FI119451B - Screening av graviditetsavvikelser före födseln - Google Patents
Screening av graviditetsavvikelser före födseln Download PDFInfo
- Publication number
- FI119451B FI119451B FI953830A FI953830A FI119451B FI 119451 B FI119451 B FI 119451B FI 953830 A FI953830 A FI 953830A FI 953830 A FI953830 A FI 953830A FI 119451 B FI119451 B FI 119451B
- Authority
- FI
- Finland
- Prior art keywords
- syndrome
- dimeric
- probability
- inhibin
- hcg
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Medical Informatics (AREA)
- Reproductive Health (AREA)
- Public Health (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Pregnancy & Childbirth (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Fire Alarms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (5)
1. Förfarande för att utvärdera riskerna för kro-mosomal avvikelse hos ett foster före födseln, kanne-5 tecknat av att man A) utvärderar den gravida patientens primära risk att förbära ett foster, som har nämnda kromosomala avvikelse, B) mäter koncentrationen av dimert inhibin i den 10 nämnda gravida patientens blod, C) räknar ut det normaliserade värdet för nämnda koncentration genom att dela nämnda koncentration med ett medianvärde, som erhällits hos en kvinnopopulation med normal graviditet och samma graviditetstid som nämnda gra- 15 vida patient, D) räknar ut en första sannolikhet för att det korrigerade, normaliserade värdet är en del av en Gauss-fördelning som erhällits i normala graviditeter, E) räknar ut en andra sannolikhet för att det kor-20 rigerade, normaliserade värdet är en del av en Gauss- fördelning som erhällits i graviditeter med nämnda kromo- • · · ϊ ί somala avvikelse, «·· ' :1·1: F) räknar ut ett sannolikhetsförhällande, som är • · ·1;1; nämnda första sannolikhet dividerad med nämnda andra san- • · 25 nolikhet, och • 1 • · • .·, G) modifierar den tidigare risken med sannolik- *♦!.1 hetsförhällandet. • · φ
• · · * 2. Förfarande enligt patentkrav 1, känneteck- . , nat av att man i steg B) i nämnda blodprov frän patienten • « · *·’·1 30 dessutom mäter koncentrationen av ett märkämne, vilket är ··· *...· intakt hCG, alfafetoprotein eller okonjugerad estriol. «
3. Förfarande enligt patentkrav 1, känneteck- • · .··1. nat av att den kromosomala avvikelsen är Downs syndrom, • · • · 1 t1 t trisomi 18, trisomi 13 eller Turners syndrom. « · · • M • · · • · · • ·· • · 119451
4. Förfarande enligt patentkrav 2, känneteck-nat av att den kromosomala avvikelsen är Downs syndrom, trisomi 18, trisomi 13 eller Turners syndrom.
5. Anordning, kännetecknad av att den inne-5 hcLller medel för att erhälla mätt pä dimert inhibin i en gravid patients blod och en dator, som är programmerad för att utföra förfarandet enligt patentkrav 1 för att utvär-dera riskerna före födseln. ··· • · • · ·· ·· 1 • < · • · • · • · • · m • · · • · ·· · • t · • · • · • · f · 1 • · 1 ··· · ♦ ·· « · 1 • · · ♦ · • · · » · • · ·1« * · • · ··« • · • · · • · · • · ··· t · • 1 ··· • · • ♦ · • ·· • f · • · · • ♦ · • ·
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9416415A GB9416415D0 (en) | 1994-08-13 | 1994-08-13 | Antenatel screening for pregnacy abnormalities |
GB9416415 | 1994-08-13 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI953830A0 FI953830A0 (sv) | 1995-08-11 |
FI953830A FI953830A (sv) | 1996-02-14 |
FI119451B true FI119451B (sv) | 2008-11-14 |
Family
ID=10759858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI953830A FI119451B (sv) | 1994-08-13 | 1995-08-11 | Screening av graviditetsavvikelser före födseln |
Country Status (10)
Country | Link |
---|---|
US (1) | US6022695A (sv) |
EP (1) | EP0701131B1 (sv) |
JP (1) | JP3626251B2 (sv) |
KR (1) | KR100389988B1 (sv) |
AT (1) | ATE213334T1 (sv) |
AU (1) | AU698204B2 (sv) |
CA (1) | CA2155919C (sv) |
DE (1) | DE69525400T2 (sv) |
FI (1) | FI119451B (sv) |
GB (1) | GB9416415D0 (sv) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9606261D0 (en) * | 1996-03-25 | 1996-05-29 | Johnson & Johnson Clin Diag | Prenatal screening for fetal abnormalities |
US6620590B2 (en) | 1996-07-11 | 2003-09-16 | Isis Innovation Limited | Diagnosis of pre-eclampsia |
GB9614615D0 (en) * | 1996-07-11 | 1996-09-04 | Isis Innovation | Diagnosis of pre-eclampsia |
CA2486089C (en) | 2002-05-15 | 2013-12-17 | Tommy J. Morris | System and method for handling medical information |
US20050131738A1 (en) * | 2002-05-15 | 2005-06-16 | Morris Tommy J. | System and method for handling medical information |
US7315787B2 (en) * | 2003-10-07 | 2008-01-01 | Ntd Laboratories, Inc. | Multi-marker screening protocol for fetal abnormalities |
JP2007521854A (ja) * | 2003-12-02 | 2007-08-09 | シュレイガ ロッテム | 母体−胎児状態の診断、スクリーニング、予防、及び治療のための人工知能及び装置 |
US20070249531A1 (en) * | 2004-02-20 | 2007-10-25 | Aplagen Gmbh | Method for the Detection of Autoantibodies Against Specific Peptides and Its Use in Diagnosis and Treatment of Pregnancy-Loss or Infertility |
ATE538217T1 (de) * | 2007-07-02 | 2012-01-15 | Univ Edinburgh | Erkennung von ektopischen schwangerschaften |
US20100027571A1 (en) * | 2008-07-31 | 2010-02-04 | Murdoch Keith M | Stabilized near-infrared laser |
WO2011144999A1 (en) | 2010-05-17 | 2011-11-24 | Sandra Reznik | Plasma protein-a2 (papp-a2) as a marker for detecting risk of chromosomal abnormalities |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4874693A (en) * | 1986-10-10 | 1989-10-17 | Mark Bogart | Method for assessing placental dysfunction |
ATE91182T1 (de) * | 1987-07-09 | 1993-07-15 | 3I Res Expl Ltd | Praenatales screening fuer downs-syndrom. |
GB8816714D0 (en) * | 1988-07-14 | 1988-08-17 | Univ Court Of University Of Gl | Switched reluctance motors |
ATE252240T1 (de) * | 1989-01-17 | 2003-11-15 | Jn Macri Technologies Llc Inc | Einrichtung zum nachweis vom down syndrom durch nichtinvasive siebtestung des mütterlichen blutes |
GB9224965D0 (en) * | 1992-11-28 | 1993-01-20 | Kodak Ltd | Antenatal screening for chromosomal abnormalities |
GB9410345D0 (en) * | 1994-05-24 | 1994-07-13 | Univ Oxford Brookes | Method of genetic testing |
US5716853A (en) * | 1995-07-07 | 1998-02-10 | Chiron Diagnostics Corporation | Prenatal down syndrome screening with assays specific for UGP |
-
1994
- 1994-08-13 GB GB9416415A patent/GB9416415D0/en active Pending
-
1995
- 1995-08-07 US US08/511,942 patent/US6022695A/en not_active Expired - Lifetime
- 1995-08-10 AU AU28487/95A patent/AU698204B2/en not_active Expired
- 1995-08-11 EP EP95305618A patent/EP0701131B1/en not_active Expired - Lifetime
- 1995-08-11 CA CA002155919A patent/CA2155919C/en not_active Expired - Lifetime
- 1995-08-11 JP JP20583995A patent/JP3626251B2/ja not_active Expired - Fee Related
- 1995-08-11 FI FI953830A patent/FI119451B/sv not_active IP Right Cessation
- 1995-08-11 DE DE69525400T patent/DE69525400T2/de not_active Expired - Lifetime
- 1995-08-11 AT AT95305618T patent/ATE213334T1/de not_active IP Right Cessation
- 1995-08-14 KR KR1019950024989A patent/KR100389988B1/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
KR100389988B1 (ko) | 2003-12-06 |
DE69525400T2 (de) | 2002-07-18 |
JPH09113508A (ja) | 1997-05-02 |
GB9416415D0 (en) | 1994-10-05 |
US6022695A (en) | 2000-02-08 |
ATE213334T1 (de) | 2002-02-15 |
EP0701131A2 (en) | 1996-03-13 |
FI953830A0 (sv) | 1995-08-11 |
DE69525400D1 (de) | 2002-03-21 |
CA2155919A1 (en) | 1996-02-14 |
KR960008312A (ko) | 1996-03-22 |
EP0701131B1 (en) | 2002-02-13 |
FI953830A (sv) | 1996-02-14 |
AU698204B2 (en) | 1998-10-29 |
JP3626251B2 (ja) | 2005-03-02 |
EP0701131A3 (en) | 1996-05-29 |
CA2155919C (en) | 2007-06-05 |
AU2848795A (en) | 1996-02-29 |
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Owner name: ORTHO-CLINICAL DIAGNOSTICS, INC. Free format text: ORTHO-CLINICAL DIAGNOSTICS, INC. |
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