ES2113626T3 - Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-3'-desoxitimidina (d4t) a partir de 5-metiluridina. - Google Patents

Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-3'-desoxitimidina (d4t) a partir de 5-metiluridina.

Info

Publication number
ES2113626T3
ES2113626T3 ES94402484T ES94402484T ES2113626T3 ES 2113626 T3 ES2113626 T3 ES 2113626T3 ES 94402484 T ES94402484 T ES 94402484T ES 94402484 T ES94402484 T ES 94402484T ES 2113626 T3 ES2113626 T3 ES 2113626T3
Authority
ES
Spain
Prior art keywords
methyluridine
deoxythymidine
procedure
dideshidro
scale preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94402484T
Other languages
English (en)
Inventor
Bang-Chi Chen
Derron R Stark
Stephen R Baker
Sandra L Quinlan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2113626T3 publication Critical patent/ES2113626T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN PROCESO ECONOMICO, SUJETO A UNA PRODUCCION A GRAN ESCALA, PARA LA PREPARACION DE 2'',3''-DIDESHIDRO-3''-DESOXITIMIDINA (D4T) A PARTIR DE 5-METILURIDINA. EN EL PROCESO SE UTILIZA UN NUEVO INTERMEDIO DE 5''-BENZOIL-2''(ALFA)-HALO-3''(ALFA)-ALCANOSULFONILTIMIDINA ASI COMO UNA PROCESO DE DESPROTECCION, AISLAMIETO Y PURIFICACION MUY EFICIENTE Y PRACTICO DEL PRODUCTO DE D4T.
ES94402484T 1993-11-15 1994-11-03 Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-3'-desoxitimidina (d4t) a partir de 5-metiluridina. Expired - Lifetime ES2113626T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15277893A 1993-11-15 1993-11-15
US15305893A 1993-11-15 1993-11-15
US08/309,637 US5672698A (en) 1993-11-15 1994-09-23 Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine

Publications (1)

Publication Number Publication Date
ES2113626T3 true ES2113626T3 (es) 1998-05-01

Family

ID=27387314

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94402484T Expired - Lifetime ES2113626T3 (es) 1993-11-15 1994-11-03 Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-3'-desoxitimidina (d4t) a partir de 5-metiluridina.

Country Status (17)

Country Link
US (1) US5672698A (es)
EP (1) EP0653436B1 (es)
JP (2) JP3653292B2 (es)
KR (1) KR100329525B1 (es)
CN (2) CN1040115C (es)
AT (1) ATE162530T1 (es)
AU (1) AU686672B2 (es)
CA (1) CA2135852C (es)
DE (1) DE69408099T2 (es)
DK (1) DK0653436T3 (es)
ES (1) ES2113626T3 (es)
FI (1) FI115971B (es)
GR (1) GR3026638T3 (es)
HU (2) HU222118B1 (es)
IL (1) IL111569A (es)
SG (1) SG63554A1 (es)
TW (1) TW291480B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US7034009B2 (en) * 1995-10-26 2006-04-25 Sirna Therapeutics, Inc. Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
US6482805B2 (en) 1998-03-25 2002-11-19 Parker Hughes Institute AZT derivatives exhibiting spermicidal and anti-viral activity
US6191120B1 (en) 1998-03-25 2001-02-20 Wayne Hughes Institute Spermicidally active 5-halo-6-alkoxy-5,6-dihydro-2′,3′-dideoxy-uridines and their pharamaceutical compositions
WO2002038576A1 (en) * 2000-11-13 2002-05-16 Parker Hughes Institute ARYL PHOSPHATE DERIVATIVES OF d4T
US7144874B2 (en) * 2002-10-25 2006-12-05 Parker Hughes Institute Aryl phosphate derivatives of d4T having activity against resistant HIV strains
US6030957A (en) * 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity
US20070015733A1 (en) * 1998-06-29 2007-01-18 Parker Hughes Institute Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
CN1055293C (zh) * 1998-10-06 2000-08-09 中国人民解放军第二军医大学 一种β-胸苷的制备方法
AU2001285197A1 (en) * 2000-09-06 2002-03-22 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
US6825177B2 (en) * 2000-10-30 2004-11-30 Parker Hughes Institute Aryl phosphate derivatives of d4T with potent anti-viral activity
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
WO2006026656A1 (en) * 2004-08-31 2006-03-09 Parker Hughes Institute Cytotoxic nucleoside analog compound 003 for treating cancer
CN102180925B (zh) * 2011-03-22 2013-05-08 苏州迪马生物科技发展有限公司 5-甲基尿苷合成工艺中乳化层的处理方法
CN104926902A (zh) * 2014-03-17 2015-09-23 张容霞 2`-取代-2,2`-脱水尿苷或2`-取代-2,2`-脱水胞苷化合物及其制备方法和用途
CN106967767B (zh) * 2017-04-25 2019-09-24 苏州笃美生物科技有限公司 一种β-胸苷的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
JP3128080B2 (ja) * 1991-10-02 2001-01-29 日本製紙株式会社 核酸化合物の新規な製造方法

Also Published As

Publication number Publication date
SG63554A1 (en) 1999-03-30
FI945323A0 (fi) 1994-11-11
EP0653436B1 (en) 1998-01-21
HU0105348D0 (en) 2002-02-28
DK0653436T3 (da) 1998-09-14
KR100329525B1 (ko) 2002-11-14
TW291480B (es) 1996-11-21
CN1040115C (zh) 1998-10-07
CN1055477C (zh) 2000-08-16
CN1193021A (zh) 1998-09-16
FI945323A (fi) 1995-05-16
GR3026638T3 (en) 1998-07-31
IL111569A0 (en) 1995-01-24
DE69408099T2 (de) 1998-09-03
JPH07206856A (ja) 1995-08-08
HU9403257D0 (en) 1995-01-30
JP3653292B2 (ja) 2005-05-25
AU686672B2 (en) 1998-02-12
EP0653436A1 (en) 1995-05-17
CN1112123A (zh) 1995-11-22
CA2135852C (en) 2006-01-03
KR950014132A (ko) 1995-06-15
DE69408099D1 (de) 1998-02-26
JP2005139197A (ja) 2005-06-02
HUT69172A (en) 1995-08-28
CA2135852A1 (en) 1995-05-16
FI115971B (fi) 2005-08-31
HU222119B1 (hu) 2003-04-28
AU7880494A (en) 1995-06-01
ATE162530T1 (de) 1998-02-15
HU222118B1 (hu) 2003-04-28
US5672698A (en) 1997-09-30
IL111569A (en) 2001-03-19

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