FI111013B - Stabiileja purA-vektoreita ja niiden käyttö - Google Patents
Stabiileja purA-vektoreita ja niiden käyttö Download PDFInfo
- Publication number
- FI111013B FI111013B FI921940A FI921940A FI111013B FI 111013 B FI111013 B FI 111013B FI 921940 A FI921940 A FI 921940A FI 921940 A FI921940 A FI 921940A FI 111013 B FI111013 B FI 111013B
- Authority
- FI
- Finland
- Prior art keywords
- pura
- plasmid
- gene
- virus
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69570691A | 1991-05-03 | 1991-05-03 | |
US69570691 | 1991-05-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI921940A0 FI921940A0 (fi) | 1992-04-30 |
FI921940A FI921940A (fi) | 1992-11-04 |
FI111013B true FI111013B (fi) | 2003-05-15 |
Family
ID=24794162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI921940A FI111013B (fi) | 1991-05-03 | 1992-04-30 | Stabiileja purA-vektoreita ja niiden käyttö |
Country Status (16)
Country | Link |
---|---|
US (2) | US5919663A (fr) |
EP (1) | EP0512260B1 (fr) |
JP (1) | JP3320095B2 (fr) |
KR (1) | KR100242798B1 (fr) |
AT (1) | ATE202800T1 (fr) |
AU (1) | AU654347B2 (fr) |
CA (1) | CA2067862C (fr) |
DE (1) | DE69231907T2 (fr) |
DK (1) | DK0512260T3 (fr) |
ES (1) | ES2160573T3 (fr) |
FI (1) | FI111013B (fr) |
GR (1) | GR3036487T3 (fr) |
IL (1) | IL101751A0 (fr) |
NO (1) | NO314043B1 (fr) |
PT (1) | PT512260E (fr) |
TW (1) | TW201794B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7279313B2 (en) * | 1995-09-15 | 2007-10-09 | Centelion | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy |
FR2738842B1 (fr) * | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
BR9711658A (pt) * | 1996-09-04 | 1999-08-24 | Basf Ag | Cassete de expressÆo vetor recombinante microorganismo usos de um vetor de uma sequ-ncia de cido nucleico codificadora e de um kit de expressÆo planta transg-nica processo para a produ-Æo de plantas transg-nicas produto de expressÆo e kit de expressÆo |
EP0973865A2 (fr) * | 1997-04-11 | 2000-01-26 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vaccins vivants attenues diriges contre des ichtyopathogenes |
US6010705A (en) * | 1997-04-11 | 2000-01-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Attenuated, invasive vaccines against fish pathogens |
WO2000034498A1 (fr) * | 1998-12-04 | 2000-06-15 | University Of Manitoba | PROCEDURE D'IMMUNISATION EN DEUX ETAPES CONTRE L'INFECTION PAR$i(CHLAMYDIA) |
KR100427587B1 (ko) * | 2001-01-12 | 2004-04-27 | 주식회사 바이오리더스 | 신규 d-글루탐산 합성효소 유전자 dna 및 이를 이용한 항생제 비의존성 벡터 |
FI116851B (fi) * | 2001-05-03 | 2006-03-15 | Fit Biotech Oyj Plc | Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita |
US20040009937A1 (en) * | 2002-01-31 | 2004-01-15 | Wei Chen | Methods and composition for delivering nucleic acids and/or proteins to the respiratory system |
WO2003063786A2 (fr) * | 2002-01-31 | 2003-08-07 | Symbigene, Inc. | Methodes et compositions permettant de distribuer des acides nucleiques et/ou des proteines au systeme respiratoire |
CN1276076C (zh) * | 2004-12-14 | 2006-09-20 | 华东理工大学 | 一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用 |
WO2009025888A2 (fr) | 2007-05-10 | 2009-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Expression régulée d'antigène et/ou atténuation régulée pour accroître l'immunogénicité et/ou la sécurité de vaccins |
WO2008141226A2 (fr) * | 2007-05-10 | 2008-11-20 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactéries recombinantes comprenant des vecteurs pour l'expression de séquences d'acide nucléique codant des antigènes |
WO2009046449A1 (fr) | 2007-10-05 | 2009-04-09 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactéries recombinantes capables de susciter une réponse immunitaire contre des agents pathogènes entériques |
WO2010045620A1 (fr) * | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie recombinante pouvant éliciter une réponse immunitaire contre le streptococcus pneumoniae |
US9163219B2 (en) * | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
WO2010135563A1 (fr) | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie de recombinaison et méthodes d'administration d'antigène et d'acide nucléique |
US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
WO2011091291A1 (fr) | 2010-01-22 | 2011-07-28 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie renfermant un acide nucléique régulé par le rfah |
WO2011150421A2 (fr) | 2010-05-28 | 2011-12-01 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie recombinante permettant de diminuer la croissance tumorale |
WO2012082946A2 (fr) * | 2010-12-14 | 2012-06-21 | The Regents Of The University Of California | Création de plasmides de cole1 super-stables par duplication de la séquence sl 1-4 et mutations ponctuelles. |
US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
KR102006976B1 (ko) * | 2019-02-26 | 2019-08-06 | 씨제이제일제당 주식회사 | 신규 프로모터 및 이를 이용한 퓨린 뉴클레오티드 제조방법 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0025118A1 (fr) * | 1979-08-18 | 1981-03-18 | Riedlinger, Rainer, Dr.-Ing. | Dispositif pour la reproduction acoustique de signaux qui sont représentables au moyen de canaux stéréophoniques de droite et de gauche |
US4550081A (en) * | 1980-05-19 | 1985-10-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Non-reverting salmonella |
US4735801A (en) * | 1982-09-07 | 1988-04-05 | Board Of Trustees Of Leland Stanford Jr. University | Novel non-reverting salmonella live vaccines |
US4837151A (en) * | 1980-05-19 | 1989-06-06 | The Board Of Trustees Of The Leland Stanford Junior University, Stanford University | Live vaccines comprising two mutations and foreign antigen |
DK410783D0 (da) * | 1982-09-16 | 1983-09-09 | Benzon A Salfred | Fremgangsmade til stabilisering af plasmider |
EP0251579A3 (fr) * | 1986-06-24 | 1989-03-22 | Enterovax Research Pty. Ltd. | Système de marquage non-antibiotique |
ES2079348T3 (es) * | 1986-08-05 | 1996-01-16 | Transgene Sa | Procedimiento de estabilizacion de un plasmido contenido en una cepa bacteriana y cepa obtenida. |
JPS6427477A (en) * | 1987-04-01 | 1989-01-30 | Takeda Chemical Industries Ltd | Dna and use thereof |
US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
GB8730037D0 (en) * | 1987-12-23 | 1988-02-03 | Wellcome Found | Vaccines |
AU5432690A (en) * | 1989-03-31 | 1990-11-05 | Washington University | Bordetella vaccines |
ATE190660T1 (de) * | 1990-12-18 | 2000-04-15 | Gen Hospital Corp | Verbesserte impfstoffe |
-
1992
- 1992-02-11 TW TW081100950A patent/TW201794B/zh active
- 1992-04-06 ES ES92105887T patent/ES2160573T3/es not_active Expired - Lifetime
- 1992-04-06 AT AT92105887T patent/ATE202800T1/de not_active IP Right Cessation
- 1992-04-06 PT PT92105887T patent/PT512260E/pt unknown
- 1992-04-06 DE DE69231907T patent/DE69231907T2/de not_active Expired - Fee Related
- 1992-04-06 DK DK92105887T patent/DK0512260T3/da active
- 1992-04-06 EP EP92105887A patent/EP0512260B1/fr not_active Expired - Lifetime
- 1992-04-28 JP JP13437592A patent/JP3320095B2/ja not_active Expired - Fee Related
- 1992-04-30 FI FI921940A patent/FI111013B/fi not_active IP Right Cessation
- 1992-04-30 NO NO19921729A patent/NO314043B1/no unknown
- 1992-04-30 IL IL101751A patent/IL101751A0/xx not_active IP Right Cessation
- 1992-05-01 CA CA002067862A patent/CA2067862C/fr not_active Expired - Fee Related
- 1992-05-01 AU AU15959/92A patent/AU654347B2/en not_active Ceased
- 1992-05-02 KR KR1019920007559A patent/KR100242798B1/ko not_active IP Right Cessation
-
1995
- 1995-01-30 US US08/380,297 patent/US5919663A/en not_active Expired - Fee Related
- 1995-05-24 US US08/448,907 patent/US5961983A/en not_active Expired - Fee Related
-
2001
- 2001-08-31 GR GR20010401346T patent/GR3036487T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0512260A2 (fr) | 1992-11-11 |
DE69231907T2 (de) | 2001-10-18 |
IL101751A0 (en) | 1992-12-30 |
CA2067862A1 (fr) | 1992-11-04 |
NO921729D0 (no) | 1992-04-30 |
TW201794B (fr) | 1993-03-11 |
FI921940A (fi) | 1992-11-04 |
KR100242798B1 (ko) | 2000-02-01 |
EP0512260B1 (fr) | 2001-07-04 |
NO314043B1 (no) | 2003-01-20 |
GR3036487T3 (en) | 2001-11-30 |
ES2160573T3 (es) | 2001-11-16 |
CA2067862C (fr) | 2003-12-30 |
PT512260E (pt) | 2001-12-28 |
NO921729L (no) | 1992-11-04 |
US5919663A (en) | 1999-07-06 |
JPH05192161A (ja) | 1993-08-03 |
DK0512260T3 (da) | 2001-09-17 |
DE69231907D1 (de) | 2001-08-09 |
AU1595992A (en) | 1992-11-05 |
AU654347B2 (en) | 1994-11-03 |
KR920021701A (ko) | 1992-12-18 |
EP0512260A3 (en) | 1993-07-28 |
FI921940A0 (fi) | 1992-04-30 |
JP3320095B2 (ja) | 2002-09-03 |
ATE202800T1 (de) | 2001-07-15 |
US5961983A (en) | 1999-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI111013B (fi) | Stabiileja purA-vektoreita ja niiden käyttö | |
FI110008B (fi) | Menetelmä heikennetyn bakteerin ja sitä sisältävän rokotteen valmistamiseksi | |
Garmory et al. | Salmonella vaccines for use in humans: present and future perspectives | |
US5424065A (en) | Vaccines containing avirulent phop-type microorganisms | |
EP1076566B1 (fr) | Mutants attenues de salmonella expreimant de maniere constitutive l'antigene vi | |
EP0563311B1 (fr) | Vaccins ameliores | |
JP4583607B2 (ja) | 感染症の治療のための弱毒化微生物 | |
JPH11507532A (ja) | 環境に制限される生存能を有する組換え細菌システム | |
JPH04502402A (ja) | 組み換えフラジエリンのワクチン | |
US8475810B2 (en) | Attenuated Salmonella enterica serovar paratyphi a and uses thereof | |
US8137930B2 (en) | Attenuated Salmonella enterica serovar paratyphi A and uses thereof | |
EP0465561A1 (fr) | Microbes avirulents et leurs emplois | |
IL100010A (en) | ALLENOMLAS non-violent strains that include a mutation in the TDC gene and immunogenic preparations that contain the above-mentioned non-violent strains of ALLENOMLAS | |
WO1991018092A1 (fr) | Bacille salmonella typhi tolerant les acides, mutants aro doubles de ce bacille et utilisation de ce bacille comme vaccin administre par voie buccale contre la fievre typhoide | |
PL171476B1 (en) | Method of obtaining attenuated salmonella bacterium |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |