FI115770B - Menetelmä farmakologisesti aktiivisten peptidijohdannaisten valmistamiseksi - Google Patents

Menetelmä farmakologisesti aktiivisten peptidijohdannaisten valmistamiseksi Download PDF

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Publication number
FI115770B
FI115770B FI942645A FI942645A FI115770B FI 115770 B FI115770 B FI 115770B FI 942645 A FI942645 A FI 942645A FI 942645 A FI942645 A FI 942645A FI 115770 B FI115770 B FI 115770B
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FI
Finland
Prior art keywords
cha
pro
nag
hooc
pic
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FI942645A
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English (en)
Finnish (fi)
Swedish (sv)
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FI942645A (fi
FI942645A0 (fi
Inventor
Ann-Catrine Elis Teger-Nilsson
Ruth Elvy Bylund
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI942645A publication Critical patent/FI942645A/fi
Publication of FI942645A0 publication Critical patent/FI942645A0/fi
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Publication of FI115770B publication Critical patent/FI115770B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI942645A 1991-12-04 1994-06-03 Menetelmä farmakologisesti aktiivisten peptidijohdannaisten valmistamiseksi FI115770B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9103612 1991-12-04
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives
PCT/SE1992/000832 WO1993011152A1 (en) 1991-12-04 1992-12-01 New peptide derivatives
SE9200832 1992-12-01

Publications (3)

Publication Number Publication Date
FI942645A FI942645A (fi) 1994-06-03
FI942645A0 FI942645A0 (fi) 1994-06-03
FI115770B true FI115770B (fi) 2005-07-15

Family

ID=20384531

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942645A FI115770B (fi) 1991-12-04 1994-06-03 Menetelmä farmakologisesti aktiivisten peptidijohdannaisten valmistamiseksi

Country Status (27)

Country Link
US (4) US5614499A (ja)
EP (1) EP0618926B1 (ja)
JP (1) JP3306826B2 (ja)
CN (1) CN1076199A (ja)
AP (1) AP353A (ja)
AT (1) ATE190066T1 (ja)
AU (2) AU670052B2 (ja)
CA (1) CA2125175C (ja)
CZ (2) CZ333895A3 (ja)
DE (1) DE69230727T2 (ja)
EE (1) EE9400455A (ja)
FI (1) FI115770B (ja)
HU (1) HUT70431A (ja)
IL (1) IL103910A0 (ja)
IS (1) IS3954A (ja)
MA (1) MA22729A1 (ja)
MX (1) MX9206938A (ja)
NO (1) NO311361B1 (ja)
NZ (2) NZ280762A (ja)
SE (1) SE9103612D0 (ja)
SI (1) SI9200363A (ja)
SK (1) SK63194A3 (ja)
TN (1) TNSN92109A1 (ja)
TW (1) TW223078B (ja)
WO (1) WO1993011152A1 (ja)
YU (1) YU104592A (ja)
ZA (1) ZA929099B (ja)

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US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
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US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
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US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
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SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
BR9907112A (pt) 1998-01-26 2000-10-24 Basf Ag Composto, medicamento, e, uso de um composto
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SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
SE9802973D0 (sv) * 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
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KR20000060566A (ko) * 1999-03-17 2000-10-16 이경하 치환된 방향족 아미딘 유도체 및 이를 함유하는 의약조성물
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
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CN102924567B (zh) * 2008-10-28 2014-06-04 上海医药工业研究院 一类肽化合物、其制备方法及用途
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途
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RU2712194C1 (ru) * 2019-10-02 2020-01-27 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) Антикоагулянтное лекарственное средство, представляющее собой синтетический дипептид Ac-Trp-Arg-Pip ⋅HCl, фармацевтическая композиция, включающая это антикоагулянтное лекарственное средство

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Also Published As

Publication number Publication date
AU683793B2 (en) 1997-11-20
AU5061696A (en) 1996-08-01
FI942645A (fi) 1994-06-03
SI9200363A (en) 1993-06-30
NO311361B1 (no) 2001-11-19
AP353A (en) 1994-08-14
JP3306826B2 (ja) 2002-07-24
ZA929099B (en) 1993-06-07
ATE190066T1 (de) 2000-03-15
AU3120993A (en) 1993-06-28
HU9401474D0 (en) 1994-08-29
CN1076199A (zh) 1993-09-15
CZ129694A3 (en) 1994-12-15
MX9206938A (es) 1993-06-01
YU104592A (sh) 1995-12-04
JPH09500356A (ja) 1997-01-14
SE9103612D0 (sv) 1991-12-04
WO1993011152A1 (en) 1993-06-10
US5614499A (en) 1997-03-25
NO942066L (no) 1994-06-03
FI942645A0 (fi) 1994-06-03
AP9200457A0 (en) 1993-01-31
SK63194A3 (en) 1994-12-07
US5747460A (en) 1998-05-05
CA2125175C (en) 2001-09-11
TNSN92109A1 (fr) 1993-06-08
TW223078B (ja) 1994-05-01
EE9400455A (et) 1996-06-17
EP0618926B1 (en) 2000-03-01
EP0618926A1 (en) 1994-10-12
NZ280762A (en) 1998-08-26
IL103910A0 (en) 1993-04-04
NZ246106A (en) 1996-07-26
HUT70431A (en) 1995-10-30
IS3954A (is) 1993-06-05
MA22729A1 (fr) 1993-07-01
CZ333895A3 (en) 1996-04-17
NO942066D0 (no) 1994-06-03
US5955433A (en) 1999-09-21
CA2125175A1 (en) 1993-06-10
DE69230727T2 (de) 2000-08-03
DE69230727D1 (de) 2000-04-06
US5736521A (en) 1998-04-07
AU670052B2 (en) 1996-07-04

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