FI119476B - Heterologisten proteiinien ilmentäminen heikennetyissä bakteereissa käyttämällä htrA-promoottoreita - Google Patents

Heterologisten proteiinien ilmentäminen heikennetyissä bakteereissa käyttämällä htrA-promoottoreita Download PDF

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Publication number
FI119476B
FI119476B FI963016A FI963016A FI119476B FI 119476 B FI119476 B FI 119476B FI 963016 A FI963016 A FI 963016A FI 963016 A FI963016 A FI 963016A FI 119476 B FI119476 B FI 119476B
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FI
Finland
Prior art keywords
vaccine composition
htra
promoter
dna
vaccine
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Application number
FI963016A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963016A0 (fi
FI963016A (fi
Inventor
Steven Neville Chatfield
Mohammed Anjam Khan
Jingli Li
Original Assignee
Peptide Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Peptide Therapeutics Ltd filed Critical Peptide Therapeutics Ltd
Publication of FI963016A0 publication Critical patent/FI963016A0/fi
Publication of FI963016A publication Critical patent/FI963016A/fi
Application granted granted Critical
Publication of FI119476B publication Critical patent/FI119476B/fi

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/08Clostridium, e.g. Clostridium tetani
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI963016A 1994-01-31 1996-07-30 Heterologisten proteiinien ilmentäminen heikennetyissä bakteereissa käyttämällä htrA-promoottoreita FI119476B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9401795A GB9401795D0 (en) 1994-01-31 1994-01-31 Vaccines
GB9401795 1994-01-31
GB9500196 1995-01-31
PCT/GB1995/000196 WO1995020665A1 (en) 1994-01-31 1995-01-31 Expression of heterologous proteins in attenuated bacteria using the htra-promoters

Publications (3)

Publication Number Publication Date
FI963016A0 FI963016A0 (fi) 1996-07-30
FI963016A FI963016A (fi) 1996-09-25
FI119476B true FI119476B (fi) 2008-11-28

Family

ID=10749598

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963016A FI119476B (fi) 1994-01-31 1996-07-30 Heterologisten proteiinien ilmentäminen heikennetyissä bakteereissa käyttämällä htrA-promoottoreita

Country Status (19)

Country Link
EP (1) EP0742829B1 (pt)
JP (1) JP3731004B2 (pt)
KR (1) KR100392916B1 (pt)
AT (1) ATE254178T1 (pt)
AU (1) AU701384B2 (pt)
BR (1) BR9506666A (pt)
CA (1) CA2182315C (pt)
CZ (1) CZ285867B6 (pt)
DE (1) DE69532109T2 (pt)
DK (1) DK0742829T3 (pt)
ES (1) ES2210283T3 (pt)
FI (1) FI119476B (pt)
GB (1) GB9401795D0 (pt)
HU (1) HU222982B1 (pt)
NZ (1) NZ278930A (pt)
PL (1) PL180091B1 (pt)
PT (1) PT742829E (pt)
SK (1) SK99696A3 (pt)
WO (1) WO1995020665A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9720033D0 (en) * 1997-09-19 1997-11-19 Medeva Plc Hepatitis B virus polypeptides
US20020168771A1 (en) * 2001-05-08 2002-11-14 Gamerman Gary Eric Vectors having replication, immunogenicity and/or pathogenicity under stress promoter regulation and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE109008T1 (de) * 1988-02-01 1994-08-15 Praxis Biolog Inc T-zellen-epitope als träger für einen konjugierten impfstoff.
CA2031468A1 (en) * 1989-12-08 1991-06-09 Mitchell S. Gross Malaria vaccine
GB9007194D0 (en) * 1990-03-30 1990-05-30 Wellcome Found Live vaccines
KR100240182B1 (ko) * 1991-03-05 2000-01-15 레슬리 제인 에드워즈 재조합 단백질을 발헨하는 약독해진 박테리아를 함유하는 백신
KR950702635A (ko) * 1992-07-31 1995-07-29 크리스틴 헬렌 수덴 감쇠 박테리아에서 재조합 융합 단백질의 발현(Expression of recombinant fusion proteins in attenuated bacteria)

Also Published As

Publication number Publication date
PL315670A1 (en) 1996-11-25
AU701384B2 (en) 1999-01-28
BR9506666A (pt) 1997-09-09
FI963016A0 (fi) 1996-07-30
DE69532109T2 (de) 2004-08-26
EP0742829A1 (en) 1996-11-20
PL180091B1 (pl) 2000-12-29
CA2182315A1 (en) 1995-08-03
JP3731004B2 (ja) 2006-01-05
EP0742829B1 (en) 2003-11-12
GB9401795D0 (en) 1994-03-23
CA2182315C (en) 2005-11-15
CZ285867B6 (cs) 1999-11-17
HU222982B1 (hu) 2004-01-28
ES2210283T3 (es) 2004-07-01
CZ218296A3 (en) 1996-10-16
DE69532109D1 (de) 2003-12-18
AU1541595A (en) 1995-08-15
PT742829E (pt) 2004-04-30
ATE254178T1 (de) 2003-11-15
HU9602084D0 (en) 1996-09-30
SK99696A3 (en) 1997-01-08
FI963016A (fi) 1996-09-25
NZ278930A (en) 1998-07-28
JPH09508276A (ja) 1997-08-26
WO1995020665A1 (en) 1995-08-03
KR100392916B1 (ko) 2003-10-22
DK0742829T3 (da) 2004-03-22
HUT75734A (en) 1997-05-28
KR970700770A (ko) 1997-02-12

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