FI46259C - Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi. - Google Patents

Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi.

Info

Publication number
FI46259C
FI46259C FI693710A FI371069A FI46259C FI 46259 C FI46259 C FI 46259C FI 693710 A FI693710 A FI 693710A FI 371069 A FI371069 A FI 371069A FI 46259 C FI46259 C FI 46259C
Authority
FI
Finland
Prior art keywords
benzodiazepin
alkyloxy
pyrrolo
hexahydro
ethylidene
Prior art date
Application number
FI693710A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI46259B (cg-RX-API-DMAC7.html
Inventor
Arima
Tamura
Sakai
Kohsaka
Kariyone
Yazawa
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of FI46259B publication Critical patent/FI46259B/fi
Publication of FI46259C publication Critical patent/FI46259C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI693710A 1968-12-30 1969-12-22 Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi. FI46259C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8368 1968-12-30
JP44050780A JPS4843755B1 (cg-RX-API-DMAC7.html) 1969-06-26 1969-06-26

Publications (2)

Publication Number Publication Date
FI46259B FI46259B (cg-RX-API-DMAC7.html) 1972-10-31
FI46259C true FI46259C (fi) 1973-02-12

Family

ID=26332992

Family Applications (1)

Application Number Title Priority Date Filing Date
FI693710A FI46259C (fi) 1968-12-30 1969-12-22 Menetelmä uusien terapeuttisesti arvokkaiden 11-alkyylioksi-1,2,3,10,1 1,11a-heksahydro-2-etyylideeni-7-metoksi-8-hydroksi-5H-pyrrolo/2,1-c/ /1,4/bentsodiatsepin-5-onien valmistamiseksi.

Country Status (6)

Country Link
ES (1) ES375013A1 (cg-RX-API-DMAC7.html)
FI (1) FI46259C (cg-RX-API-DMAC7.html)
GB (1) GB1299198A (cg-RX-API-DMAC7.html)
IE (1) IE33906B1 (cg-RX-API-DMAC7.html)
IL (1) IL33558A (cg-RX-API-DMAC7.html)
RO (1) RO55813A (cg-RX-API-DMAC7.html)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
ES2260570T3 (es) * 1998-08-27 2006-11-01 Spirogen Limited Pirrolobenziodiazepinas dimericas.
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
ES2398975T3 (es) 2004-03-01 2013-03-25 Spirogen Sàrl Derivados de 11-hidroxi-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2
EP1723152B1 (en) 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
MX368648B (es) 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
CN103068405A (zh) 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
US9399641B2 (en) 2011-09-20 2016-07-26 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
JP6166728B2 (ja) 2011-10-14 2017-07-19 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピンの製造に有用な合成方法及び中間体
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
AU2012322934B2 (en) 2011-10-14 2016-09-08 Medimmune Limited Pyrrolobenzodiazepines
CA2850264C (en) 2011-10-14 2019-11-05 Medimmune Limited Pyrrolobenzodiazepines
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
EP2906249B1 (en) 2012-10-12 2018-06-27 MedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
DK2839860T3 (da) 2012-10-12 2019-06-17 Medimmune Ltd Pyrrolobenzodiazepiner og konjugater deraf
PT2906248T (pt) 2012-10-12 2019-03-04 Medimmune Ltd Pirrolobenzodiazepinas e conjugados das mesmas
PT2906253T (pt) 2012-10-12 2018-11-05 Medimmune Ltd Conjugados de anticorpo anti-psma de pirrolobenzodiazepina
BR112015008238A2 (pt) 2012-10-12 2017-11-28 Adc Therapeutics Sarl conjugados de pirrolbenzodiazepina-anticorpo anti-cd22
DK2906298T3 (en) 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EP2906297B1 (en) 2012-10-12 2017-12-06 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
KR101995620B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
RS61795B1 (sr) 2017-02-08 2021-06-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin antitela
SMT202200490T1 (it) 2017-04-18 2023-01-13 Medimmune Ltd Coniugati di pirrolobenzodiazepina
WO2018193102A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (ko) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 항-cd19 adc의 투여를 위한 투약량 체제
SI3668874T1 (sl) 2017-08-18 2022-04-29 Medimmune Limited Pirolobenzodiazepinski konjugati
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN113631560B (zh) 2019-03-15 2025-02-18 麦迪穆有限责任公司 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物

Also Published As

Publication number Publication date
ES375013A1 (es) 1972-03-01
IL33558A (en) 1973-10-25
IL33558A0 (en) 1970-04-20
IE33906L (en) 1970-06-30
GB1299198A (en) 1972-12-06
RO55813A (cg-RX-API-DMAC7.html) 1974-02-01
FI46259B (cg-RX-API-DMAC7.html) 1972-10-31
IE33906B1 (en) 1974-12-11

Similar Documents

Publication Publication Date Title
FI51347C (fi) Menetelmä 1-substituoitujen-3- ja -4-aroyylipiperidiinien valmistamise ksi.
FI52574C (fi) Menetelmä farmakologisesti arvokkaiden substituoitujen N-allyyli-2-fen yyliamino-imidatsoliinien-(2) valmistamiseksi.
DK132174B (da) Analogifremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimider.
FI49503C (fi) Analogiamenetelmä 1,2,3,4-tetrahydro-4-fenyyli-isokinoliinijohdannaist en valmistamiseksi.
FI48588C (fi) Analogiamenetelmä terapeuttisesti vaikuttavien 3,4-dihydroisokinoliini johdannaisten valmistamiseksi.
DK123715B (da) Fremgangsmåde til fremstilling af 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider.
BG17560A3 (bg) Метод за получаане на 4,20, 22- буфатриеноли- драмнозид- етери
DK140842B (da) Fremgangsmåde til fremstilling af 8,9-didebydro-10alfa-alkoxy-ergolener.
RO71305A (ro) Procedeu pentru prepararea d-halo-6-metil-2,8-ciano-(carboxamido)-ergoline
BG22815A3 (bg) Метод за получаване на 2,6-диамино-дихидропиридини
DK127812B (da) Analogifremgangsmåde til fremstilling af 3,5-dibrom-zearalan.
DK127778B (da) Fremgangsmåde til fremstilling af 3',4'-dideoxy-kenamycin B.
DK127421B (da) Fremgangsmåde til fremstilling af cardenolid-3[2',3'-didesoxyglycosider].
BG19178A3 (bg) Метод за получаване на 8-субституирани-5н-пироло-(2,1-с) 1,4 бензодиазепин-5-они
FI44625C (fi) Menetelmä uusien terapeuttisesti arvokkaiden d-treo-1-fenyyli-2-amino-1,3-propaanidiolijohdannaisten valmistamiseksi
FI50710C (fi) Menetelmä 1,4-bentsodiatsepiinien valmistamiseksi.
AR214033A1 (es) Procedimiento para preparar 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocinas
RO67383A (ro) Procedeu pentru prepararea unor 2,4-diamino-5-benzilpirimidine
FI46723C (fi) Menetelmä 1,18-dimetyyli-5alfa-H-androst-1-eenijohdannaisten valmistam iseksi.
FI52225C (fi) Menetelmä terapeuttisesti käytettävien 15alfa,16alfa-metyleeni-4-estre eni-17beta-olien valmistamiseksi.
FI47181C (fi) Menetelmä tulehdusta estävien 2-kloori-6alfa,9alfa,11beta-trihalogeeni -16alfa-metyyli-pregnadieenin valmistamiseksi.
DK121440B (da) Analogifremgangsmåde til fremstilling af 2,4-bis-morpholino- eller-thiomorpholino-5-carbalkoxy-pyrimidiner.
DK118129B (da) Fremgangsmåde til fremstilling af card-20(22)-enolid-3β-tridesoxypyranosider.
DK129041B (da) Analogifremgangsmåde til fremstilling af 6,21-dihalogen-3,16α,17α-trihydroxy-pregna-4,6-dien-20-oner.
BG15557A3 (bg) Метод за получаване на n-ацил-1,2-дикарбонил-фенил- хидразони