FI120150B - Glykoproteiinihormonikvartetin yksiketjumuotoja - Google Patents

Glykoproteiinihormonikvartetin yksiketjumuotoja Download PDF

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Publication number
FI120150B
FI120150B FI961600A FI961600A FI120150B FI 120150 B FI120150 B FI 120150B FI 961600 A FI961600 A FI 961600A FI 961600 A FI961600 A FI 961600A FI 120150 B FI120150 B FI 120150B
Authority
FI
Finland
Prior art keywords
ctp
subunit
agonist
antagonist
subunits
Prior art date
Application number
FI961600A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI961600A (fi
FI961600A0 (fi
Inventor
Irving Boime
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of FI961600A publication Critical patent/FI961600A/fi
Publication of FI961600A0 publication Critical patent/FI961600A0/fi
Application granted granted Critical
Publication of FI120150B publication Critical patent/FI120150B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI961600A 1994-08-12 1996-04-11 Glykoproteiinihormonikvartetin yksiketjumuotoja FI120150B (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US28939694A 1994-08-12 1994-08-12
US28939694 1994-08-12
US31059094A 1994-09-22 1994-09-22
US31059094 1994-09-22
US33462994A 1994-11-04 1994-11-04
US33462994 1994-11-04
US35159194A 1994-12-07 1994-12-07
US35159194 1994-12-07
PCT/US1995/009664 WO1996005224A1 (en) 1994-08-12 1995-08-01 Single-chain forms of the glycoprotein hormone quartet
US9509664 1995-08-01

Publications (3)

Publication Number Publication Date
FI961600A FI961600A (fi) 1996-04-11
FI961600A0 FI961600A0 (fi) 1996-04-11
FI120150B true FI120150B (fi) 2009-07-15

Family

ID=27501506

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961600A FI120150B (fi) 1994-08-12 1996-04-11 Glykoproteiinihormonikvartetin yksiketjumuotoja

Country Status (14)

Country Link
EP (1) EP0725795B1 (hu)
KR (1) KR960704932A (hu)
CN (1) CN1157408C (hu)
AT (1) ATE257843T1 (hu)
AU (1) AU703718B2 (hu)
CA (1) CA2173750C (hu)
DE (1) DE69532436T2 (hu)
DK (1) DK0725795T3 (hu)
ES (1) ES2210307T3 (hu)
FI (1) FI120150B (hu)
HU (1) HU227311B1 (hu)
NO (1) NO317394B1 (hu)
PT (1) PT725795E (hu)
WO (1) WO1996005224A1 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1849802A2 (en) * 1994-02-18 2007-10-31 Laboratoires Serono SA Methods for altering fertility
EP0974599A4 (en) * 1996-11-12 2002-06-12 Teikoku Hormone Mfg Co Ltd EQUINE, SINGLE-STRANDED AND RECOMBINANT CHORIONIC GONADOTROPHIN
US5883073A (en) * 1997-04-03 1999-03-16 Washington University Single-chain double-alpha peptide
US6693074B1 (en) * 1997-09-19 2004-02-17 Washington University Cystine depleted glycoprotein hormones
CN1277633A (zh) * 1997-09-22 2000-12-20 马里兰大学巴尔的摩分校 促甲状腺激素的突变体及其制备方法
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
JP2003524381A (ja) * 1998-09-22 2003-08-19 ユニヴァーシティ オブ メリーランド,ボルチモア システインノット成長因子ミュータント
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
IL154297A0 (en) * 2000-08-11 2003-09-17 Applied Res Glycoproteins, their preparation and use
WO2002036626A1 (en) * 2000-11-02 2002-05-10 Maxygen Aps Single-chain multimeric polypeptides
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
EP2161281A1 (en) * 2004-09-02 2010-03-10 Eli Lilly & Company Muteins of fibroblast growth factor 21
US9353172B2 (en) 2011-07-18 2016-05-31 Arts Biologics A/S Long acting biologically active luteinizing hormone (LH) compound
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN103539862B (zh) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 一种长效重组促卵泡激素及其应用
CN103539860B (zh) 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
BR102016006222A2 (pt) * 2016-03-22 2017-09-26 Universidade De São Paulo - Usp Process of production and purification of recombinant hydrogen hydrogen hybrid or non-hybrid, recombinant hydrogen hydrogen hybrids or non-hybrid, vectors of expression, and uses of recombinant glicoprotetic hormones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10199028I2 (de) * 1983-11-02 2004-07-01 Applied Research Systems Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit.
AU648020B2 (en) * 1989-02-21 1994-04-14 Washington University Modified forms of reproductive hormones
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
DE69131978T2 (de) * 1990-05-08 2000-10-05 University Of Medicine And Dentistry Of New Jersey, Newark Glykoproteinhormon-analoga mit veränderten immunologischen merkmalen, veränderter wirksamkeit und/oder rezeptorspezifität

Also Published As

Publication number Publication date
CA2173750A1 (en) 1996-02-22
FI961600A (fi) 1996-04-11
ES2210307T3 (es) 2004-07-01
NO961433L (no) 1996-06-11
EP0725795A1 (en) 1996-08-14
HU227311B1 (en) 2011-03-28
DE69532436T2 (de) 2004-11-25
HUT75900A (en) 1997-05-28
DK0725795T3 (da) 2004-05-17
AU3206695A (en) 1996-03-07
CN1157408C (zh) 2004-07-14
CN1131952A (zh) 1996-09-25
DE69532436D1 (de) 2004-02-19
AU703718B2 (en) 1999-04-01
ATE257843T1 (de) 2004-01-15
KR960704932A (ko) 1996-10-09
WO1996005224A1 (en) 1996-02-22
NO317394B1 (no) 2004-10-25
EP0725795A4 (en) 1998-05-06
EP0725795B1 (en) 2004-01-14
NO961433D0 (no) 1996-04-11
CA2173750C (en) 2011-03-22
PT725795E (pt) 2004-05-31
FI961600A0 (fi) 1996-04-11

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FI120150B (fi) Glykoproteiinihormonikvartetin yksiketjumuotoja
US6103501A (en) Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
US6238890B1 (en) Single chain forms of the glycoprotein hormone quartet
US5958737A (en) Single-chain β subunit dimers of the glycoprotein hormones and recombinant materials related thereto
US6028177A (en) Methods of detecting single-chain forms of the glycoprotein hormone quartet
US6987172B2 (en) Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US5759818A (en) N-terminal CTP extended pharmaceutical peptides and proteins
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US5883073A (en) Single-chain double-alpha peptide
US6635256B1 (en) Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6689365B1 (en) Single-chain fertility hormones with fsh and LH activity
JP4334615B2 (ja) 糖タンパク質ホルモンカルテットの一本鎖形態

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