FI115971B - 5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten - Google Patents

5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten Download PDF

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Publication number
FI115971B
FI115971B FI945323A FI945323A FI115971B FI 115971 B FI115971 B FI 115971B FI 945323 A FI945323 A FI 945323A FI 945323 A FI945323 A FI 945323A FI 115971 B FI115971 B FI 115971B
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FI
Finland
Prior art keywords
compound
solvate
methyluridine
nmpo
alcohol medium
Prior art date
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FI945323A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI945323A (fi
FI945323A0 (fi
Inventor
Bang-Chi Chen
Sandra L Quinlan
Derron Ray Stark
Stephen R Baker
Original Assignee
Squibb Bristol Myers Co
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Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of FI945323A0 publication Critical patent/FI945323A0/fi
Publication of FI945323A publication Critical patent/FI945323A/fi
Application granted granted Critical
Publication of FI115971B publication Critical patent/FI115971B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI945323A 1993-11-15 1994-11-11 5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten FI115971B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15305893A 1993-11-15 1993-11-15
US15277893A 1993-11-15 1993-11-15
US15305893 1993-11-15
US15277893 1993-11-15
US08/309,637 US5672698A (en) 1993-11-15 1994-09-23 Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US30963794 1994-09-23

Publications (3)

Publication Number Publication Date
FI945323A0 FI945323A0 (fi) 1994-11-11
FI945323A FI945323A (fi) 1995-05-16
FI115971B true FI115971B (fi) 2005-08-31

Family

ID=27387314

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945323A FI115971B (fi) 1993-11-15 1994-11-11 5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten

Country Status (17)

Country Link
US (1) US5672698A (fr)
EP (1) EP0653436B1 (fr)
JP (2) JP3653292B2 (fr)
KR (1) KR100329525B1 (fr)
CN (2) CN1040115C (fr)
AT (1) ATE162530T1 (fr)
AU (1) AU686672B2 (fr)
CA (1) CA2135852C (fr)
DE (1) DE69408099T2 (fr)
DK (1) DK0653436T3 (fr)
ES (1) ES2113626T3 (fr)
FI (1) FI115971B (fr)
GR (1) GR3026638T3 (fr)
HU (2) HU222118B1 (fr)
IL (1) IL111569A (fr)
SG (1) SG63554A1 (fr)
TW (1) TW291480B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US7034009B2 (en) * 1995-10-26 2006-04-25 Sirna Therapeutics, Inc. Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
US6482805B2 (en) 1998-03-25 2002-11-19 Parker Hughes Institute AZT derivatives exhibiting spermicidal and anti-viral activity
US6191120B1 (en) 1998-03-25 2001-02-20 Wayne Hughes Institute Spermicidally active 5-halo-6-alkoxy-5,6-dihydro-2′,3′-dideoxy-uridines and their pharamaceutical compositions
US6030957A (en) 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity
WO2002038576A1 (fr) * 2000-11-13 2002-05-16 Parker Hughes Institute Derives arylphosphate de d4t
US7144874B2 (en) * 2002-10-25 2006-12-05 Parker Hughes Institute Aryl phosphate derivatives of d4T having activity against resistant HIV strains
US20070015733A1 (en) * 1998-06-29 2007-01-18 Parker Hughes Institute Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
CN1055293C (zh) * 1998-10-06 2000-08-09 中国人民解放军第二军医大学 一种β-胸苷的制备方法
WO2002020538A2 (fr) * 2000-09-06 2002-03-14 Bristol-Myers Squibb Company Procede permettant d'obtenir la forme polymorphe de type i de la stavudine
US6825177B2 (en) * 2000-10-30 2004-11-30 Parker Hughes Institute Aryl phosphate derivatives of d4T with potent anti-viral activity
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20060046972A1 (en) * 2004-08-31 2006-03-02 Parker Hughes Institute Cytotoxic nucleoside analog compound 003 for treating cancer
CN102180925B (zh) * 2011-03-22 2013-05-08 苏州迪马生物科技发展有限公司 5-甲基尿苷合成工艺中乳化层的处理方法
CN104926902A (zh) * 2014-03-17 2015-09-23 张容霞 2`-取代-2,2`-脱水尿苷或2`-取代-2,2`-脱水胞苷化合物及其制备方法和用途
CN106967767B (zh) * 2017-04-25 2019-09-24 苏州笃美生物科技有限公司 一种β-胸苷的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
JP3128080B2 (ja) * 1991-10-02 2001-01-29 日本製紙株式会社 核酸化合物の新規な製造方法

Also Published As

Publication number Publication date
GR3026638T3 (en) 1998-07-31
US5672698A (en) 1997-09-30
EP0653436A1 (fr) 1995-05-17
HU222118B1 (hu) 2003-04-28
HU9403257D0 (en) 1995-01-30
CA2135852C (fr) 2006-01-03
CA2135852A1 (fr) 1995-05-16
AU686672B2 (en) 1998-02-12
DE69408099D1 (de) 1998-02-26
IL111569A0 (en) 1995-01-24
FI945323A (fi) 1995-05-16
DE69408099T2 (de) 1998-09-03
CN1112123A (zh) 1995-11-22
CN1040115C (zh) 1998-10-07
IL111569A (en) 2001-03-19
JP3653292B2 (ja) 2005-05-25
AU7880494A (en) 1995-06-01
CN1055477C (zh) 2000-08-16
TW291480B (fr) 1996-11-21
KR100329525B1 (ko) 2002-11-14
SG63554A1 (en) 1999-03-30
HUT69172A (en) 1995-08-28
JP2005139197A (ja) 2005-06-02
HU222119B1 (hu) 2003-04-28
FI945323A0 (fi) 1994-11-11
JPH07206856A (ja) 1995-08-08
KR950014132A (ko) 1995-06-15
ES2113626T3 (es) 1998-05-01
ATE162530T1 (de) 1998-02-15
CN1193021A (zh) 1998-09-16
DK0653436T3 (da) 1998-09-14
HU0105348D0 (en) 2002-02-28
EP0653436B1 (fr) 1998-01-21

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