FI114140B - Ett bärarsystem innehållande definierade lipider - Google Patents

Ett bärarsystem innehållande definierade lipider Download PDF

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Publication number
FI114140B
FI114140B FI944441A FI944441A FI114140B FI 114140 B FI114140 B FI 114140B FI 944441 A FI944441 A FI 944441A FI 944441 A FI944441 A FI 944441A FI 114140 B FI114140 B FI 114140B
Authority
FI
Finland
Prior art keywords
lipid
mixture
lipids
apolar
polar
Prior art date
Application number
FI944441A
Other languages
English (en)
Finnish (fi)
Other versions
FI944441A0 (sv
FI944441A (sv
Inventor
Gert Ragnarsson
Per Tingvall
Haakan Nyqvist
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of FI944441A0 publication Critical patent/FI944441A0/sv
Publication of FI944441A publication Critical patent/FI944441A/sv
Application granted granted Critical
Publication of FI114140B publication Critical patent/FI114140B/sv

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Claims (6)

1. Bärarsystem för ätminstone en bioaktiv förening, vilket förmär bilda separata lipidpartiklar i en 10 interaktiv verkan med ett överskott vattenhaltigt medium, kännetecknat av att det bestär av ett definierat lipid-system vilket uppvisar ätminstone tvä lipidkomponenter, varvid ätminstone en av lipidkomponenterna är amfifatisk och polar och dess mängd utgör 5-50 vikt-% av systemet, 15 och ätminstone en av lipidkomponenterna är apolar och bestär av en monoglycerid som är en blandning som bestär av i huvudsak 8:0 kaprylat och 10:0 kaprat, och systemet innehäller valbart ett hydrofilt lösningsmedel.
2. System enligt patentkrav 1, kännetecknat av att det 20 hydrofila lösningsmedlet är vatten och/eller glycerol.
3. System enligt patentkrav 1 eller 2, kännetecknat av att de amfifatiska och polara lipidkomponenterna bildar j. dubbelskikt och väljs bland fosfolipider och glyko- ,lipider.
4. System enligt patentkrav 3, kännetecknat av att den v 1 amfifatiska och polara lipidkomponenten är fosfatidyl- kolin.
5. System enligt nägot av patentkraven 1-4, kännetecknat ’ av att den apolara lipiden dessutom omfattar di- eller 30 triglycerider, i vilka längden av keden av fettsyrakompo- : nenterna varierar frän sex tili aderton kolatomer.
6. System enligt patentkrav 5, kännetecknat av att den apolara lipidkomponenten dessutom omfattar en komponent som har valts bland följande: 114140 a) en triglycerid, vilken i huvudsak är en blandning som innehäller 8:0 kaprylat och 10:0 kaprat, och/eller b) en triglycerid, vilken i huvudsak är en blandning som innehäller 18:2 linoleat, 18:1 oleat och 16:0 palmitat 5 och blandningar av dessa. I i * ’ * * I l > ' * t ^ · * · • ♦ » • I » »
FI944441A 1992-03-27 1994-09-26 Ett bärarsystem innehållande definierade lipider FI114140B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9200952A SE9200952D0 (sv) 1992-03-27 1992-03-27 Pharmaceutical carrier system containing defined lipids
SE9200952 1992-03-27
PCT/SE1993/000257 WO1993019736A1 (en) 1992-03-27 1993-03-26 A pharmaceutical carrier system containing defined lipids
SE9300257 1993-03-26

Publications (3)

Publication Number Publication Date
FI944441A0 FI944441A0 (sv) 1994-09-26
FI944441A FI944441A (sv) 1994-09-26
FI114140B true FI114140B (sv) 2004-08-31

Family

ID=20385758

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944441A FI114140B (sv) 1992-03-27 1994-09-26 Ett bärarsystem innehållande definierade lipider

Country Status (10)

Country Link
US (1) US5635205A (sv)
EP (1) EP0636020B1 (sv)
JP (1) JPH07508708A (sv)
AT (1) ATE179885T1 (sv)
DE (1) DE69324914T2 (sv)
DK (1) DK0636020T3 (sv)
FI (1) FI114140B (sv)
NO (1) NO308984B1 (sv)
SE (1) SE9200952D0 (sv)
WO (1) WO1993019736A1 (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
SE9402453D0 (sv) * 1994-07-12 1994-07-12 Astra Ab New pharmaceutical preparation
DE4447287C1 (de) * 1994-12-30 1996-11-07 Cevc Gregor Präparat zum Wirkstofftransport durch Barrieren
DE69511418T2 (de) * 1995-10-28 2000-03-30 Braun Melsungen Ag Lokalanästhetika und/oder Zentralanalgetika enthaltende pharmazeutische Zusammensetzungen
WO1998047487A1 (en) * 1997-04-17 1998-10-29 Dumex-Alpharma A/S A novel bioadhesive drug delivery system based on liquid crystals
ATE535232T1 (de) 1997-09-18 2011-12-15 Pacira Pharmaceuticals Inc Retardierte freisetzung liposomaler anesthetischer zusammensetzungen
IL135989A0 (en) 1997-11-14 2001-05-20 Skyepharma Inc Processes for the production of multivesicular liposomes
US6277413B1 (en) 1998-07-17 2001-08-21 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
KR100638150B1 (ko) 1998-12-23 2006-10-26 이데아 악티엔게젤샤프트 생체내에서 국부적인 비침습성 용도로 사용되는 개선된 제제
SE0000730D0 (sv) * 2000-03-06 2000-03-06 Scotia Holdings Plc Lipid carrier
EP1395243A2 (en) * 2001-05-31 2004-03-10 SkyePharma Inc. Encapsulation of nanosuspensions in liposomes and microspheres
US8920843B2 (en) * 2007-11-07 2014-12-30 Svip5 Llc Slow release of organic salts of local anesthetics for pain relief
CN102892408A (zh) * 2010-04-01 2013-01-23 帕玛内斯特公司 适于局部麻醉剂的无水药物组合物
IN2014MN02213A (sv) 2012-05-10 2015-07-10 Painreform Ltd
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
CA2903020C (en) 2013-02-28 2019-06-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compostions
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3585967D1 (de) * 1984-03-08 1992-06-11 Phares Pharma Holland Liposombildende zusammensetzung.
GB8613811D0 (en) * 1986-06-06 1986-07-09 Phares Pharm Res Nv Composition & method
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
SE9003100D0 (sv) * 1990-09-28 1990-09-28 Kabivitrum Ab Lipid formulation system

Also Published As

Publication number Publication date
EP0636020A1 (en) 1995-02-01
DE69324914D1 (de) 1999-06-17
SE9200952D0 (sv) 1992-03-27
FI944441A0 (sv) 1994-09-26
US5635205A (en) 1997-06-03
DE69324914T2 (de) 1999-12-09
NO943543L (no) 1994-09-23
NO943543D0 (no) 1994-09-23
ATE179885T1 (de) 1999-05-15
EP0636020B1 (en) 1999-05-12
DK0636020T3 (da) 1999-11-15
JPH07508708A (ja) 1995-09-28
NO308984B1 (no) 2000-11-27
WO1993019736A1 (en) 1993-10-14
FI944441A (sv) 1994-09-26

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