FI65064C - Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter Download PDF

Info

Publication number
FI65064C
FI65064C FI792005A FI792005A FI65064C FI 65064 C FI65064 C FI 65064C FI 792005 A FI792005 A FI 792005A FI 792005 A FI792005 A FI 792005A FI 65064 C FI65064 C FI 65064C
Authority
FI
Finland
Prior art keywords
hydroxy
dimethyl
methyl
benzomorphane
mol
Prior art date
Application number
FI792005A
Other languages
English (en)
Finnish (fi)
Other versions
FI792005A (fi
FI65064B (fi
Inventor
Herbert Merz
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI792005A publication Critical patent/FI792005A/fi
Application granted granted Critical
Publication of FI65064B publication Critical patent/FI65064B/fi
Publication of FI65064C publication Critical patent/FI65064C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI792005A 1978-06-26 1979-06-25 Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter FI65064C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782828039 DE2828039A1 (de) 1978-06-26 1978-06-26 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
DE2828039 1978-06-26

Publications (3)

Publication Number Publication Date
FI792005A FI792005A (fi) 1979-12-27
FI65064B FI65064B (fi) 1983-11-30
FI65064C true FI65064C (fi) 1984-03-12

Family

ID=6042819

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792005A FI65064C (fi) 1978-06-26 1979-06-25 Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter

Country Status (19)

Country Link
US (1) US4293556A (fr)
EP (1) EP0006449B1 (fr)
JP (1) JPS5513278A (fr)
AT (1) ATE1947T1 (fr)
AU (1) AU518470B2 (fr)
CA (1) CA1107280A (fr)
DE (2) DE2828039A1 (fr)
DK (1) DK156719C (fr)
ES (1) ES481873A1 (fr)
FI (1) FI65064C (fr)
GR (1) GR69233B (fr)
IE (1) IE48430B1 (fr)
IL (1) IL57648A (fr)
MX (1) MX5680E (fr)
NO (1) NO149888C (fr)
NZ (1) NZ190816A (fr)
PH (1) PH15864A (fr)
PT (1) PT69823A (fr)
ZA (1) ZA793150B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
GB2144639B (en) * 1983-08-11 1986-10-15 Edward Carden Jetting tube for use in micro-laryngeal surgery
JPS61294094A (ja) * 1985-06-24 1986-12-24 東洋ベントナイト株式会社 シ−ルド堀進に於ける裏込補助工法
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
JPH05312414A (ja) * 1992-05-12 1993-11-22 Yukimatsu Fujimoto 集熱器二段の太陽熱温水器
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
JP5451611B2 (ja) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
JP5769970B2 (ja) 2007-11-16 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (fr) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11β-hydroxystéroïde déshydrogénase 1
EP2254872A2 (fr) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Inhibiteurs de 11beta-hydroxystéroïde deshydrogénase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5301563B2 (ja) 2008-05-01 2013-09-25 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2291370B1 (fr) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
TW200950780A (en) 2008-05-13 2009-12-16 Boehringer Ingelheim Int Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (fr) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
AR078887A1 (es) * 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417094A (en) * 1965-05-05 1968-12-17 Geigy Chem Corp Optically active 1,2,3,4,5,6-hexahydro-6-phenyl - 2,6 - methano - 3 - benzazocines an
NL132138C (fr) * 1966-05-20
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
BR6914879D0 (pt) * 1969-01-23 1973-02-08 Merck & Co Inc Processos quimicos
JPS55383B2 (fr) * 1971-09-13 1980-01-08
DE2233088A1 (de) * 1972-06-30 1974-01-17 Schering Ag Benzomorphanderivate
US4020164A (en) * 1972-06-30 1977-04-26 Schering Aktiengesellschaft Benzomorphan derivatives
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates

Also Published As

Publication number Publication date
MX5680E (es) 1983-12-08
AU4832779A (en) 1980-01-03
EP0006449B1 (fr) 1982-12-08
NZ190816A (en) 1980-11-28
US4293556A (en) 1981-10-06
EP0006449A1 (fr) 1980-01-09
DK156719B (da) 1989-09-25
JPS5513278A (en) 1980-01-30
AU518470B2 (en) 1981-10-01
CA1107280A (fr) 1981-08-18
DK266179A (da) 1979-12-27
JPH0159271B2 (fr) 1989-12-15
NO792119L (no) 1979-12-28
IE791189L (en) 1979-12-26
DE2964196D1 (en) 1983-01-13
ZA793150B (en) 1981-03-25
FI792005A (fi) 1979-12-27
NO149888B (no) 1984-04-02
IL57648A0 (en) 1979-10-31
ATE1947T1 (de) 1982-12-15
DE2828039A1 (de) 1980-01-10
FI65064B (fi) 1983-11-30
PT69823A (de) 1979-07-01
IL57648A (en) 1984-01-31
PH15864A (en) 1983-04-13
GR69233B (fr) 1982-05-10
IE48430B1 (en) 1985-01-23
DK156719C (da) 1990-02-19
ES481873A1 (es) 1980-02-16
NO149888C (no) 1984-07-11

Similar Documents

Publication Publication Date Title
FI65064C (fi) Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter
EP0796849B1 (fr) Nouveaux composes aminopyridiniques polycycliques inhibiteurs d'acetylcholinesterase, procede de preparation et utilisation
US3982005A (en) 2-Tetrahydrofurfuryl-5-(methyl or phenyl)-9β-methyl-2'-oxy-6,7-benzomorphans and salts thereof
NO141800B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzomorfaner
FI62079C (fi) Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter
US3714149A (en) Pyridobenzodiazepinones
EP0028717B1 (fr) Dérivés de 6,7-benzomorphane, procédés pour leur préparation, compositions pharmaceutiques contenant lesdits dérivés et leur utilisation comme médicaments
US3138603A (en) New benzomorphans (methanobenzazocines) and preparation thereof
Merz et al. Stereoisomeric 5, 9-dimethyl-2'-hydroxy-2-tetrahydrofurfuryl-6, 7-benzomorphans, strong analgesics with nonmorphinelike action profiles
US3914233A (en) 4-Hydroxy-N-substituted morphinan derivatives
KONDA et al. Amino Acids and Peptides. XXIII. An Asymmetric Synthesis of (R)-(-)-Laudanosine from L-3-(3, 4-Dihydroxyphenyl) alanine
YAMATO et al. Chemical structure and sweet taste of isocoumarin and related compounds. VII
US4058531A (en) Process for the preparation of 14-hydroxymorphinan derivatives
US2970144A (en) Esters of 9-alkyl-3-oxa and 3-thia-9-azabicyclo [3. 3. 1]-nonan-7-ol
PL141501B1 (en) Method of obtaining novel derivatives of quinoline and indene
Herz et al. Furano (3, 2-c) pyridines1
US3810899A (en) 2-hydroxy-n-substituted-morphinan derivatives
US3839338A (en) 1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO{8 g{9 QUINOLINES
US4139534A (en) Process for the preparation of 14-hydroxymorphinan derivatives
US4194044A (en) Process for preparing 3-phenoxy morphinans
US4247697A (en) 3-Phenoxy morphinans and their derivatives
EP0001585B1 (fr) Dérivés de pipérazino-pyrrolobenzodiazépine, leurs procédés de préparation et compositions pharmaceutiques les contenant
US3914234A (en) 2-Lower alkoxy-N-substituted-morphinan derivatives
Bosch et al. Benzomorphan related compounds. IV. The stevens rearrangement of a trimethoxybenzyl‐1, 2, 5, 6‐tetrahydropyridinium salt
KANAO et al. Spasmolytic Agents. I. Aminoalcohol Esters having a Phenethylamine-Like Moiety

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: C.H. BOEHRINGER SOHN