FI111261B - Analogiförfarande för framställning av terapeutiskt användbara fosfolipidderivat - Google Patents
Analogiförfarande för framställning av terapeutiskt användbara fosfolipidderivat Download PDFInfo
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- FI111261B FI111261B FI934297A FI934297A FI111261B FI 111261 B FI111261 B FI 111261B FI 934297 A FI934297 A FI 934297A FI 934297 A FI934297 A FI 934297A FI 111261 B FI111261 B FI 111261B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 15
- 150000003904 phospholipids Chemical class 0.000 title claims abstract description 6
- 229910052785 arsenic Inorganic materials 0.000 claims abstract description 32
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 22
- 229910052787 antimony Inorganic materials 0.000 claims abstract description 8
- 229910052797 bismuth Inorganic materials 0.000 claims abstract description 3
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims description 69
- 150000002500 ions Chemical class 0.000 claims description 39
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- 238000000746 purification Methods 0.000 claims description 30
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- 239000002904 solvent Substances 0.000 claims description 20
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- 125000004430 oxygen atom Chemical group O* 0.000 claims description 7
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
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- 125000004434 sulfur atom Chemical group 0.000 claims description 4
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- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940117389 dichlorobenzene Drugs 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- PFUUSRPLVRBMDT-UHFFFAOYSA-M diethyl-(2-hydroxyethyl)-phenylphosphanium;bromide Chemical compound [Br-].OCC[P+](CC)(CC)C1=CC=CC=C1 PFUUSRPLVRBMDT-UHFFFAOYSA-M 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- XGFDHKJUZCCPKQ-UHFFFAOYSA-N n-nonadecyl alcohol Natural products CCCCCCCCCCCCCCCCCCCO XGFDHKJUZCCPKQ-UHFFFAOYSA-N 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- PMOIAJVKYNVHQE-UHFFFAOYSA-N phosphanium;bromide Chemical compound [PH4+].[Br-] PMOIAJVKYNVHQE-UHFFFAOYSA-N 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Inorganic materials [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/72—Aliphatic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4233044A DE4233044A1 (de) | 1992-10-01 | 1992-10-01 | Phospholipidderivate, die höhere Elemente der V. Hauptgruppe enthalten |
| DE4233044 | 1992-10-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI934297A0 FI934297A0 (fi) | 1993-09-30 |
| FI934297A FI934297A (fi) | 1994-04-02 |
| FI111261B true FI111261B (sv) | 2003-06-30 |
Family
ID=6469408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI934297A FI111261B (sv) | 1992-10-01 | 1993-09-30 | Analogiförfarande för framställning av terapeutiskt användbara fosfolipidderivat |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5449798A (sv) |
| EP (1) | EP0594999B1 (sv) |
| JP (1) | JP3688304B2 (sv) |
| KR (1) | KR100331367B1 (sv) |
| CN (1) | CN1055697C (sv) |
| AT (1) | ATE174030T1 (sv) |
| AU (1) | AU661795B2 (sv) |
| BR (1) | BR9303990A (sv) |
| CA (1) | CA2107439C (sv) |
| DE (2) | DE4233044A1 (sv) |
| DK (1) | DK0594999T3 (sv) |
| EG (1) | EG20258A (sv) |
| ES (1) | ES2125935T3 (sv) |
| FI (1) | FI111261B (sv) |
| GR (1) | GR3029423T3 (sv) |
| HU (1) | HU220593B1 (sv) |
| IL (1) | IL107141A (sv) |
| MX (1) | MX9306076A (sv) |
| NO (1) | NO305911B1 (sv) |
| PH (1) | PH29951A (sv) |
| RU (1) | RU2126413C1 (sv) |
| UA (1) | UA39163C2 (sv) |
| ZA (1) | ZA937282B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP026997A0 (en) | 1997-11-07 | 1997-12-04 | Resmed Limited | Administration of cpap treatment pressure in presence of apnea |
| US20060116354A1 (en) * | 2003-01-09 | 2006-06-01 | Perkins Walter R | Antineoplastic ether lipid compounds with modifications at the sn-3 carbon |
| AR058397A1 (es) | 2005-12-19 | 2008-01-30 | Zentaris Gmbh | Derivados de alquilfosfolipidos con citotoxicidad reducida y usos de los mismos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4177216A (en) * | 1974-06-21 | 1979-12-04 | The Dow Chemical Company | Novel tributyl (2,5-dihydroxyphenyl)phosphonium hydroxide inner salts |
| US4177716A (en) * | 1978-02-21 | 1979-12-11 | Gerald J. Bowe | Automatic energy saver and fire damper for exhaust systems |
| JPS5984824A (ja) * | 1982-11-08 | 1984-05-16 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
| EP0916343A1 (de) * | 1989-09-27 | 1999-05-19 | ASTA Medica Aktiengesellschaft | Verwendung von Alkylphosphorsäure-Verbindungen zur Bekämpfung von Psoriasis-Erkrankungen |
| DE3942933A1 (de) * | 1989-12-23 | 1991-06-27 | Boehringer Mannheim Gmbh | Verwendung von alkylphospholipiden als antivirale arzneimittel und neue phospholipid-derivate |
| DE4111105A1 (de) * | 1991-04-05 | 1992-10-08 | Max Planck Gesellschaft | Neue erucyl-, brassidyl- und nervonylderivate |
-
1992
- 1992-10-01 DE DE4233044A patent/DE4233044A1/de not_active Withdrawn
-
1993
- 1993-06-25 EG EG92893A patent/EG20258A/xx active
- 1993-09-13 DK DK93114671T patent/DK0594999T3/da active
- 1993-09-13 AT AT93114671T patent/ATE174030T1/de not_active IP Right Cessation
- 1993-09-13 ES ES93114671T patent/ES2125935T3/es not_active Expired - Lifetime
- 1993-09-13 DE DE59309182T patent/DE59309182D1/de not_active Expired - Fee Related
- 1993-09-13 EP EP93114671A patent/EP0594999B1/de not_active Expired - Lifetime
- 1993-09-22 US US08/124,492 patent/US5449798A/en not_active Expired - Lifetime
- 1993-09-28 IL IL107141A patent/IL107141A/en not_active IP Right Cessation
- 1993-09-28 CN CN93118218A patent/CN1055697C/zh not_active Expired - Fee Related
- 1993-09-28 KR KR1019930020113A patent/KR100331367B1/ko not_active IP Right Cessation
- 1993-09-30 ZA ZA937282A patent/ZA937282B/xx unknown
- 1993-09-30 CA CA002107439A patent/CA2107439C/en not_active Expired - Fee Related
- 1993-09-30 HU HU9302772A patent/HU220593B1/hu not_active IP Right Cessation
- 1993-09-30 BR BR9303990A patent/BR9303990A/pt not_active Application Discontinuation
- 1993-09-30 RU RU93054776A patent/RU2126413C1/ru not_active IP Right Cessation
- 1993-09-30 AU AU48747/93A patent/AU661795B2/en not_active Ceased
- 1993-09-30 NO NO933505A patent/NO305911B1/no unknown
- 1993-09-30 FI FI934297A patent/FI111261B/sv active
- 1993-09-30 PH PH46986A patent/PH29951A/en unknown
- 1993-09-30 MX MX9306076A patent/MX9306076A/es unknown
- 1993-09-30 UA UA93002238A patent/UA39163C2/uk unknown
- 1993-10-01 JP JP24683293A patent/JP3688304B2/ja not_active Expired - Fee Related
-
1995
- 1995-04-14 US US08/421,920 patent/US5637577A/en not_active Expired - Fee Related
-
1999
- 1999-02-17 GR GR990400506T patent/GR3029423T3/el unknown
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