FI110263B - Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI110263B FI110263B FI952014A FI952014A FI110263B FI 110263 B FI110263 B FI 110263B FI 952014 A FI952014 A FI 952014A FI 952014 A FI952014 A FI 952014A FI 110263 B FI110263 B FI 110263B
- Authority
- FI
- Finland
- Prior art keywords
- oxo
- octahydro
- amino
- carboxylic acid
- phenylpropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96877092A | 1992-10-30 | 1992-10-30 | |
US96877092 | 1992-10-30 | ||
US9309001 | 1993-09-23 | ||
PCT/US1993/009001 WO1994010193A1 (fr) | 1992-10-30 | 1993-09-23 | Nouveaux derives de lactame bicyclique de mercaptoacetylamide utiles, comme inhibiteurs de l'encephalinase et de l'eca |
Publications (3)
Publication Number | Publication Date |
---|---|
FI952014A FI952014A (fi) | 1995-04-27 |
FI952014A0 FI952014A0 (fi) | 1995-04-27 |
FI110263B true FI110263B (fi) | 2002-12-31 |
Family
ID=25514751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI952014A FI110263B (fi) | 1992-10-30 | 1995-04-27 | Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi |
Country Status (21)
Country | Link |
---|---|
US (1) | US5635502A (fr) |
EP (1) | EP0669936B1 (fr) |
JP (1) | JP3420766B2 (fr) |
KR (1) | KR100311166B1 (fr) |
AT (1) | ATE197714T1 (fr) |
AU (1) | AU673857B2 (fr) |
CA (1) | CA2146238C (fr) |
DE (1) | DE69329701T2 (fr) |
DK (1) | DK0669936T3 (fr) |
ES (1) | ES2155852T3 (fr) |
FI (1) | FI110263B (fr) |
GR (1) | GR3035416T3 (fr) |
HU (1) | HUT71243A (fr) |
IL (1) | IL107413A (fr) |
MX (1) | MX9306758A (fr) |
NO (1) | NO951646L (fr) |
NZ (1) | NZ256589A (fr) |
PT (1) | PT669936E (fr) |
TW (1) | TW327172B (fr) |
WO (1) | WO1994010193A1 (fr) |
ZA (1) | ZA937912B (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
JP3563738B2 (ja) * | 1993-06-11 | 2004-09-08 | エーザイ株式会社 | アミノ酸誘導体 |
US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
WO1995021857A1 (fr) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace) |
DK0750631T3 (da) * | 1994-02-14 | 2000-10-23 | Merrell Pharma Inc | Mercaptoacetylamido-1,3,4,5-tetrahydrobenzo[c]azepin-3-ondisulfidderivater som enkephalinase- og ACE-inhibitorer |
AU687984B2 (en) * | 1994-02-14 | 1998-03-05 | Merrell Pharmaceuticals Inc. | Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase |
EP0719779B1 (fr) * | 1994-07-18 | 2003-11-19 | Eisai Co., Ltd. | Derive de thiazolo [3,2-alpha]azepine a substitution |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US6248729B1 (en) | 1998-06-17 | 2001-06-19 | Bristol-Myers Squibb Co. | Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination |
WO2000056724A1 (fr) * | 1999-03-22 | 2000-09-28 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Banques combinatoires d'oxazole et de thiazole |
US7015212B1 (en) | 1999-05-12 | 2006-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Thiazepine inhibitors of HIV-1 integrase |
WO2003068237A1 (fr) | 2002-02-14 | 2003-08-21 | Myriad Genetics, Inc. | Mimetiques de feuillet $g(b) ; compositions et methodes connexes |
FR2984716B1 (fr) | 2011-12-22 | 2013-12-27 | Essilor Int | Dispositif et procede de determination d'au moins un parametre de refraction oculaire objective d'un sujet en fonction d'une pluralite de directions de regard |
US9546174B2 (en) | 2012-11-30 | 2017-01-17 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (IAP) antagonists |
EP3151920A4 (fr) | 2014-06-04 | 2017-12-27 | Sanford-Burnham Medical Research Institute | Utilisation d'un inhibiteur des antagonistes de la protéine d'apoptose (iap) dans une thérapie contre le vih |
US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
US11236103B2 (en) | 2018-07-27 | 2022-02-01 | Biotheryx, Inc. | Bifunctional compounds |
EP4143329A2 (fr) | 2020-04-28 | 2023-03-08 | Anwita Biosciences, Inc. | Polypeptides d'interleukine-2 et protéines de fusion de ceux-ci, ainsi que leurs compositions pharmaceutiques et leurs applications thérapeutiques |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
EP0042100A1 (fr) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Dérivés de la pyrazolopyridazine, intermédiaires et leur procédés de préparation, et médicaments les contenant |
US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
ZA833214B (en) * | 1982-05-12 | 1983-12-28 | Hoffmann La Roche | Bicyclic compounds |
US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
ES8801833A1 (es) * | 1985-04-30 | 1988-02-16 | Lilly Co Eli | Un procedimiento para la preparacion de un compuesto. |
CA1336774C (fr) * | 1986-04-04 | 1995-08-22 | Hiroaki Yanagisawa | Perhydrothiazepine et derives de perhydroazepine, leur preparation et leur utilisation comme agents therapeutiques |
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
ZA874107B (fr) * | 1986-06-13 | 1987-12-09 | ||
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
US5407960A (en) * | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
CA2053340C (fr) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace |
NZ241023A (en) * | 1990-12-21 | 1994-10-26 | Merrell Dow Pharma | Condensed benzazepine derivatives and pharmaceutical compositions |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
WO1993005809A1 (fr) * | 1991-09-16 | 1993-04-01 | Schering Corporation | Compositions pharmaceutiques comprenant des peptides natriuretiques ou des inhibiteurs d'endopeptidase neutres utilises dans le traitement ou la prevention de la proliferation dans la myointima |
GB9204588D0 (en) * | 1992-03-03 | 1992-04-15 | Ferguson Scot Ltd | Containers |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
-
1993
- 1993-09-23 ES ES94914243T patent/ES2155852T3/es not_active Expired - Lifetime
- 1993-09-23 DE DE69329701T patent/DE69329701T2/de not_active Expired - Lifetime
- 1993-09-23 JP JP51105294A patent/JP3420766B2/ja not_active Expired - Fee Related
- 1993-09-23 KR KR1019950701668A patent/KR100311166B1/ko not_active IP Right Cessation
- 1993-09-23 CA CA002146238A patent/CA2146238C/fr not_active Expired - Lifetime
- 1993-09-23 AU AU51362/93A patent/AU673857B2/en not_active Expired
- 1993-09-23 AT AT94914243T patent/ATE197714T1/de active
- 1993-09-23 EP EP94914243A patent/EP0669936B1/fr not_active Expired - Lifetime
- 1993-09-23 DK DK94914243T patent/DK0669936T3/da active
- 1993-09-23 US US08/406,979 patent/US5635502A/en not_active Expired - Lifetime
- 1993-09-23 HU HU9501239A patent/HUT71243A/hu unknown
- 1993-09-23 PT PT94914243T patent/PT669936E/pt unknown
- 1993-09-23 NZ NZ256589A patent/NZ256589A/en not_active IP Right Cessation
- 1993-09-23 WO PCT/US1993/009001 patent/WO1994010193A1/fr active IP Right Grant
- 1993-10-25 ZA ZA937912A patent/ZA937912B/xx unknown
- 1993-10-26 TW TW082108885A patent/TW327172B/zh not_active IP Right Cessation
- 1993-10-27 IL IL10741393A patent/IL107413A/en not_active IP Right Cessation
- 1993-10-29 MX MX9306758A patent/MX9306758A/es unknown
-
1995
- 1995-04-27 FI FI952014A patent/FI110263B/fi not_active IP Right Cessation
- 1995-04-28 NO NO951646A patent/NO951646L/no not_active Application Discontinuation
-
2001
- 2001-02-14 GR GR20010400246T patent/GR3035416T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0669936B1 (fr) | 2000-11-22 |
JP3420766B2 (ja) | 2003-06-30 |
KR950704349A (ko) | 1995-11-20 |
WO1994010193A1 (fr) | 1994-05-11 |
HU9501239D0 (en) | 1995-06-28 |
TW327172B (en) | 1998-02-21 |
NO951646L (no) | 1995-06-23 |
IL107413A0 (en) | 1994-01-25 |
ZA937912B (en) | 1994-06-01 |
US5635502A (en) | 1997-06-03 |
PT669936E (pt) | 2001-04-30 |
FI952014A (fi) | 1995-04-27 |
ES2155852T3 (es) | 2001-06-01 |
CA2146238C (fr) | 2001-03-13 |
NZ256589A (en) | 1996-05-28 |
AU5136293A (en) | 1994-05-24 |
HUT71243A (en) | 1995-11-28 |
NO951646D0 (no) | 1995-04-28 |
CA2146238A1 (fr) | 1994-05-11 |
MX9306758A (es) | 1994-07-29 |
GR3035416T3 (en) | 2001-05-31 |
KR100311166B1 (ko) | 2002-02-28 |
EP0669936A1 (fr) | 1995-09-06 |
FI952014A0 (fi) | 1995-04-27 |
IL107413A (en) | 1999-08-17 |
ATE197714T1 (de) | 2000-12-15 |
DE69329701D1 (de) | 2000-12-28 |
DK0669936T3 (da) | 2001-02-05 |
DE69329701T2 (de) | 2001-05-10 |
JPH08502746A (ja) | 1996-03-26 |
AU673857B2 (en) | 1996-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI110263B (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi | |
FI95255B (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi | |
US5880119A (en) | Mercaptoacetylamino 1,3,4,5-tetrahydro-benzo(C)azepin-2-one disulfide derivatives useful as inhibitors of enkephalinase and ACE | |
KR100271242B1 (ko) | 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 2-치환 인단-2-카르복시알킬 유도체 | |
EP0640617B1 (fr) | Azepino (2,1-a)isoquinoléines substituées | |
US5529996A (en) | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | |
US5637698A (en) | Fused multiple ring lactams | |
IL105729A (en) | History of Azpin Pharmaceutical preparations containing them and processes for their preparation | |
US5635504A (en) | Diazepine containing dual action inhibitors | |
US5629309A (en) | 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE | |
IL112605A (en) | History of the enciplinase and ACE inhibitors of N-N (benzazphenyl tricyclic) acetamide, their preparation and the pharmaceutical preparations containing them | |
NZ278501A (en) | Pyridobenzazepines and analogs with dipeptide structure; medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: AVENTIS INC. Free format text: AVENTIS INC. |
|
PC | Transfer of assignment of patent |
Owner name: AVENTISUB II INC. Free format text: AVENTISUB II INC. |
|
MM | Patent lapsed |