FI58329C - Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat - Google Patents
Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat Download PDFInfo
- Publication number
- FI58329C FI58329C FI753097A FI753097A FI58329C FI 58329 C FI58329 C FI 58329C FI 753097 A FI753097 A FI 753097A FI 753097 A FI753097 A FI 753097A FI 58329 C FI58329 C FI 58329C
- Authority
- FI
- Finland
- Prior art keywords
- hydroxy
- dihydrocarbostyril
- formula
- propoxy
- grams
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
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- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960001008 heparin sodium Drugs 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000030564 negative regulation of blood pressure Effects 0.000 description 1
- 230000000802 nitrating effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- BHRZNVHARXXAHW-UHFFFAOYSA-N sec-butylamine Chemical compound CCC(C)N BHRZNVHARXXAHW-UHFFFAOYSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12938774 | 1974-11-08 | ||
| JP49129387A JPS5156462A (en) | 1974-11-08 | 1974-11-08 | 55 * 33 arukiruamino 22 hidorokishi * purohokishi 88 hidorokishi 3*44 jihidorokarubosuchiriruno seizoho |
| JP49129386A JPS5156461A (en) | 1974-11-08 | 1974-11-08 | *33 arukiruamino 22 hidorokishi * purohokishi 3*44 jihidorokarubosuchirirujudotaino seizoho |
| JP12938674 | 1974-11-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI753097A7 FI753097A7 (en, 2012) | 1976-05-09 |
| FI58329B FI58329B (fi) | 1980-09-30 |
| FI58329C true FI58329C (fi) | 1981-01-12 |
Family
ID=26464802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI753097A FI58329C (fi) | 1974-11-08 | 1975-11-05 | Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4072683A (en, 2012) |
| AR (1) | AR215578A1 (en, 2012) |
| AT (1) | AT349020B (en, 2012) |
| CH (2) | CH618430A5 (en, 2012) |
| DE (1) | DE2549889C2 (en, 2012) |
| DK (1) | DK144697C (en, 2012) |
| ES (1) | ES442455A1 (en, 2012) |
| FI (1) | FI58329C (en, 2012) |
| FR (2) | FR2290207A1 (en, 2012) |
| GB (2) | GB1505900A (en, 2012) |
| NL (1) | NL181107C (en, 2012) |
| NO (1) | NO145238C (en, 2012) |
| SE (1) | SE428015B (en, 2012) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210753A (en) * | 1976-03-17 | 1980-07-01 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds |
| CH619453A5 (en, 2012) * | 1976-03-17 | 1980-09-30 | Otsuka Pharma Co Ltd | |
| JPS609713B2 (ja) * | 1976-10-08 | 1985-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| US4314943A (en) * | 1977-07-13 | 1982-02-09 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| US4495352A (en) * | 1979-02-13 | 1985-01-22 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
| DE2909035A1 (de) * | 1979-03-08 | 1980-09-18 | Hoechst Ag | 8-oxo-5,6,7,8-tetrahydro-2-chinolon und verfahren zu dessen herstellung |
| US4322425A (en) * | 1980-03-14 | 1982-03-30 | Otsuka Pharmaceutical Co., Ltd. | Compositions for treating glaucoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1058822A (en) * | 1963-07-30 | 1967-02-15 | Ici Ltd | 3-amino-2-hydroxypropoxy heterocyclic derivatives |
| NL6400510A (en, 2012) * | 1964-01-23 | 1965-07-26 | ||
| JPS421182Y1 (en, 2012) * | 1964-01-24 | 1967-01-24 | ||
| US3910924A (en) * | 1972-04-13 | 1975-10-07 | Otsuka Pharma Co Ltd | 3,4-Dihydrocarbostyril derivatives and a process for preparing the same |
| JPS517672B2 (en, 2012) * | 1972-04-13 | 1976-03-10 | ||
| AR207554A1 (es) * | 1972-12-02 | 1976-10-15 | Otsuka Pharma Co Ltd | Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2) |
| JPS5239035B2 (en, 2012) * | 1972-12-14 | 1977-10-03 |
-
1975
- 1975-11-05 FI FI753097A patent/FI58329C/fi not_active IP Right Cessation
- 1975-11-06 DE DE2549889A patent/DE2549889C2/de not_active Expired
- 1975-11-07 GB GB36139/77A patent/GB1505900A/en not_active Expired
- 1975-11-07 FR FR7534056A patent/FR2290207A1/fr active Granted
- 1975-11-07 SE SE7512498A patent/SE428015B/xx not_active IP Right Cessation
- 1975-11-07 DK DK502575A patent/DK144697C/da not_active IP Right Cessation
- 1975-11-07 ES ES442455A patent/ES442455A1/es not_active Expired
- 1975-11-07 AR AR261112A patent/AR215578A1/es active
- 1975-11-07 GB GB46233/75A patent/GB1505899A/en not_active Expired
- 1975-11-07 NL NLAANVRAGE7513098,A patent/NL181107C/xx not_active IP Right Cessation
- 1975-11-07 NO NO753739A patent/NO145238C/no unknown
- 1975-11-07 CH CH1445975A patent/CH618430A5/de not_active IP Right Cessation
- 1975-11-07 AT AT850975A patent/AT349020B/de not_active IP Right Cessation
- 1975-11-10 US US05/630,631 patent/US4072683A/en not_active Expired - Lifetime
-
1976
- 1976-05-26 FR FR7615953A patent/FR2303801A1/fr active Granted
-
1980
- 1980-07-23 CH CH563880A patent/CH624673A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO145238C (no) | 1982-02-10 |
| CH624673A5 (en, 2012) | 1981-08-14 |
| DK144697C (da) | 1982-11-08 |
| GB1505900A (en) | 1978-03-30 |
| CH618430A5 (en, 2012) | 1980-07-31 |
| FR2290207A1 (fr) | 1976-06-04 |
| FI58329B (fi) | 1980-09-30 |
| AR215578A1 (es) | 1979-10-31 |
| SE7512498L (sv) | 1976-05-10 |
| FR2303801A1 (fr) | 1976-10-08 |
| FR2290207B1 (en, 2012) | 1978-09-22 |
| DE2549889C2 (de) | 1985-06-05 |
| DE2549889A1 (de) | 1976-05-20 |
| DK502575A (da) | 1976-05-09 |
| ATA850975A (de) | 1978-08-15 |
| DK144697B (da) | 1982-05-17 |
| US4072683A (en) | 1978-02-07 |
| GB1505899A (en) | 1978-03-30 |
| FR2303801B1 (en, 2012) | 1978-05-19 |
| NO753739L (en, 2012) | 1976-05-11 |
| NO145238B (no) | 1981-11-02 |
| ES442455A1 (es) | 1977-07-16 |
| AU8647675A (en) | 1977-05-19 |
| NL181107B (nl) | 1987-01-16 |
| NL7513098A (nl) | 1976-05-11 |
| NL181107C (nl) | 1987-06-16 |
| FI753097A7 (en, 2012) | 1976-05-09 |
| SE428015B (sv) | 1983-05-30 |
| AT349020B (de) | 1979-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: OTSUKA PHARMACEUTICAL CO. LTD. |