FI113965B - 8-okso-4-oksa-1,7-diatsatrisyklo-oktadekatetraen-9-yylikarbamoyylijohdannaiset matriisimetalloproteaasi-inhibiittoreina - Google Patents
8-okso-4-oksa-1,7-diatsatrisyklo-oktadekatetraen-9-yylikarbamoyylijohdannaiset matriisimetalloproteaasi-inhibiittoreina Download PDFInfo
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- FI113965B FI113965B FI973198A FI973198A FI113965B FI 113965 B FI113965 B FI 113965B FI 973198 A FI973198 A FI 973198A FI 973198 A FI973198 A FI 973198A FI 113965 B FI113965 B FI 113965B
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- oxa
- oxo
- tricyclo
- diaza
- octadeca
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- 125000006253 t-butylcarbonyl group Chemical group [H]C([H])([H])C(C(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000000454 talc Chemical class 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- BNWCETAHAJSBFG-UHFFFAOYSA-N tert-butyl 2-bromoacetate Chemical compound CC(C)(C)OC(=O)CBr BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Substances [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 125000005490 tosylate group Chemical group 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000004325 uterine smooth muscle cell Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38281895 | 1995-02-03 | ||
| US08/382,818 US6013792A (en) | 1993-08-05 | 1995-02-03 | Matrix metalloprotease inhibitors |
| PCT/US1996/001506 WO1996023791A1 (en) | 1995-02-03 | 1996-02-02 | Bridged indoles as matrix metalloprotease inhibitors |
| US9601506 | 1996-02-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI973198A FI973198A (fi) | 1997-08-01 |
| FI973198A0 FI973198A0 (fi) | 1997-08-01 |
| FI113965B true FI113965B (fi) | 2004-07-15 |
Family
ID=23510527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI973198A FI113965B (fi) | 1995-02-03 | 1997-08-01 | 8-okso-4-oksa-1,7-diatsatrisyklo-oktadekatetraen-9-yylikarbamoyylijohdannaiset matriisimetalloproteaasi-inhibiittoreina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6013792A (es) |
| EP (1) | EP0807114A1 (es) |
| JP (1) | JPH11500109A (es) |
| KR (1) | KR100403687B1 (es) |
| CN (1) | CN1066150C (es) |
| AR (1) | AR002958A1 (es) |
| AU (1) | AU705763B2 (es) |
| BR (1) | BR9606998A (es) |
| CA (1) | CA2212236A1 (es) |
| CZ (1) | CZ293868B6 (es) |
| FI (1) | FI113965B (es) |
| HU (1) | HUP9702073A3 (es) |
| NO (1) | NO311257B1 (es) |
| PL (1) | PL321659A1 (es) |
| RU (1) | RU2191779C2 (es) |
| UA (1) | UA67716C2 (es) |
| WO (1) | WO1996023791A1 (es) |
| ZA (1) | ZA96850B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU725831C (en) * | 1995-12-08 | 2002-10-17 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
| US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
| US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| GB9715030D0 (en) * | 1997-07-18 | 1997-09-24 | British Biotech Pharm | Metalloproteinase inhibitors |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| GB9907055D0 (en) * | 1999-03-29 | 1999-05-19 | British Biotech Pharm | Antibacterial agents |
| AR032920A1 (es) * | 2001-03-01 | 2003-12-03 | Smithkline Beecham Corp | Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores |
| UY27813A1 (es) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
| CN1732023A (zh) * | 2002-12-27 | 2006-02-08 | 血管技术国际股份公司 | 组合物和使用collajolie的方法 |
| EP2181704B1 (en) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| DE602004027000D1 (de) * | 2003-01-17 | 2010-06-17 | Advanced Proteome Therapeutics | Verfahren zur Identifizierung aktivierter Polymer-Komplexe zur sekundären Stellen-spezifischen Modifikation von Protein Ziel-Gruppen. |
| AU2003902115A0 (en) * | 2003-05-02 | 2003-05-22 | The University Of Queensland | Method of predicting functional outcome of a stroke using eeg measures |
| CA2533820C (en) * | 2003-07-31 | 2016-12-13 | Tranzyme Pharma | Spatially-defined macrocycles incorporating peptide bond surrogates |
| KR100753796B1 (ko) | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
| UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| CN105801530A (zh) * | 2016-04-13 | 2016-07-27 | 成都拿盛科技有限公司 | 一种4位取代的手性γ-丁内酯的合成方法 |
| KR20220105061A (ko) | 2021-01-19 | 2022-07-26 | (주)월드트렌드 | 밀착력과 착용감 향상 및 수시 교체가 가능한 안경테와 코 받침의 조립구조 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022117D0 (en) * | 1990-10-11 | 1990-11-21 | Beecham Group Plc | Novel compounds |
| EP0586537A4 (en) * | 1991-05-28 | 1997-06-25 | Merck & Co Inc | Substituted n-carboxyalkylpeptidyl derivatives as antidegenerative active agents |
| GB9122859D0 (en) * | 1991-10-28 | 1991-12-11 | Smithkline Beecham Plc | Novel compounds |
| ES2105744T3 (es) * | 1993-08-05 | 1997-10-16 | Syntex Inc | Inhibidores de metaloproteasas matriciales. |
-
1995
- 1995-02-03 US US08/382,818 patent/US6013792A/en not_active Expired - Fee Related
-
1996
- 1996-02-02 UA UA97094471A patent/UA67716C2/uk unknown
- 1996-02-02 AU AU48636/96A patent/AU705763B2/en not_active Ceased
- 1996-02-02 KR KR1019970705256A patent/KR100403687B1/ko not_active IP Right Cessation
- 1996-02-02 JP JP8523770A patent/JPH11500109A/ja not_active Ceased
- 1996-02-02 PL PL96321659A patent/PL321659A1/xx unknown
- 1996-02-02 HU HU9702073A patent/HUP9702073A3/hu unknown
- 1996-02-02 ZA ZA9600850A patent/ZA96850B/xx unknown
- 1996-02-02 CZ CZ19972431A patent/CZ293868B6/cs not_active IP Right Cessation
- 1996-02-02 WO PCT/US1996/001506 patent/WO1996023791A1/en not_active Application Discontinuation
- 1996-02-02 CA CA002212236A patent/CA2212236A1/en not_active Abandoned
- 1996-02-02 EP EP96904563A patent/EP0807114A1/en not_active Withdrawn
- 1996-02-02 BR BR9606998A patent/BR9606998A/pt not_active Application Discontinuation
- 1996-02-02 CN CN96192984A patent/CN1066150C/zh not_active Expired - Fee Related
- 1996-02-02 RU RU97115238/04A patent/RU2191779C2/ru not_active IP Right Cessation
- 1996-02-05 AR ARP960101275A patent/AR002958A1/es not_active Application Discontinuation
-
1997
- 1997-08-01 FI FI973198A patent/FI113965B/fi not_active IP Right Cessation
- 1997-08-01 NO NO19973551A patent/NO311257B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO311257B1 (no) | 2001-11-05 |
| BR9606998A (pt) | 1997-10-28 |
| FI973198A (fi) | 1997-08-01 |
| WO1996023791A1 (en) | 1996-08-08 |
| JPH11500109A (ja) | 1999-01-06 |
| AU4863696A (en) | 1996-08-21 |
| CN1066150C (zh) | 2001-05-23 |
| CN1180358A (zh) | 1998-04-29 |
| EP0807114A1 (en) | 1997-11-19 |
| CZ243197A3 (cs) | 1998-01-14 |
| HUP9702073A3 (en) | 1999-05-28 |
| UA67716C2 (en) | 2004-07-15 |
| US6013792A (en) | 2000-01-11 |
| FI973198A0 (fi) | 1997-08-01 |
| PL321659A1 (en) | 1997-12-22 |
| HUP9702073A2 (hu) | 1998-03-30 |
| ZA96850B (en) | 1997-11-03 |
| KR100403687B1 (ko) | 2004-02-11 |
| NO973551L (no) | 1997-10-03 |
| AU705763B2 (en) | 1999-06-03 |
| AR002958A1 (es) | 1998-05-27 |
| CA2212236A1 (en) | 1996-08-08 |
| CZ293868B6 (cs) | 2004-08-18 |
| NO973551D0 (no) | 1997-08-01 |
| RU2191779C2 (ru) | 2002-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |