FI114342B - Menetelmä virtsan proteiinin ja kreatiniinin määrittämiseksi - Google Patents
Menetelmä virtsan proteiinin ja kreatiniinin määrittämiseksi Download PDFInfo
- Publication number
- FI114342B FI114342B FI945670A FI945670A FI114342B FI 114342 B FI114342 B FI 114342B FI 945670 A FI945670 A FI 945670A FI 945670 A FI945670 A FI 945670A FI 114342 B FI114342 B FI 114342B
- Authority
- FI
- Finland
- Prior art keywords
- creatinine
- reagent
- reaction
- urine
- protein
- Prior art date
Links
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title claims abstract description 172
- 229940109239 creatinine Drugs 0.000 title claims abstract description 86
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 47
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 22
- 230000002485 urinary effect Effects 0.000 title abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 51
- 238000003018 immunoassay Methods 0.000 claims abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 55
- 210000002700 urine Anatomy 0.000 claims description 43
- 238000003556 assay Methods 0.000 claims description 24
- VYWYYJYRVSBHJQ-UHFFFAOYSA-N 3,5-dinitrobenzoic acid Chemical compound OC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 VYWYYJYRVSBHJQ-UHFFFAOYSA-N 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 230000001900 immune effect Effects 0.000 claims description 5
- 239000012295 chemical reaction liquid Substances 0.000 claims description 2
- 238000007398 colorimetric assay Methods 0.000 claims description 2
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical group OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims 1
- 230000004520 agglutination Effects 0.000 abstract description 5
- 238000010924 continuous production Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 17
- 238000012360 testing method Methods 0.000 description 12
- 238000010521 absorption reaction Methods 0.000 description 9
- 239000000654 additive Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 8
- 239000000872 buffer Substances 0.000 description 8
- 238000002731 protein assay Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 239000007983 Tris buffer Substances 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- 230000000996 additive effect Effects 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 208000017169 kidney disease Diseases 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 206010027525 Microalbuminuria Diseases 0.000 description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000007430 reference method Methods 0.000 description 4
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000001103 potassium chloride Substances 0.000 description 3
- 235000011164 potassium chloride Nutrition 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 238000007818 agglutination assay Methods 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 108700004676 Bence Jones Proteins 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000012445 acidic reagent Substances 0.000 description 1
- 239000002535 acidifier Substances 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 239000012526 feed medium Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000001434 glomerular Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- IZXGZAJMDLJLMF-UHFFFAOYSA-N methylaminomethanol Chemical compound CNCO IZXGZAJMDLJLMF-UHFFFAOYSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- -1 α-1-20 microglobulin Proteins 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6827—Total protein determination, e.g. albumin in urine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/160,239 US5385847A (en) | 1993-12-02 | 1993-12-02 | Method for the determination of urinary protein and creatinine |
| US16023993 | 1993-12-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI945670A0 FI945670A0 (fi) | 1994-12-01 |
| FI945670A FI945670A (fi) | 1995-06-03 |
| FI114342B true FI114342B (fi) | 2004-09-30 |
Family
ID=22576091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI945670A FI114342B (fi) | 1993-12-02 | 1994-12-01 | Menetelmä virtsan proteiinin ja kreatiniinin määrittämiseksi |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5385847A (ko) |
| EP (1) | EP0656541B1 (ko) |
| JP (1) | JP3707814B2 (ko) |
| KR (1) | KR950019732A (ko) |
| AT (1) | ATE219248T1 (ko) |
| AU (1) | AU677106B2 (ko) |
| BR (1) | BR9404242A (ko) |
| CA (1) | CA2131146C (ko) |
| DE (1) | DE69430789T2 (ko) |
| ES (1) | ES2177560T3 (ko) |
| FI (1) | FI114342B (ko) |
| IL (1) | IL110220A (ko) |
| NO (1) | NO315957B1 (ko) |
| NZ (1) | NZ264209A (ko) |
| TW (1) | TW348216B (ko) |
| ZA (1) | ZA945837B (ko) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464777A (en) * | 1994-09-26 | 1995-11-07 | Miles Inc. | Dry reagent for creatinine assay |
| US5593895A (en) * | 1995-04-27 | 1997-01-14 | Bayer Corporation | Method for the detection of protein in urine |
| US5804452A (en) * | 1995-04-27 | 1998-09-08 | Quidel Corporation | One step urine creatinine assays |
| US5610073A (en) * | 1995-09-26 | 1997-03-11 | Bayer Corporation | Use of CO2 absorbant for stabilization of dried alkaline reagent in creatinine assay |
| KR100461987B1 (ko) * | 1995-12-06 | 2005-07-01 | 시스멕스 가부시키가이샤 | 데이터체크장치 |
| US5753517A (en) * | 1996-03-29 | 1998-05-19 | University Of British Columbia | Quantitative immunochromatographic assays |
| US5733787A (en) * | 1996-06-17 | 1998-03-31 | Bayer Corporation | Method for the detection of creatinine |
| DE19811196C2 (de) * | 1997-03-13 | 2002-05-08 | Imtec Immundiagnostika Gmbh | Verwendung von Anti-Creatinin-Antikörpern oder anderen Creatinin bindenden Substanz en zur Bestimmung von Creatinin in physiologischen Flüssigkeiten und Verfahren zu ihrer Herstellung |
| US5822071A (en) * | 1997-03-27 | 1998-10-13 | Bayer Corporation | Spectrometer normalization system |
| US6436721B1 (en) * | 1997-07-25 | 2002-08-20 | Bayer Corporation | Device and method for obtaining clinically significant analyte ratios |
| US6566051B1 (en) * | 1999-01-15 | 2003-05-20 | Medtox Scientific, Inc. | Lateral flow test strip |
| US6210971B1 (en) * | 1999-01-25 | 2001-04-03 | Bayer Corporation | Assay for the detection of creatinine |
| EP1072887B1 (en) * | 1999-07-30 | 2005-11-16 | Mitsubishi Chemical Corporation | Immunoassay |
| CA2397900A1 (en) * | 2000-01-21 | 2001-07-26 | Masayuki Yokoi | Method for quantitating creatinine discharged in urine, method for measuring urine component and apparatus therefor |
| WO2002046755A1 (fr) * | 2000-12-04 | 2002-06-13 | Matsushita Electric Industrial Co., Ltd. | Procede pour determiner la concentration d'une solution et procede d'analyse de l'urine |
| RS50219B (sr) | 2001-05-09 | 2009-07-15 | Axis-Shield Asa, | Sistem analize |
| WO2004048977A1 (de) * | 2002-11-25 | 2004-06-10 | Albert Missbichler | Verfahren zur detektion von membrangebundenen und/oder amyloidogenen proteinen |
| EP1715347B1 (en) * | 2004-01-23 | 2011-09-21 | ARKRAY, Inc. | Method of protein measurement |
| EP2196803B1 (en) * | 2007-09-27 | 2015-07-29 | Niigata University | Urine pretreatment agent for urinary protein determination, urine pretreatment method, and urinary protein determination method |
| JP6055236B2 (ja) * | 2011-08-17 | 2016-12-27 | 株式会社三和化学研究所 | 測定方法 |
| JP6055317B2 (ja) * | 2012-01-20 | 2016-12-27 | 株式会社三和化学研究所 | 糖化タンパク質及びタンパク質の測定方法 |
| US9804154B2 (en) | 2013-03-12 | 2017-10-31 | Epinex Diagnostics, Inc. | Rapid test for urine albumin and urine creatinine |
| CN105021544B (zh) | 2015-07-03 | 2018-02-02 | 艾康生物技术(杭州)有限公司 | 检测系统 |
| CN105013546B (zh) | 2015-07-03 | 2017-12-08 | 艾康生物技术(杭州)有限公司 | 生物样品反应盒 |
| AU2017339942B2 (en) | 2016-10-03 | 2023-06-29 | Dompe Farmaceutici S.P.A. | Prevention and treatment of diabetic nephropathy |
| WO2019139980A1 (en) | 2018-01-09 | 2019-07-18 | Idexx Laboratories, Inc. | Methods for measuring analyte and/or protein in biological samples |
| AU2019302359B2 (en) * | 2018-07-13 | 2022-05-26 | Siemens Healthcare Diagnostics Inc. | Microalbumin creatinine assay detection flag and methods of production and use related thereto |
| CN112577940A (zh) * | 2019-09-30 | 2021-03-30 | 厦门大学 | 一种快速低成本定量检测尿液中肌酐浓度的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2785057A (en) * | 1953-12-08 | 1957-03-12 | Union Central Life Insurance C | Device for testing liquids |
| US3705013A (en) * | 1970-01-05 | 1972-12-05 | Xerox Corp | Analytical procedures and compositions therefor |
| US4205954A (en) * | 1978-05-26 | 1980-06-03 | Warner-Lambert Company | Kinetic latex agglutinometry |
| US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
| CA1183367A (en) * | 1981-09-24 | 1985-03-05 | Ali H. Eseifan | Optical analyzing method and system |
| US4990075A (en) * | 1988-04-11 | 1991-02-05 | Miles Inc. | Reaction vessel for performing sequential analytical assays |
| IL94408A0 (en) * | 1989-07-11 | 1991-03-10 | Miles Inc | Method,reaction cassette and kit for performing analytical assays |
| EP0580383A3 (en) * | 1992-07-20 | 1995-04-12 | Csir | Liquid analysis. |
| US5464777A (en) * | 1994-09-26 | 1995-11-07 | Miles Inc. | Dry reagent for creatinine assay |
-
1993
- 1993-12-02 US US08/160,239 patent/US5385847A/en not_active Expired - Lifetime
-
1994
- 1994-07-05 IL IL11022094A patent/IL110220A/xx not_active IP Right Cessation
- 1994-07-15 TW TW083106464A patent/TW348216B/zh active
- 1994-08-04 ZA ZA945837A patent/ZA945837B/xx unknown
- 1994-08-09 NZ NZ264209A patent/NZ264209A/en unknown
- 1994-08-12 NO NO19942987A patent/NO315957B1/no unknown
- 1994-08-30 CA CA002131146A patent/CA2131146C/en not_active Expired - Fee Related
- 1994-08-30 KR KR1019940021492A patent/KR950019732A/ko not_active Application Discontinuation
- 1994-10-25 BR BR9404242A patent/BR9404242A/pt not_active IP Right Cessation
- 1994-11-21 AT AT94118288T patent/ATE219248T1/de not_active IP Right Cessation
- 1994-11-21 EP EP94118288A patent/EP0656541B1/en not_active Expired - Lifetime
- 1994-11-21 ES ES94118288T patent/ES2177560T3/es not_active Expired - Lifetime
- 1994-11-21 DE DE69430789T patent/DE69430789T2/de not_active Expired - Lifetime
- 1994-11-30 AU AU79150/94A patent/AU677106B2/en not_active Ceased
- 1994-12-01 FI FI945670A patent/FI114342B/fi not_active IP Right Cessation
- 1994-12-01 JP JP29829994A patent/JP3707814B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| TW348216B (en) | 1998-12-21 |
| NO315957B1 (no) | 2003-11-17 |
| IL110220A (en) | 1999-04-11 |
| AU7915094A (en) | 1995-06-08 |
| DE69430789D1 (de) | 2002-07-18 |
| FI945670A (fi) | 1995-06-03 |
| IL110220A0 (en) | 1994-10-21 |
| ATE219248T1 (de) | 2002-06-15 |
| AU677106B2 (en) | 1997-04-10 |
| EP0656541B1 (en) | 2002-06-12 |
| JP3707814B2 (ja) | 2005-10-19 |
| KR950019732A (ko) | 1995-07-24 |
| EP0656541A2 (en) | 1995-06-07 |
| BR9404242A (pt) | 1995-07-25 |
| ES2177560T3 (es) | 2002-12-16 |
| NO942987L (no) | 1995-06-06 |
| NZ264209A (en) | 1996-04-26 |
| CA2131146A1 (en) | 1995-06-03 |
| EP0656541A3 (en) | 1996-08-28 |
| ZA945837B (en) | 1995-03-09 |
| FI945670A0 (fi) | 1994-12-01 |
| DE69430789T2 (de) | 2002-10-24 |
| JPH07198719A (ja) | 1995-08-01 |
| US5385847A (en) | 1995-01-31 |
| NO942987D0 (no) | 1994-08-12 |
| CA2131146C (en) | 2004-03-30 |
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