FI59794C - Foerfarande foer framstaellning av heterocykliska benzamidfoereningar med biologisk aktivitet - Google Patents
Foerfarande foer framstaellning av heterocykliska benzamidfoereningar med biologisk aktivitet Download PDFInfo
- Publication number
- FI59794C FI59794C FI199873A FI199873A FI59794C FI 59794 C FI59794 C FI 59794C FI 199873 A FI199873 A FI 199873A FI 199873 A FI199873 A FI 199873A FI 59794 C FI59794 C FI 59794C
- Authority
- FI
- Finland
- Prior art keywords
- compound
- sulfamoyl
- heterocyclic
- reaction
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. Förfarande för framställning av en biologiskt aktiv hetero-cyklisk benzamidförening eller ett syraadditionssalt därav med den allmänna formeIn .. 0 - x-^ - NH - CH2__Jv^ (I) — OCH3 i2H5 väri X representerar en sulfamoyl-, N-lägre alkylsulfamoyl- eller N,N-di(lägre alkyl)sulfamoylgrupp, kännetecknat av en heterocyklisk förening med formeln —C - NH - CHp-v J (Ha) I ΐ oRl c2h5 där representerar väte eller metyl, alkyleras i sd fall, att representerar väte, tili motsvarande 2-metoxiförening, varefter 2-metoxiföreningen klorsulfo-neras tili motsvarande 5-klorsulfonylförening, 5~klorsulfonylgruppen 1 den sd erhallna föreningen omsättes genom ammonolys med ammoniak eller aminolys med en primär amin eller sekundär amin tili motsvarande 5-sulfamoyl-, N-lägre alkylsulfamoyl- eller N,N-di(lägre alkyl)-sulfamoylförening, och slutligen omsättes, da sa önskas, den sa erhallna produkten tili ett syraadditionssalt.
2. Förfarande enligt patentkravet 1,kännetecknat av att 5~klorsulfonylföreningen omsättes direkt, utan isolering, tili motsvarande 5-sulfamoyl-, 5-N-lägre alkylsulfamoyl- eller
5-N,N-di(lägre alkyl)sulfamoylförening.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att den heterocykliska benzamidfÖreningen enligt formeln Ila, som användes som utgangsmaterial i klorsulfoneringsreaktionen, är i form av ett syraadditionssalt.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26580372A | 1972-06-23 | 1972-06-23 | |
US26580372 | 1972-06-23 | ||
GB5624072 | 1972-12-06 | ||
GB5624072 | 1972-12-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI59794B FI59794B (fi) | 1981-06-30 |
FI59794C true FI59794C (fi) | 1981-10-12 |
Family
ID=26267599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI199873A FI59794C (fi) | 1972-06-23 | 1973-06-20 | Foerfarande foer framstaellning av heterocykliska benzamidfoereningar med biologisk aktivitet |
Country Status (11)
Country | Link |
---|---|
AR (1) | AR211685A1 (sv) |
CA (1) | CA982589A (sv) |
CH (1) | CH584688A5 (sv) |
DE (1) | DE2331959A1 (sv) |
DK (1) | DK136359B (sv) |
ES (1) | ES416231A1 (sv) |
FI (1) | FI59794C (sv) |
FR (1) | FR2189062A1 (sv) |
NL (1) | NL7308729A (sv) |
NO (1) | NO142301B (sv) |
SE (1) | SE389107B (sv) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2445829A2 (fr) * | 1978-02-27 | 1980-08-01 | Synthelabo | Methoxy-2 benzamides et leur application en therapeutique |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
ES403003A1 (es) * | 1972-05-19 | 1973-06-16 | Lepori Renault | Nuevo procedimiento para la preparacion de la 2-metoxi 5- sulfamoil benzoil (n etil) 2-pirrolidinometilamina. |
-
1973
- 1973-06-18 CH CH898773A patent/CH584688A5/xx not_active IP Right Cessation
- 1973-06-19 SE SE7308591A patent/SE389107B/sv unknown
- 1973-06-20 FI FI199873A patent/FI59794C/fi active
- 1973-06-20 FR FR7322534A patent/FR2189062A1/fr active Granted
- 1973-06-21 DK DK343973A patent/DK136359B/da unknown
- 1973-06-22 CA CA174,723A patent/CA982589A/en not_active Expired
- 1973-06-22 NO NO259273A patent/NO142301B/no unknown
- 1973-06-22 AR AR24866373A patent/AR211685A1/es active
- 1973-06-22 NL NL7308729A patent/NL7308729A/xx not_active Application Discontinuation
- 1973-06-22 DE DE19732331959 patent/DE2331959A1/de active Pending
-
1975
- 1975-09-18 ES ES416231A patent/ES416231A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NO142301B (no) | 1980-04-21 |
FR2189062B1 (sv) | 1976-09-03 |
DE2331959A1 (de) | 1974-01-10 |
FI59794B (fi) | 1981-06-30 |
FR2189062A1 (en) | 1974-01-25 |
NL7308729A (sv) | 1973-12-27 |
SE389107B (sv) | 1976-10-25 |
CH584688A5 (sv) | 1977-02-15 |
CA982589A (en) | 1976-01-27 |
ES416231A1 (es) | 1976-05-01 |
DK136359B (da) | 1977-10-03 |
AR211685A1 (es) | 1978-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE44641B1 (en) | 1,1-cycloalkyldiacetic acid imide derivatives and their use for preparing 1-aminomethyl-1-cycloalkylacetic acids | |
US3852338A (en) | N-substituted phenylalanine derivatives | |
US4297282A (en) | Resolution of mercaptopropionic acids | |
SU718009A3 (ru) | Способ получени 1-нитро-9-алкиламиноалкиламинакридинов или их солей | |
FI59794C (fi) | Foerfarande foer framstaellning av heterocykliska benzamidfoereningar med biologisk aktivitet | |
PT1607090E (pt) | Azimadolina para o tratamento da síndrome do cólon irritável | |
USRE29882E (en) | Synthesis of oxindoles from anilines and intermediates therein | |
US3972894A (en) | Synthesis of oxindoles from anilines and β-thio carboxylic esters or amides | |
US3655692A (en) | 3-amino-tetrahydrothiophene-3-carboxylic acids | |
ES2327816T3 (es) | Procedimiento para la preparacion de esteres de acido amico. | |
FI63750C (fi) | Foerfarande foer framstaellning av 2-oxo-pyrrolidin-n-alkylamider | |
JPH0641463B2 (ja) | チオテトロン酸の製造方法 | |
FI59793C (fi) | Mellanprodukt foer framstaellning av en heterocyklisk benzamid med farmakologisk aktivitet och foerfarande foer framstaellning av mellanprodukten | |
Pan et al. | Diastereospecific synthesis of trans-2, 3-diaryl-1-aminocyclopropanecarboxylic acids | |
Confalone et al. | A total synthesis of biotin based on derivatives of 2, 5-dihydrothiophene | |
US6284901B1 (en) | Dinitrile intermediates for the synthesis of omapatrilat and methods for producing same | |
JPS6055514B2 (ja) | イソ−イミドまたはイソ−イミド及びイミドの混合物の製造方法 | |
US6300503B1 (en) | Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same | |
US2741614A (en) | N-isobutylnormorpfflne compounds | |
Coutts et al. | The Synthesis of Some Analogs of the Hallucinogen 1-(2, 5-Dimethoxy-4-methyl-phenyl)-2-aminopropane (DOM). III. Some Derivatives of 3-phenylalanine | |
NO153368B (no) | Fremgangsmaate til fremstilling av 10-okso-10,11-dihydro-5h-dibenz(b,f)-asepin-5-karboksamid | |
CA1099719A (en) | Process for the preparation of n-(1-benzylpiperid-4- yl)-benzamides | |
Bojarska‐Dahlig | On the synthesis of derivatives of N‐(4‐pyridonyl)‐oxyacetic acid | |
Okada et al. | Aromatic nucleophilic substitution. X. Confirmation of the anionic. SIGMA. complex in the base-catalyzed smiles rearrangement of 2-(acetylamino) ethyl 2, 4-dinitrophenyl ether in dimethyl sulfoxide. | |
US3519622A (en) | Phenothiazine derivatives |