FI120348B - Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi Download PDF

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Publication number
FI120348B
FI120348B FI924503A FI924503A FI120348B FI 120348 B FI120348 B FI 120348B FI 924503 A FI924503 A FI 924503A FI 924503 A FI924503 A FI 924503A FI 120348 B FI120348 B FI 120348B
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FI
Finland
Prior art keywords
thrombin
amino acid
atoms
pro
glu
Prior art date
Application number
FI924503A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924503A (fi
FI924503A0 (fi
Inventor
John M Maraganore
Jo-Ann M Jablonski
Paul R Bourdon
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of FI924503A publication Critical patent/FI924503A/fi
Publication of FI924503A0 publication Critical patent/FI924503A0/fi
Application granted granted Critical
Publication of FI120348B publication Critical patent/FI120348B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1016Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manipulator (AREA)
  • Pyrane Compounds (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
FI924503A 1991-02-08 1992-10-06 Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi FI120348B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65292991 1991-02-08
US07/652,929 US5240913A (en) 1989-08-18 1991-02-08 Inhibitors of thrombin
US9200836 1992-02-03
PCT/US1992/000836 WO1992013952A1 (en) 1991-02-08 1992-02-03 Improved inhibitors of thrombin

Publications (3)

Publication Number Publication Date
FI924503A FI924503A (fi) 1992-10-06
FI924503A0 FI924503A0 (fi) 1992-10-06
FI120348B true FI120348B (fi) 2009-09-30

Family

ID=24618783

Family Applications (2)

Application Number Title Priority Date Filing Date
FI924503A FI120348B (fi) 1991-02-08 1992-10-06 Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi
FI20050027A FI120690B (fi) 1991-02-08 2005-01-11 Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20050027A FI120690B (fi) 1991-02-08 2005-01-11 Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita

Country Status (19)

Country Link
US (3) US5240913A (da)
EP (1) EP0529031B9 (da)
JP (1) JPH05506252A (da)
KR (1) KR100259759B1 (da)
AT (1) ATE193325T1 (da)
AU (1) AU659828B2 (da)
BG (1) BG61243B2 (da)
CA (1) CA2079778C (da)
DE (1) DE69231081T2 (da)
DK (1) DK0529031T3 (da)
ES (1) ES2149170T3 (da)
FI (2) FI120348B (da)
GR (1) GR3034257T3 (da)
HK (1) HK1005995A1 (da)
HU (1) HU218831B (da)
NO (1) NO315710B1 (da)
NZ (1) NZ241557A (da)
TW (1) TW222642B (da)
WO (1) WO1992013952A1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
WO1995017907A1 (en) * 1993-12-27 1995-07-06 Hamilton Civic Hospitals Research Development, Inc. Methods and compositions for inhibiting thrombogenesis
WO1995019359A1 (en) * 1994-01-12 1995-07-20 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US6759384B1 (en) 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
DE4430204A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
DE4430205A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
US5747453A (en) * 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
JPH1010784A (ja) * 1996-06-27 1998-01-16 Brother Ind Ltd 正帯電性一成分現像剤並びにその現像剤を用いた画像形成装置
GB9613719D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Serine protease inhibitors
GB9613718D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
DE10162521A1 (de) * 2001-12-19 2003-07-17 Goetz Nowak Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
AR073360A1 (es) * 2008-09-03 2010-11-03 Scinopharm Taiwan Ltd Proceso para elaborar bivalirudina
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
DK3464336T3 (da) 2016-06-01 2022-05-09 Athira Pharma Inc Forbindelser
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US11992514B2 (en) 2019-05-20 2024-05-28 MAIA Pharmaceuticals, Inc. Ready-to-use bivalirudin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3501107A1 (de) * 1985-01-15 1986-07-17 Josef 8358 Vilshofen Paul Nutzfahrzeug mit schieberahmenwechselaufbau
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
ZA883444B (da) * 1987-05-21 1988-11-16
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
JPH04500802A (ja) * 1988-09-29 1992-02-13 バイオジェン インコーポレイテッド ヒルジンペプチド
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
AU654820B2 (en) * 1990-06-15 1994-11-24 Majesty (Her) In Right Of Canada As Represented By The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin

Also Published As

Publication number Publication date
FI20050027A (fi) 2005-01-11
NO923889L (no) 1992-12-08
EP0529031A1 (en) 1993-03-03
WO1992013952A1 (en) 1992-08-20
DE69231081D1 (de) 2000-06-29
ATE193325T1 (de) 2000-06-15
NZ241557A (en) 1996-11-26
ES2149170T3 (es) 2000-11-01
DE69231081T2 (de) 2001-02-01
HUT65675A (en) 1994-07-28
HK1005995A1 (en) 1999-02-05
FI924503A (fi) 1992-10-06
CA2079778A1 (en) 1992-08-09
DK0529031T3 (da) 2000-10-09
US5425936A (en) 1995-06-20
NO315710B1 (no) 2003-10-13
FI120690B (fi) 2010-01-29
KR100259759B1 (ko) 2000-06-15
AU1362192A (en) 1992-09-07
HU9203500D0 (en) 1993-01-28
FI924503A0 (fi) 1992-10-06
TW222642B (da) 1994-04-21
NO923889D0 (no) 1992-10-07
US5514409A (en) 1996-05-07
GR3034257T3 (en) 2000-12-29
CA2079778C (en) 2002-09-03
EP0529031B1 (en) 2000-05-24
EP0529031B9 (en) 2007-11-21
HU218831B (hu) 2000-12-28
BG61243B2 (bg) 1997-03-31
US5240913A (en) 1993-08-31
AU659828B2 (en) 1995-06-01
JPH05506252A (ja) 1993-09-16

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