolo[2,3-d]pyrimidine compounds, their production and their medicinal use | |
FI88504B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-benzyl-1-(2h)-ftalazinonderivat | |
Chern et al. | Studies on quinazolines. 5. 2, 3-Dihydroimidazo [1, 2-c] quinazoline derivatives: a novel class of potent and selective. alpha. 1-adrenoceptor antagonists and antihypertensive agents | |
SK284071B6 (sk) | Spôsob prípravy dihalogénazolopyrimidínov | |
US4405635A (en) | 4-Aroylimidazol-2-ones and their use as pharmaceuticals | |
US4960773A (en) | Xanthine derivatives | |
FI66380C (fi) | Foerfarande foer framstaellning av nya antireproduktiva 1,2,4-triazolo(5,1-a)isoindoler -isokinoliner och -bensazepiner | |
EP0030351B1 (en) | Ergoline derivatives, their preparation and therapeutic composition containing them | |
CS197276B2 (en) | Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines | |
EP0157219A1 (en) | 3N-substituted 3,4-dihydropyrimidine derivatives, processes for preparing them and pharmaceutical compositions | |
FI57105B (fi) | Foerfarande foer framstaellning av nya s-triazolo(5,1-a)isoindoliner med befruktningsfoerhindrande verkan | |
EP0222474B1 (en) | Gamma-carbolines | |
SK14672001A3 (sk) | Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh | |
FI57104B (fi) | Foerfarande foer framstaellning av befruktningshindrande nya s-triatsolo(5,1-a)isokinolinderivat | |
US4313950A (en) | Antireproductive tricyclic ortho-fused nitrogen containing compounds | |
JPS634544B2 (sv) | ||
US4134894A (en) | Pyrrolo[1,2-a]indole compounds | |
CA1310638C (en) | Imidazo-benzodiazepines and their use in the treatment of memory or cerebral senescence disorders | |
CA1131220A (en) | Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1h-1-benzazepin-2-one, their preparation, and pharmaceutical formulations containing the said compounds | |
SE446097B (sv) | Tricykliska kvevehaltiga foreningar, forfarande for framstellning derav och farmaceutisk komposition derav | |
KR830001668B1 (ko) | 삼환식의 o-융합된 질소함유 화합물의 제조방법 | |
JP3657986B2 (ja) | イミダゾ〔1,5−a〕インドール−3−オンのイミダゾリルアルキル誘導体およびそれらの製造法 | |
NZ191960A (en) | Tricyclic or thofused nitrogen containing heterocycles | |
EP0001401A1 (en) | Thienobenzazepine derivatives, processes for their production and pharmaceutical compositions containing them | |
GB1572077A (en) | Pyrimidine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: GRUPPO LEPETIT S.P.A. |