FI62289C - Foerfarande foer framstaellning av farmaceutiskt aktiva 2-deskarboxy-2-(tetrazol-5-yl)-11-desoxy-omega-pentanorprostaglandiner - Google Patents

Foerfarande foer framstaellning av farmaceutiskt aktiva 2-deskarboxy-2-(tetrazol-5-yl)-11-desoxy-omega-pentanorprostaglandiner Download PDF

Info

Publication number
FI62289C
FI62289C FI753474A FI753474A FI62289C FI 62289 C FI62289 C FI 62289C FI 753474 A FI753474 A FI 753474A FI 753474 A FI753474 A FI 753474A FI 62289 C FI62289 C FI 62289C
Authority
FI
Finland
Prior art keywords
phenyl
tetrazol
trans
hydroxy
oxo
Prior art date
Application number
FI753474A
Other languages
English (en)
Finnish (fi)
Other versions
FI62289B (fi
FI753474A (ja
Inventor
Michael Ross Johnson
Thomas Ken Schaaf
James Frederick Eggler
Jasjit Singh Bindra
Hans-Juergen Ernst Hess
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI753474A publication Critical patent/FI753474A/fi
Priority to FI803527A priority Critical patent/FI803527L/fi
Application granted granted Critical
Publication of FI62289B publication Critical patent/FI62289B/fi
Publication of FI62289C publication Critical patent/FI62289C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI753474A 1974-12-11 1975-12-10 Foerfarande foer framstaellning av farmaceutiskt aktiva 2-deskarboxy-2-(tetrazol-5-yl)-11-desoxy-omega-pentanorprostaglandiner FI62289C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI803527A FI803527L (fi) 1974-12-11 1980-11-11 Som mellanprodukt anvaendbart substituerat pentan foer framstaellning av 2-deskarboxy-2-(tetrazol-5-yl)-11-desoxy-w -pentanorprostaglandiner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53167574 1974-12-11
US05/531,675 US3932389A (en) 1974-12-11 1974-12-11 2-Descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-.omega.-pentanorprostaglandins

Publications (3)

Publication Number Publication Date
FI753474A FI753474A (ja) 1976-06-12
FI62289B FI62289B (fi) 1982-08-31
FI62289C true FI62289C (fi) 1982-12-10

Family

ID=24118587

Family Applications (1)

Application Number Title Priority Date Filing Date
FI753474A FI62289C (fi) 1974-12-11 1975-12-10 Foerfarande foer framstaellning av farmaceutiskt aktiva 2-deskarboxy-2-(tetrazol-5-yl)-11-desoxy-omega-pentanorprostaglandiner

Country Status (24)

Country Link
US (1) US3932389A (ja)
JP (2) JPS5186465A (ja)
AR (1) AR222623A1 (ja)
BE (1) BE836563A (ja)
CA (1) CA1059122A (ja)
CH (2) CH614434A5 (ja)
CS (3) CS191995B2 (ja)
DD (2) DD129644A5 (ja)
DK (1) DK560075A (ja)
ES (1) ES443422A1 (ja)
FI (1) FI62289C (ja)
FR (1) FR2293927A1 (ja)
GB (2) GB1515414A (ja)
GR (1) GR58521B (ja)
HU (1) HU175278B (ja)
IE (1) IE42937B1 (ja)
IL (1) IL48637A (ja)
LU (1) LU73996A1 (ja)
NL (1) NL163509C (ja)
NO (1) NO145381C (ja)
NZ (1) NZ179503A (ja)
SE (2) SE415759B (ja)
YU (1) YU313775A (ja)
ZA (1) ZA757754B (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102894A (en) * 1975-11-19 1978-07-25 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
US4035360A (en) * 1974-12-11 1977-07-12 Pfizer Inc. Magnesium salts of 2-descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-omega-pentanoprostaglandins
US3984400A (en) * 1975-10-21 1976-10-05 Pfizer Inc. 11-Desoxy-16-aryl-ω-tetranorprostaglandins
JPS5295670A (en) * 1976-02-04 1977-08-11 Pfizer 22decarboxyy225 tetrazoll55yl**11deoxyy omegaapentanolprostaglandine
US4342868A (en) * 1977-06-13 1982-08-03 Pfizer Inc. 2-Descarboxy-2-(tetrazol-5-yl)-16,16-dimethyl-17-(2-furyl)-ω-trisnorprostaglandin E2
US4404372A (en) * 1977-06-13 1983-09-13 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandin derivatives
US4097601A (en) * 1977-08-26 1978-06-27 Pfizer Inc. Bone deposition by 2-descarboxy-2-(tetrazol-5-yl)-11-dexosy-16-aryl prostaglandins
JPS54119465A (en) * 1979-02-02 1979-09-17 Pfizer Intermediate for manufacturing 22decarboxyy 22*tetrasoll55yl**111deoxyyomegaapentanol prostaglandin
JPS54119464A (en) * 1979-02-02 1979-09-17 Pfizer Intermediate for manufacturing 22decarboxyy 22*tetrasoll55yl**111deoxyyomegaapentanol prostaglandin
US4336393A (en) * 1979-04-02 1982-06-22 The Upjohn Company 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG1 compounds
US4336371A (en) * 1979-04-02 1982-06-22 The Upjohn Company 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG2 compounds
US4336372A (en) * 1979-04-02 1982-06-22 The Upjohn Company 2-Decarboxy-2-tetrazolyl-PG2 compounds
US4336392A (en) * 1979-04-02 1982-06-22 The Upjohn Company 2-Decarboxy-2-tetrazolyl-PG1 compounds
JPS5991116U (ja) * 1982-12-09 1984-06-20 名倉　啓介 バツクル
HN1996000101A (es) 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
AU7349298A (en) 1997-06-23 1999-01-04 Pfizer Inc. Prostaglandin agonists
US20010056060A1 (en) * 2000-02-07 2001-12-27 Cameron Kimberly O. Treatment of osteoporsis with EP2/EP4 receptor selective agonists
US20020161026A1 (en) * 2000-11-07 2002-10-31 Paralkar Vishwas M. Combination therapies for the stimulation of bone growth
CA2458230A1 (en) * 2001-08-23 2003-03-06 Sucampo Ag Method and composition for treatment of ocular hypertension and glaucoma
EP1490055A1 (en) * 2002-03-18 2004-12-29 Pfizer Products Inc. Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
US20030220377A1 (en) * 2002-05-08 2003-11-27 Richard Chesworth Indole compounds and their use as estrogen agonists/antagonists
US20040002524A1 (en) * 2002-06-24 2004-01-01 Richard Chesworth Benzimidazole compounds and their use as estrogen agonists/antagonists
US20050203086A1 (en) * 2004-03-04 2005-09-15 Pfizer Inc. Methods of treatment using an EP2 selective receptor agonist
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
BRPI0619492A2 (pt) * 2005-12-07 2011-10-04 Univ Ramot derivados quìmicos de jasmonato, composições famacêuticas e métodos de uso dos mesmos
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
AU2019223014B2 (en) 2018-02-21 2024-10-17 AI Therapeutics, Inc. Combination therapy with apilimod and glutamatergic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788209A (fr) * 1971-09-01 1973-02-28 Pfizer Derives tetrazoyliques des prostaglandines naturelles

Also Published As

Publication number Publication date
IE42937L (en) 1976-06-11
ES443422A1 (es) 1977-04-16
YU313775A (en) 1982-06-30
GB1515414A (en) 1978-06-21
NL7514447A (nl) 1976-06-15
FI62289B (fi) 1982-08-31
ZA757754B (en) 1976-11-24
GB1515415A (en) 1978-06-21
DD129644A5 (de) 1978-02-01
NO145381C (no) 1982-03-10
US3932389A (en) 1976-01-13
JPS5186465A (en) 1976-07-29
CA1059122A (en) 1979-07-24
DK560075A (da) 1976-06-12
SE7907780L (sv) 1979-09-19
NO754174L (ja) 1976-06-14
FI753474A (ja) 1976-06-12
FR2293927A1 (fr) 1976-07-09
CH612188A5 (ja) 1979-07-13
AU8736375A (en) 1977-06-02
GR58521B (en) 1977-10-29
CS191996B2 (en) 1979-07-31
NZ179503A (en) 1978-07-10
HU175278B (hu) 1980-06-28
CS191995B2 (en) 1979-07-31
DD129648A5 (de) 1978-02-01
IE42937B1 (en) 1980-11-19
CS191960B2 (en) 1979-07-31
AR222623A1 (es) 1981-06-15
IL48637A (en) 1979-12-30
NO145381B (no) 1981-11-30
LU73996A1 (ja) 1976-11-11
SE415759B (sv) 1980-10-27
SE7513708L (sv) 1976-06-14
IL48637A0 (en) 1976-02-29
JPS52116471A (en) 1977-09-29
NL163509C (nl) 1980-09-15
FR2293927B1 (ja) 1979-02-23
JPS568035B2 (ja) 1981-02-20
BE836563A (fr) 1976-06-11
CH614434A5 (ja) 1979-11-30
NL163509B (nl) 1980-04-15
JPS541711B2 (ja) 1979-01-27

Similar Documents

Publication Publication Date Title
FI62289C (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva 2-deskarboxy-2-(tetrazol-5-yl)-11-desoxy-omega-pentanorprostaglandiner
US4116989A (en) 16-Phenoxy prostaglandin F1α analogs
US4029681A (en) 13,14-Didehydro-PG analogs
FI58912B (fi) Analogifoerfarande foer framstaellning av nya terapeutiskt aktiva foereningar tillhoerande prostaglandinserierna e och f
US3883513A (en) Tetrazoyl derivatives of naturally occurring prostaglandins
IE43916B1 (en) 16-phenoxy-and 16-substituted phenoxy-prostatrienoic acid derivatives and processes for the production thereof
FI60389C (fi) Nya 16-aryloxisubstituerade omega-tetranorprostaglandiner vilka aer anvaendbara saosom befruktning foerhindrande medel
US3931206A (en) Prostanoic acid derivatives
US4013695A (en) 4,4,5,5-Tetradehydro-PGE1 analogs
US4169895A (en) Antisecretory 16,16-dimethyl-17-oxaprostaglandins
US4138575A (en) 11-Deoxy-16-phenoxy-PGF compounds
US3931279A (en) 5-Oxa prostaglandin F2.sub.α analogs
US4154949A (en) 11-Desoxy-15-substituted-ω-pentanor prostaglandins
NO143741B (no) Analogifremgangsmaate for fremstilling av fysiologisk aktive prostaglandinforbindelser av e- og f-serien
US4000305A (en) 15-, 16- AND 17-Indolyl or indolinyl nor prostanoic acid derivatives
JPS5846510B2 (ja) １３，１４−デヒドロ−１１−デオキシ−プロスタグランジン及びその製造法
NO754195L (ja)
FI58116C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva parabifenylestrar av prostaglandinserierna e och f
US4029693A (en) 2A,2B-Dihomo-11-deoxy-17(substituted phenyl)-18,19,20-trinor-PGE2 compounds and their corresponding esters
US4074044A (en) Cyanoprostaglandins
US4035360A (en) Magnesium salts of 2-descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-omega-pentanoprostaglandins
CA1085832A (en) Prostaglandin analogs
US3993686A (en) Phenyl substituted prostaglandins-C-type analogs
JPS581117B2 (ja) １１−デオキシ−ω−ペンタノルプロスタグランジン類
CA1119591A (en) Prostane derivatives

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: PFIZER INC.