TW222642B - - Google Patents

Info

Publication number
TW222642B
TW222642B TW081101012A TW81101012A TW222642B TW 222642 B TW222642 B TW 222642B TW 081101012 A TW081101012 A TW 081101012A TW 81101012 A TW81101012 A TW 81101012A TW 222642 B TW222642 B TW 222642B
Authority
TW
Taiwan
Prior art keywords
substituted
atoms
bond
group
backbone chain
Prior art date
Application number
TW081101012A
Other languages
English (en)
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Application granted granted Critical
Publication of TW222642B publication Critical patent/TW222642B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Manipulator (AREA)
TW081101012A 1991-02-08 1992-02-13 TW222642B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/652,929 US5240913A (en) 1989-08-18 1991-02-08 Inhibitors of thrombin

Publications (1)

Publication Number Publication Date
TW222642B true TW222642B (zh) 1994-04-21

Family

ID=24618783

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081101012A TW222642B (zh) 1991-02-08 1992-02-13

Country Status (19)

Country Link
US (3) US5240913A (zh)
EP (1) EP0529031B9 (zh)
JP (1) JPH05506252A (zh)
KR (1) KR100259759B1 (zh)
AT (1) ATE193325T1 (zh)
AU (1) AU659828B2 (zh)
BG (1) BG61243B2 (zh)
CA (1) CA2079778C (zh)
DE (1) DE69231081T2 (zh)
DK (1) DK0529031T3 (zh)
ES (1) ES2149170T3 (zh)
FI (2) FI120348B (zh)
GR (1) GR3034257T3 (zh)
HK (1) HK1005995A1 (zh)
HU (1) HU218831B (zh)
NO (1) NO315710B1 (zh)
NZ (1) NZ241557A (zh)
TW (1) TW222642B (zh)
WO (1) WO1992013952A1 (zh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
AU1378495A (en) * 1993-12-27 1995-07-17 Hamilton Civic Hospitals Research Development, Inc. Methods and compositions for inhibiting thrombogenesis
AU1562895A (en) * 1994-01-12 1995-08-01 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors
US5510330A (en) † 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
US6759384B1 (en) 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
DE4430204A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
DE4430205A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
US5747453A (en) 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
JPH1010784A (ja) * 1996-06-27 1998-01-16 Brother Ind Ltd 正帯電性一成分現像剤並びにその現像剤を用いた画像形成装置
GB9613718D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
GB9613719D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Serine protease inhibitors
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
DE10162521A1 (de) * 2001-12-19 2003-07-17 Goetz Nowak Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
JP2012502045A (ja) 2008-09-03 2012-01-26 サイノファーム タイワン リミテッド プラムリンチドの製造方法
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
CA3026074A1 (en) 2016-06-01 2017-12-07 M3 Biotechnology, Inc. N-hexanoic-l-tyrosine-l-isoleucine-(6)-aminohexanoic amide compounds and their use to treat neurodegenerative diseases
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US11992514B2 (en) 2019-05-20 2024-05-28 MAIA Pharmaceuticals, Inc. Ready-to-use bivalirudin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3501107A1 (de) * 1985-01-15 1986-07-17 Josef 8358 Vilshofen Paul Nutzfahrzeug mit schieberahmenwechselaufbau
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides
ZA883444B (zh) * 1987-05-21 1988-11-16
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
HUT55799A (en) * 1988-09-29 1991-06-28 Biogen Inc Process for producing hirudine-like peptides
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
JP2669510B2 (ja) * 1990-06-15 1997-10-29 ナショナル・リサーチ・カウンシル・オブ カナダ ヒルジンのアミノ酸配列に基づくトロンビン阻害剤

Also Published As

Publication number Publication date
DE69231081T2 (de) 2001-02-01
CA2079778C (en) 2002-09-03
AU659828B2 (en) 1995-06-01
ES2149170T3 (es) 2000-11-01
KR100259759B1 (ko) 2000-06-15
US5514409A (en) 1996-05-07
NO315710B1 (no) 2003-10-13
FI120690B (fi) 2010-01-29
HK1005995A1 (en) 1999-02-05
EP0529031B9 (en) 2007-11-21
DK0529031T3 (da) 2000-10-09
US5425936A (en) 1995-06-20
FI20050027A (fi) 2005-01-11
AU1362192A (en) 1992-09-07
NO923889L (no) 1992-12-08
US5240913A (en) 1993-08-31
FI924503A0 (fi) 1992-10-06
DE69231081D1 (de) 2000-06-29
WO1992013952A1 (en) 1992-08-20
NO923889D0 (no) 1992-10-07
EP0529031A1 (en) 1993-03-03
EP0529031B1 (en) 2000-05-24
HU9203500D0 (en) 1993-01-28
FI120348B (fi) 2009-09-30
NZ241557A (en) 1996-11-26
CA2079778A1 (en) 1992-08-09
GR3034257T3 (en) 2000-12-29
HU218831B (hu) 2000-12-28
HUT65675A (en) 1994-07-28
JPH05506252A (ja) 1993-09-16
FI924503A (fi) 1992-10-06
ATE193325T1 (de) 2000-06-15
BG61243B2 (bg) 1997-03-31

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