FI59676C - Foerfarande foer teknisk framstaellning av foerbeskiktade objektglas - Google Patents
Foerfarande foer teknisk framstaellning av foerbeskiktade objektglas Download PDFInfo
- Publication number
- FI59676C FI59676C FI760910A FI760910A FI59676C FI 59676 C FI59676 C FI 59676C FI 760910 A FI760910 A FI 760910A FI 760910 A FI760910 A FI 760910A FI 59676 C FI59676 C FI 59676C
- Authority
- FI
- Finland
- Prior art keywords
- slides
- dye
- staining
- purple
- nozzle
- Prior art date
Links
- 239000000975 dye Substances 0.000 description 26
- 239000000243 solution Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 15
- 239000007921 spray Substances 0.000 description 15
- 238000010186 staining Methods 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 238000005507 spraying Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 210000001995 reticulocyte Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000003350 kerosene Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 235000011449 Rosa Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- UEJQQMLXZQUJHF-UHFFFAOYSA-L [K+].[I+].[I-].[I-] Chemical compound [K+].[I+].[I-].[I-] UEJQQMLXZQUJHF-UHFFFAOYSA-L 0.000 description 1
- 239000012932 acetate dye Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- FAJDWNKDRFAWLS-UHFFFAOYSA-N benzyl-[9-(diethylamino)benzo[a]phenoxazin-5-ylidene]azanium;chloride Chemical compound [Cl-].O1C2=CC(N(CC)CC)=CC=C2N=C(C2=CC=CC=C22)C1=CC2=[NH+]CC1=CC=CC=C1 FAJDWNKDRFAWLS-UHFFFAOYSA-N 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 150000001721 carbon Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229960001235 gentian violet Drugs 0.000 description 1
- 210000004276 hyalin Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- VHGXRGXCDVQIKS-KRWDZBQOSA-N methyl (2s)-3-(4-methylphenyl)sulfonyloxy-2-(phenylmethoxycarbonylamino)propanoate Chemical compound C([C@@H](C(=O)OC)NC(=O)OCC=1C=CC=CC=1)OS(=O)(=O)C1=CC=C(C)C=C1 VHGXRGXCDVQIKS-KRWDZBQOSA-N 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2515869A DE2515869C3 (de) | 1975-04-11 | 1975-04-11 | Verfahren und Vorrichtung zur Herstellung von vorbeschichteten Objektträgern |
| DE2515869 | 1975-04-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI760910A FI760910A (es) | 1976-10-12 |
| FI59676B FI59676B (fi) | 1981-05-29 |
| FI59676C true FI59676C (fi) | 1981-09-10 |
Family
ID=5943617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI760910A FI59676C (fi) | 1975-04-11 | 1976-04-05 | Foerfarande foer teknisk framstaellning av foerbeskiktade objektglas |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4103041A (es) |
| JP (1) | JPS51135920A (es) |
| AR (1) | AR206748A1 (es) |
| AT (1) | AT342889B (es) |
| AU (1) | AU501167B2 (es) |
| BE (1) | BE840453A (es) |
| CA (1) | CA1069389A (es) |
| CH (1) | CH598608A5 (es) |
| CS (1) | CS222662B2 (es) |
| DD (1) | DD123627A5 (es) |
| DE (1) | DE2515869C3 (es) |
| DK (1) | DK148476A (es) |
| ES (1) | ES446834A1 (es) |
| FI (1) | FI59676C (es) |
| FR (1) | FR2307281A1 (es) |
| GB (1) | GB1480575A (es) |
| HU (1) | HU176480B (es) |
| IE (1) | IE42551B1 (es) |
| IT (1) | IT1059618B (es) |
| NL (1) | NL7603627A (es) |
| SE (1) | SE420354B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190472A (en) * | 1977-09-28 | 1980-02-26 | Alex Slonicki | Automated system for the application of coverglasses on histological and cytological slides |
| DE2826363C2 (de) * | 1978-06-16 | 1984-08-16 | Merck Patent Gmbh, 6100 Darmstadt | Deckfolie zur Verwendung in mikroskopischen Färbeverfahren und Verfahren zu ihrer Herstellung |
| US4248821A (en) * | 1979-07-25 | 1981-02-03 | Dellen Adrian F Van | Method and device for embedding a specimen for microscopic examination |
| US4523826A (en) * | 1980-12-15 | 1985-06-18 | University Of Pittsburgh | Autoradiography apparatus including a slide rack |
| WO1992019952A1 (en) * | 1991-05-07 | 1992-11-12 | Wescor, Inc. | Improved staining method for histology and cytology specimens |
| US5439649A (en) * | 1993-09-29 | 1995-08-08 | Biogenex Laboratories | Automated staining apparatus |
| US5817032A (en) * | 1996-05-14 | 1998-10-06 | Biopath Automation Llc. | Means and method for harvesting and handling tissue samples for biopsy analysis |
| CA2321100A1 (en) * | 1998-02-19 | 1999-08-26 | Edvotek | Articles of manufacture and methods for staining biomolecules |
| US6572824B1 (en) * | 1998-09-18 | 2003-06-03 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
| US6562299B1 (en) * | 1998-09-18 | 2003-05-13 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
| US20070166834A1 (en) * | 1998-10-05 | 2007-07-19 | Biopath Automation, L.L.C. | Apparatus and method for harvesting and handling tissue samples for biopsy analysis |
| US7179424B2 (en) * | 2002-09-26 | 2007-02-20 | Biopath Automation, L.L.C. | Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor |
| DK2322938T3 (da) * | 2002-09-26 | 2013-04-08 | Biopath Automation Llc | Apparat og fremgangsmåde til automatisk håndtering og indlejring af vævsprøver |
| EP1545775B1 (en) * | 2002-09-26 | 2010-06-16 | BioPath Automation, L.L.C. | Cassette and embedding assembly, staging devices, and methods for handling tissue samples |
| US20070116612A1 (en) * | 2005-11-02 | 2007-05-24 | Biopath Automation, L.L.C. | Prefix tissue cassette |
| US20080102526A1 (en) | 2006-10-30 | 2008-05-01 | Sysmex Corporation | Reagent, reagent kit and analyzing method |
| WO2008073387A1 (en) * | 2006-12-12 | 2008-06-19 | Biopath Automation, L.L.C. | Biopsy support with sectionable resilient cellular material |
| WO2009105758A1 (en) * | 2008-02-22 | 2009-08-27 | Materials And Technologies Corporation | Single-sided high throughput wet etching and wet processing apparatus and method |
| US20100167334A1 (en) * | 2008-12-30 | 2010-07-01 | Biopath Automation, L.L.C. | Systems and methods for processing tissue samples for histopathology |
| US8329120B2 (en) * | 2009-01-22 | 2012-12-11 | Biopath Automation, L.L.C. | Microtome sectionable biopsy support for orienting tissue samples |
| CN103299173B (zh) | 2010-11-10 | 2017-05-03 | 罗氏血液诊断股份有限公司 | 制备用于检查的生物标本的自动化系统及方法 |
| RU2619784C2 (ru) * | 2011-09-13 | 2017-05-18 | Конинклейке Филипс Н.В. | Система и набор для получения цитологических образцов для исследования |
| JP6444371B2 (ja) | 2013-04-05 | 2018-12-26 | ロッシュ ダイアグノスティクス ヘマトロジー インコーポレイテッド | 試験のために生物学的試料を調製する自動化されたシステムおよび方法 |
| US20220317434A1 (en) * | 2021-04-03 | 2022-10-06 | Keith Louis De Santo | Micro-organism identification using light microscopes, conveyor belts, static electricity, artificial intelligence and machine learning algorithms |
| CN113405878B (zh) * | 2021-08-04 | 2023-09-29 | 深圳明志医学检验实验室 | 一种适用于医疗病理检测用血液临时装片制作的辅助设备 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3004875A (en) * | 1957-11-22 | 1961-10-17 | Pittsburgh Plate Glass Co | Coating glass sheets |
| US3056696A (en) * | 1958-06-04 | 1962-10-02 | Libbey Owens Ford Glass Co | Ultrathin films |
| US3107058A (en) * | 1960-01-07 | 1963-10-15 | Vllbiss Company De | Atomizer for preparing microscopic slides |
| US3352280A (en) * | 1964-05-01 | 1967-11-14 | Coulter Electronics | Centrifugal apparatus for slide staining |
| US3495926A (en) * | 1966-11-02 | 1970-02-17 | John F Naz | Method and apparatus for staining microslides |
| US3667896A (en) * | 1968-10-21 | 1972-06-06 | Miles Lab | Applying film of stain to tissue mounted on a moving slide |
| US3906120A (en) * | 1970-10-30 | 1975-09-16 | Gen Electric | Method for preparing slides for blood evaluation |
| US3796594A (en) * | 1970-10-30 | 1974-03-12 | Gen Electric | Stain coated slides for differentially staining blood |
| US3837795A (en) * | 1971-11-05 | 1974-09-24 | Biomatics Instr Corp | Method and apparatus for staining slides |
| US3900641A (en) * | 1972-01-21 | 1975-08-19 | Lancaster Products Company | Method of forming decorator panels |
| US3834874A (en) * | 1972-10-18 | 1974-09-10 | Gen Electric | Detection of malarial parasites in blood |
| US3853092A (en) * | 1973-10-25 | 1974-12-10 | Corning Glass Works | Apparatus for nutating and staining a microscope slide |
| FR2263502B1 (es) * | 1974-03-06 | 1976-12-10 | Ass Ctre Transfusion San | |
| US3932681A (en) * | 1974-03-11 | 1976-01-13 | Corning Glass Works | Ceramic masking method |
| US4089989A (en) * | 1975-04-04 | 1978-05-16 | White Ronald D | Method for preparing microscope slides by rotating during coating |
-
1975
- 1975-04-11 DE DE2515869A patent/DE2515869C3/de not_active Expired
-
1976
- 1976-01-01 AR AR262782A patent/AR206748A1/es active
- 1976-02-27 SE SE7602727A patent/SE420354B/xx unknown
- 1976-03-31 US US05/672,574 patent/US4103041A/en not_active Expired - Lifetime
- 1976-03-31 DK DK148476A patent/DK148476A/da not_active IP Right Cessation
- 1976-04-05 FI FI760910A patent/FI59676C/fi not_active IP Right Cessation
- 1976-04-05 HU HU76BO1608A patent/HU176480B/hu unknown
- 1976-04-05 AU AU12676/76A patent/AU501167B2/en not_active Expired
- 1976-04-06 GB GB13852/76A patent/GB1480575A/en not_active Expired
- 1976-04-06 DD DD192222A patent/DD123627A5/xx unknown
- 1976-04-07 CS CS762301A patent/CS222662B2/cs unknown
- 1976-04-07 IT IT22061/76A patent/IT1059618B/it active
- 1976-04-07 BE BE165899A patent/BE840453A/xx not_active IP Right Cessation
- 1976-04-07 CA CA249,727A patent/CA1069389A/en not_active Expired
- 1976-04-07 CH CH439276A patent/CH598608A5/xx not_active IP Right Cessation
- 1976-04-07 NL NL7603627A patent/NL7603627A/xx not_active Application Discontinuation
- 1976-04-09 ES ES446834A patent/ES446834A1/es not_active Expired
- 1976-04-09 FR FR7610488A patent/FR2307281A1/fr active Granted
- 1976-04-09 AT AT261976A patent/AT342889B/de not_active IP Right Cessation
- 1976-04-09 IE IE751/76A patent/IE42551B1/en unknown
- 1976-04-12 JP JP51041172A patent/JPS51135920A/ja active Pending
-
1978
- 1978-04-24 US US05/899,666 patent/US4224277A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL7603627A (nl) | 1976-10-13 |
| CA1069389A (en) | 1980-01-08 |
| FI59676B (fi) | 1981-05-29 |
| FR2307281B1 (es) | 1981-09-11 |
| DD123627A5 (es) | 1977-01-05 |
| GB1480575A (en) | 1977-07-20 |
| DE2515869B2 (de) | 1979-03-15 |
| SE7602727L (sv) | 1976-10-12 |
| SE420354B (sv) | 1981-09-28 |
| AT342889B (de) | 1978-04-25 |
| US4103041A (en) | 1978-07-25 |
| IE42551L (en) | 1976-10-11 |
| CS222662B2 (en) | 1983-07-29 |
| DE2515869C3 (de) | 1979-11-08 |
| US4224277A (en) | 1980-09-23 |
| FR2307281A1 (fr) | 1976-11-05 |
| DK148476A (da) | 1976-10-12 |
| DE2515869A1 (de) | 1976-10-21 |
| AU1267676A (en) | 1977-10-13 |
| ATA261976A (de) | 1977-08-15 |
| JPS51135920A (en) | 1976-11-25 |
| IE42551B1 (en) | 1980-08-27 |
| FI760910A (es) | 1976-10-12 |
| HU176480B (en) | 1981-03-28 |
| IT1059618B (it) | 1982-06-21 |
| ES446834A1 (es) | 1977-06-01 |
| AU501167B2 (en) | 1979-06-14 |
| CH598608A5 (es) | 1978-05-12 |
| BE840453A (fr) | 1976-10-07 |
| AR206748A1 (es) | 1976-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: BOEHRINGER MANNHEIM GMBH |