FI61183C - Foerfarande foer framstaellning av terapeutiskt anvaendbara n-fenylpyrroler - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara n-fenylpyrroler Download PDF

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Publication number
FI61183C
FI61183C FI580/74A FI58074A FI61183C FI 61183 C FI61183 C FI 61183C FI 580/74 A FI580/74 A FI 580/74A FI 58074 A FI58074 A FI 58074A FI 61183 C FI61183 C FI 61183C
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Finland
Prior art keywords
mol
hours
moles
carboxy
phenyl
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FI580/74A
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English (en)
Finnish (fi)
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FI61183B (fi
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Richard C Allen
V Brian Anderson
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Hoechst Ag
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Publication date
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Publication of FI61183B publication Critical patent/FI61183B/fi
Publication of FI61183C publication Critical patent/FI61183C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)

Claims (2)

1. Menetelmä terapeuttisesti käytettävien N-fenyylipyrrolien valmistamiseksi, joilla on kaava: O--R3 X V—' y-H I^jL (Rujossa n R on vety, alkyyli, jossa on 1-6 hiiliatomia, tienyyli, fenyyli, tai fenyyli, joka on substituoitu halogeenilla, trifluorimetyylillä, alkyylillä, jossa on 1-6 hiiliatomia, alkoksilla, jossa on 1-6 hiiliatomia, nitrolla, syaanilla, hydroksyylillä, aminolla tai fenyylillä; R^ on karboksyyli, alkoksikarbonyyli, jossa on 2-7 hiiliatomia, karbamoyyli, N-alkyylikarbamoyyli, jossa on 2-7 hiiliatomia, Ν,Ν-dialkyylikarbamoyyli, jossa on 3-7 hiiliatomia, hydroksikarbamoyyli tai dialkyylifosfinyylialkoksikarbo-nyyli, jossa on 4-10 hiiliatomia; R2 on vety, hydroksyyli, merkapto, halogeeni, trifluorimetyyli, alkoksi, jossa on 1-6 hiiliatomia, alkanoyylioksi, jossa on 1-6 hiiliatomia, amino, alkanoyyli-araino, jossa on 1-6 hiiliatomia, dialkyylitiokarbamoyylioksi, jossa on 3-7 hiili-atomia, tai dialkyylikarbamoyylitio, jossa on 3-7 hiiliatomia, R^ on vety, alkanoyyli, jossa on 1-6 hiiliatomia, tai fenyyli; X on alkyleeni, jossa on 3-5 hiiliatomia, alkyleeni, jossa on 3-5 hiiliatomia ja joka on substituoitu alkyylillä tai alkoksilla, joissa on 1-6 hiiliatomia, di-vinyleeni, divinyleeni, joka on substituoitu alkyylillä, jossa on 1-6 hiiliatomia, 11· 71 I Y- Yj -YY ^ tai joissa kaavoissa D on vety, alkoksi, jossa on 1-6 hiiliatomia tai halogeeni; ja n on 1 tai 2, tunnettu siitä, että yhdiste, jolla on kaava: 61183 60 II ?3 Z' \-CH-C-R ' II saatetaan reagoimaan aniliinin kanssa, jolla on kaava: Λ 4-. (RJ 2 n joissa kaavoissa X,R,R^,R2,R.3 ja n tarkoittavat samaa kuin edellä. 61 61183
1. Förfarande för framställning av terapeutiskt användbara N-fenylpyrroler med formeln: ---*3 ^-K 1 1 —R1 aa, R är väte, alkyl med 1-6 kolatomer, tienyl, fenyl eller fenyl substituerad med halogen, trifluormetyl, alkyl med 1-6 kolatomer, alkoxi med 1-6 kolatomer, nitro, cyan, hydroxyl, amino eller fenyl, R^ är karboxyl, alkoxikarbonyl med 2-7 kolatomer, karbamoyl, N-alkylkarbamoyl med 2-7 kolatomer, Ν,Ν-dialkylkarbamoyl med 3-7 kolatomer, hydroxikarbamoyl eller dialkylfosfinylalkoxikarbonyl med 4-10 kolatomer, R2 är väte, hydroxyl, merkapto, halogen, trifluormetyl, alkoxi med 1-6 kolatomer, alkanoyloxi med 1-6 kolatomer, amino, alkanoylamino med 1-6 kolatomer, dialkyltiokarbamoyloxi med 3-7 kolatomer eller dialkylkarbamoyltio med 3~7 kolatomer, är väte, alkanoyl med 1-6 kolatomer eller fenyl·, X är alkylen med 3-5 kolatomer, alkylen med 3-5 kolatomer substituerad med alkyl eller alkoxi med 1-6 kolatomer, divinylen, divinylen substituerad med alkyl med 1-6 kolatomer, I D~f I D L'' ,'-·'" ' eller där D är väte, alkoxi med 1-6 kolatomer, eller halogen, och n är 1 eller 2, kännetecknat därav, att man omsätter en förening med formeln:
FI580/74A 1973-03-01 1974-02-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara n-fenylpyrroler FI61183C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33691973 1973-03-01
US336919A US3878225A (en) 1973-03-01 1973-03-01 Condensed pyrroles bearing an N-phenyl substituent

Publications (2)

Publication Number Publication Date
FI61183B FI61183B (fi) 1982-02-26
FI61183C true FI61183C (fi) 1982-06-10

Family

ID=23318274

Family Applications (1)

Application Number Title Priority Date Filing Date
FI580/74A FI61183C (fi) 1973-03-01 1974-02-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara n-fenylpyrroler

Country Status (20)

Country Link
US (1) US3878225A (sv)
JP (1) JPS6139304B2 (sv)
AT (1) AT332389B (sv)
BE (1) BE811785A (sv)
CA (1) CA1025455A (sv)
CH (1) CH611605A5 (sv)
CS (1) CS191225B2 (sv)
DE (1) DE2407671C2 (sv)
ES (2) ES423562A1 (sv)
FI (1) FI61183C (sv)
FR (1) FR2219790B1 (sv)
GB (1) GB1457601A (sv)
HU (1) HU170834B (sv)
IE (1) IE38943B1 (sv)
IL (1) IL44279A (sv)
NL (1) NL177828C (sv)
NO (1) NO142346C (sv)
SE (1) SE397523B (sv)
SU (1) SU610488A3 (sv)
ZA (1) ZA741333B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056624A (en) * 1976-05-14 1977-11-01 American Hoechst Corporation Method of treating dermal inflammation
US5145965A (en) * 1987-09-24 1992-09-08 Hoechst-Roussel Pharmaceuticals Incorporated 2,6-methanopyrrolo-3-benzazocines
US4929622A (en) * 1987-09-24 1990-05-29 Hoechst-Roussel Pharmaceuticals, Inc. 2,6-Methanopyrrolo-3-benzazocines
US4814501A (en) * 1987-12-28 1989-03-21 Merck & Co., Inc. Process for preparing N,N-dimethyl 2-(methylthio) benzamides and analogs
US9216966B2 (en) 2004-10-04 2015-12-22 John Manfredi Compounds for Alzheimer's disease
US7678823B2 (en) 2004-10-04 2010-03-16 Myriad Pharmaceticals, Inc. Compounds for alzheimer's disease
EP1809601B1 (en) * 2004-10-04 2014-09-10 Manfredi, John Compounds for alzheimer's disease
JP2009532501A (ja) * 2006-04-04 2009-09-10 ミリアド ジェネティクス， インコーポレイテッド 疾患および障害のための化合物
CA2694216A1 (en) * 2007-07-24 2009-01-29 Astellas Pharma Inc. Benzimidazole derivative
WO2009127686A1 (en) * 2008-04-16 2009-10-22 Karo Bio Ab Novel estrogen receptor ligands
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70880A (sv) *
US3687971A (en) * 1970-06-22 1972-08-29 Merck & Co Inc 4-(pyrrolyl)-salicylic acid derivatives
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
FR2219790B1 (sv) 1978-09-22
ZA741333B (en) 1975-02-26
BE811785A (fr) 1974-09-02
FI61183B (fi) 1982-02-26
FR2219790A1 (sv) 1974-09-27
CS191225B2 (en) 1979-06-29
IE38943B1 (en) 1978-07-05
NL177828B (nl) 1985-07-01
US3878225A (en) 1975-04-15
NO142346C (no) 1980-08-06
JPS49134671A (sv) 1974-12-25
DE2407671C2 (de) 1983-12-01
ES437259A1 (es) 1977-01-01
CA1025455A (en) 1978-01-31
ATA165474A (de) 1976-01-15
JPS6139304B2 (sv) 1986-09-03
DE2407671A1 (de) 1974-09-12
NO142346B (no) 1980-04-28
GB1457601A (en) 1976-12-08
AU6618874A (en) 1975-09-04
HU170834B (hu) 1977-09-28
IL44279A0 (en) 1974-05-16
CH611605A5 (sv) 1979-06-15
NL177828C (nl) 1985-12-02
NO740694L (no) 1974-09-03
SU610488A3 (ru) 1978-06-05
ES423562A1 (es) 1976-06-01
SE397523B (sv) 1977-11-07
AT332389B (de) 1976-09-27
NL7402465A (sv) 1974-09-03
IL44279A (en) 1977-10-31
IE38943L (en) 1974-09-01

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