FI46259C - Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi. - Google Patents
Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi.Info
- Publication number
- FI46259C FI46259C FI693710A FI371069A FI46259C FI 46259 C FI46259 C FI 46259C FI 693710 A FI693710 A FI 693710A FI 371069 A FI371069 A FI 371069A FI 46259 C FI46259 C FI 46259C
- Authority
- FI
- Finland
- Prior art keywords
- benzodiazepin
- alkyloxy
- pyrrolo
- hexahydro
- ethylidene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8368 | 1968-12-30 | ||
JP44050780A JPS4843755B1 (fi) | 1969-06-26 | 1969-06-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI46259B FI46259B (fi) | 1972-10-31 |
FI46259C true FI46259C (fi) | 1973-02-12 |
Family
ID=26332992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI693710A FI46259C (fi) | 1968-12-30 | 1969-12-22 | Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi. |
Country Status (6)
Country | Link |
---|---|
ES (1) | ES375013A1 (fi) |
FI (1) | FI46259C (fi) |
GB (1) | GB1299198A (fi) |
IE (1) | IE33906B1 (fi) |
IL (1) | IL33558A (fi) |
RO (1) | RO55813A (fi) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464467A (en) * | 1982-07-26 | 1984-08-07 | Bristol-Myers Company | Antitumor antibiotics produced by new streptomyces |
GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
PT1413582E (pt) | 1998-08-27 | 2006-07-31 | Spirogen Ltd | Pirrolobenzodiazepinas dimericas |
GB9818732D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
US6909006B1 (en) | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
SI1720881T1 (sl) | 2004-03-01 | 2013-04-30 | Spirogen Sarl | 11-hidroksi-5H-pirolo(2,1-c)(1,4)benzodiazepin-5onski derivati kot ključni intermediati za pipravo C2 substituiranih pirolobenzodiazepinov |
GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
JP5166861B2 (ja) | 2004-03-09 | 2013-03-21 | スピロゲン リミティッド | ピロロベンゾジアゼピン |
GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
AU2011239522B2 (en) | 2010-04-15 | 2014-10-23 | Medimmune Limited | Targeted pyrrolobenzodiazapine conjugates |
AU2011239525B2 (en) | 2010-04-15 | 2015-04-09 | Medimmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
GB201006340D0 (en) | 2010-04-15 | 2010-06-02 | Spirogen Ltd | Synthesis method and intermediates |
CA2849039C (en) | 2011-09-20 | 2018-09-18 | Spirogen Sarl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
US9388187B2 (en) | 2011-10-14 | 2016-07-12 | Medimmune Limited | Pyrrolobenzodiazepines |
EA029046B1 (ru) | 2011-10-14 | 2018-02-28 | Медимьюн Лимитед | Пирролобензодиазепины и промежуточные соединения для их получения, способы их синтеза |
BR112014008888A2 (pt) | 2011-10-14 | 2017-04-18 | Seattle Genetics Inc | pirrolobenzodiazepinas |
EA036202B1 (ru) | 2011-10-14 | 2020-10-14 | Сиэтл Дженетикс, Инк. | Пирролбензодиазепины и конъюгаты направленного действия |
EP3388435B1 (en) | 2011-10-14 | 2023-05-03 | Seagen Inc. | Pyrrolobenzodiazepines and targeted conjugates |
EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
CA3060520C (en) | 2012-10-12 | 2022-05-17 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
NZ707486A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
NZ707534A (en) | 2012-10-12 | 2018-08-31 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
AU2013328673B2 (en) | 2012-10-12 | 2017-07-13 | Medimmune Limited | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
DK2906251T3 (da) | 2012-10-12 | 2017-11-20 | Adc Therapeutics Sa | Pyrrolobenzodiazepin-anti-CD22-antistofkonjugater |
PL2766048T3 (pl) | 2012-10-12 | 2015-05-29 | Medimmune Ltd | Pirolobenzodiazepiny i ich koniugaty |
MX364328B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
KR20170101895A (ko) | 2014-11-25 | 2017-09-06 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 접합체 |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
AU2018217926B2 (en) | 2017-02-08 | 2019-10-03 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
EP3612537B1 (en) | 2017-04-18 | 2022-07-13 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
US20200129637A1 (en) | 2017-04-20 | 2020-04-30 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
KR102442736B1 (ko) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | 항-cd19 adc의 투여를 위한 투약량 체제 |
JP7220203B2 (ja) | 2017-08-18 | 2023-02-09 | メドイミューン・リミテッド | ピロロベンゾジアゼピン複合体 |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
-
1969
- 1969-12-17 IL IL33558A patent/IL33558A/xx unknown
- 1969-12-22 FI FI693710A patent/FI46259C/fi active
- 1969-12-24 GB GB62863/69A patent/GB1299198A/en not_active Expired
- 1969-12-29 ES ES375013A patent/ES375013A1/es not_active Expired
- 1969-12-30 RO RO62025A patent/RO55813A/ro unknown
- 1969-12-30 IE IE1726/69A patent/IE33906B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI46259B (fi) | 1972-10-31 |
IL33558A (en) | 1973-10-25 |
ES375013A1 (es) | 1972-03-01 |
GB1299198A (en) | 1972-12-06 |
RO55813A (fi) | 1974-02-01 |
IE33906B1 (en) | 1974-12-11 |
IL33558A0 (en) | 1970-04-20 |
IE33906L (en) | 1970-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI46259C (fi) | Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi. | |
FI51347C (fi) | Menetelmä 1-substituoitujen-3- ja -4-aroyylipiperidiinien valmistamise ksi. | |
FI52574C (fi) | Menetelmä farmakologisesti arvokkaiden substituoitujen N-allyyli-2-fen yyliamino-imidatsoliinien-(2) valmistamiseksi. | |
DK132174B (da) | Analogifremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimider. | |
FI49503C (fi) | Analogiamenetelmä 1,2,3,4-tetrahydro-4-fenyyli-isokinoliinijohdannaist en valmistamiseksi. | |
DK123715B (da) | Fremgangsmåde til fremstilling af 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider. | |
FI48588C (fi) | Analogiamenetelmä terapeuttisesti vaikuttavien 3,4-dihydroisokinoliini johdannaisten valmistamiseksi. | |
DK140842B (da) | Fremgangsmåde til fremstilling af 8,9-didebydro-10alfa-alkoxy-ergolener. | |
RO71305A (ro) | Procedeu pentru prepararea d-halo-6-metil-2,8-ciano-(carboxamido)-ergoline | |
DK127812B (da) | Analogifremgangsmåde til fremstilling af 3,5-dibrom-zearalan. | |
DK127778B (da) | Fremgangsmåde til fremstilling af 3',4'-dideoxy-kenamycin B. | |
FI44625C (fi) | Menetelmä uusien terapeuttisesti arvokkaiden d-treo-1-fenyyli-2-amino-1,3-propaanidiolijohdannaisten valmistamiseksi | |
FI50710C (fi) | Menetelmä 1,4-bentsodiatsepiinien valmistamiseksi. | |
BE763173A (fr) | Procede de preparation de 6-alcoxy-5,6-dihydro-4h-pyrannes | |
RO67383A (ro) | Procedeu pentru prepararea unor 2,4-diamino-5-benzilpirimidine | |
FI46723C (fi) | Menetelmä 1,18-dimetyyli-5alfa-H-androst-1-eenijohdannaisten valmistam iseksi. | |
FI52225C (fi) | Menetelmä terapeuttisesti käytettävien 15alfa,16alfa-metyleeni-4-estre eni-17beta-olien valmistamiseksi. | |
FI47181C (fi) | Menetelmä tulehdusta estävien 2-kloori-6alfa,9alfa,11beta-trihalogeeni -16alfa-metyyli-pregnadieenin valmistamiseksi. | |
AR214033A1 (es) | Procedimiento para preparar 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocinas | |
FI45756C (fi) | Menetelmä kard-20(22)enolidien 3beta-tridesoksipyranosidien valmistami seksi. | |
DK121440B (da) | Analogifremgangsmåde til fremstilling af 2,4-bis-morpholino- eller-thiomorpholino-5-carbalkoxy-pyrimidiner. | |
DK129041B (da) | Analogifremgangsmåde til fremstilling af 6,21-dihalogen-3,16α,17α-trihydroxy-pregna-4,6-dien-20-oner. | |
BG15557A3 (bg) | Метод за получаване на n-ацил-1,2-дикарбонил-фенил- хидразони | |
FI48928C (fi) | Menetelmä (-)-norskopolamiinin valmistamiseksi. | |
FI47351C (fi) | Menetelmä 7alfa-metyyli-1alfa,2alfa-metyleeni-androstenolonien valmist amiseksi. |