FI110993B - Förfarande för tillverkning av polysakkarid-proteinkonjugat av B-gruppens streptokock typer II och V - Google Patents

Förfarande för tillverkning av polysakkarid-proteinkonjugat av B-gruppens streptokock typer II och V Download PDF

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Publication number
FI110993B
FI110993B FI951412A FI951412A FI110993B FI 110993 B FI110993 B FI 110993B FI 951412 A FI951412 A FI 951412A FI 951412 A FI951412 A FI 951412A FI 110993 B FI110993 B FI 110993B
Authority
FI
Finland
Prior art keywords
type
polysaccharide
gbs
vaccine
protein
Prior art date
Application number
FI951412A
Other languages
English (en)
Finnish (fi)
Other versions
FI951412A0 (sv
FI951412A (sv
Inventor
Harold J Jennings
Dennis L Kasper
Original Assignee
Brigham & Womens Hospital
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26823688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI110993(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US1993/009056 external-priority patent/WO1994006467A1/en
Application filed by Brigham & Womens Hospital, Ca Nat Research Council filed Critical Brigham & Womens Hospital
Publication of FI951412A0 publication Critical patent/FI951412A0/sv
Publication of FI951412A publication Critical patent/FI951412A/sv
Application granted granted Critical
Publication of FI110993B publication Critical patent/FI110993B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Claims (6)

1. Förfarande för tillverkning av en antigen konjugatmolekyl av kapselpolysacka-rid av B-gruppens streptokock typ II eller typ V och protein, kännetecknat av att * 5 (a) kapselpolysackarid av B-gruppens streptokock typ II eller typ V oxideras till- räckligt med perjodat för att bilda en aldehydgrupp i tvä eller flera terminala sial-syrarester anslutna tili polysackaridens stam; (b) den oxiderade kapselpolysackariden av B-gruppens streptokock typ II eller typ V ansluts tili ett protein via reducerande aminering för att ästadkomma en sekundär 10 aminbindning mellan kapselpolysackariden och proteinet.
2. Förfarande enligt patentkrav 1, kännetecknat av att ca 5-50 %, företrädesvis ca 5-35 %, heist ca 5-10 %, av varje polysackarids sialsyrarester oxideras för att bilda aldehydgrupper som förmär anslutas till protein. 15
3. Förfarande enligt patentkrav 2, kännetecknat av att polysackariden är GBS typ II och att ca 7 % av varje polysackarids sialsyrarester oxideras för att bilda aldehydgrupper som förmär anslutas till protein. 20
4. Förfarande enligt patentkrav 1, kännetecknat av att ca 5-50 %, företrädesvis ca 5-25 %, heist ca 5-10 %, av varje polysackarids sialsyrarester binds kovalent tili protein.
5. Förfarande enligt patentkrav 4, kännetecknat av att polysackariden är GBS . · 25 typ II och att ca 5 % av varje polysackarids sialsyrarester binds kovalent till protein.
6. Förfarande enligt patentkrav 1, kännetecknat av att polysackariden är GBS typ V och att ca 25 % av varje polysackarids terminala sialsyrarester binds kovalent till protein. 30 # · * · 4
FI951412A 1992-09-24 1995-03-24 Förfarande för tillverkning av polysakkarid-proteinkonjugat av B-gruppens streptokock typer II och V FI110993B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US94997092A 1992-09-24 1992-09-24
US94997092 1992-09-24
US12555693A 1993-09-23 1993-09-23
US12555693 1993-09-23
US9309056 1993-09-24
PCT/US1993/009056 WO1994006467A1 (en) 1992-09-24 1993-09-24 Group b streptococcus type ii and type v polysaccharide-protein conjugate vaccines

Publications (3)

Publication Number Publication Date
FI951412A0 FI951412A0 (sv) 1995-03-24
FI951412A FI951412A (sv) 1995-05-24
FI110993B true FI110993B (sv) 2003-05-15

Family

ID=26823688

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951412A FI110993B (sv) 1992-09-24 1995-03-24 Förfarande för tillverkning av polysakkarid-proteinkonjugat av B-gruppens streptokock typer II och V

Country Status (16)

Country Link
US (2) US5795580A (sv)
EP (1) EP0667787B1 (sv)
JP (3) JP4163251B2 (sv)
KR (1) KR100293017B1 (sv)
AT (1) ATE203167T1 (sv)
AU (1) AU690525B2 (sv)
CA (1) CA2145397C (sv)
DE (1) DE69330464T2 (sv)
DK (1) DK0667787T3 (sv)
ES (1) ES2160601T3 (sv)
FI (1) FI110993B (sv)
GR (1) GR3036928T3 (sv)
IL (1) IL107103A (sv)
NO (2) NO319569B1 (sv)
NZ (2) NZ248766A (sv)
PT (1) PT667787E (sv)

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DE69940338D1 (de) * 1998-02-05 2009-03-12 Jackson H M Found Military Med Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein-polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeit
US7018637B2 (en) * 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
EP1810978B1 (en) 2000-08-08 2013-02-13 St. Jude Children's Research Hospital Group B streptococcus polypeptides nucleic acids and therapeutic composition and vaccines thereof
SV2003000753A (es) * 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
US20030185858A1 (en) * 2001-08-15 2003-10-02 Birkett Ashley J. Immunogenic HBc chimer particles stabilized with an N-terminal cysteine
US7534442B2 (en) * 2001-08-21 2009-05-19 The Brigham And Women's Hospital, Inc. Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid
AU2003257003A1 (en) * 2002-07-30 2004-02-16 Baxter Healthcare S.A. Chimeric multivalent polysaccharide conjugate vaccines
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GB201101665D0 (en) * 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
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SG11201708242YA (en) * 2015-05-04 2017-11-29 Pfizer Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
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Also Published As

Publication number Publication date
IL107103A0 (en) 1994-08-26
FI951412A0 (sv) 1995-03-24
JP2009132727A (ja) 2009-06-18
CA2145397A1 (en) 1994-03-31
NO951109D0 (no) 1995-03-23
JP4308174B2 (ja) 2009-08-05
KR950703361A (ko) 1995-09-20
JPH08501563A (ja) 1996-02-20
NZ299249A (en) 2000-08-25
JP2005306884A (ja) 2005-11-04
AU5137893A (en) 1994-04-12
NZ248766A (en) 1996-11-26
GR3036928T3 (en) 2002-01-31
AU690525B2 (en) 1998-04-30
NO951109L (no) 1995-05-22
FI951412A (sv) 1995-05-24
DK0667787T3 (da) 2001-10-29
ATE203167T1 (de) 2001-08-15
DE69330464D1 (en) 2001-08-23
NO319569B1 (no) 2005-08-29
US5795580A (en) 1998-08-18
US5993825A (en) 1999-11-30
IL107103A (en) 2001-03-19
PT667787E (pt) 2001-10-31
KR100293017B1 (ko) 2001-09-17
NO951152D0 (no) 1995-03-24
CA2145397C (en) 2007-10-30
ES2160601T3 (es) 2001-11-16
DE69330464T2 (de) 2001-11-08
EP0667787B1 (en) 2001-07-18
JP4163251B2 (ja) 2008-10-08
EP0667787A1 (en) 1995-08-23

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