FI109018B - Förfarande för framställning av (S)-alfa-fenyl-2-pyridinetanamin-(S)-malat - Google Patents

Förfarande för framställning av (S)-alfa-fenyl-2-pyridinetanamin-(S)-malat Download PDF

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Publication number
FI109018B
FI109018B FI954645A FI954645A FI109018B FI 109018 B FI109018 B FI 109018B FI 954645 A FI954645 A FI 954645A FI 954645 A FI954645 A FI 954645A FI 109018 B FI109018 B FI 109018B
Authority
FI
Finland
Prior art keywords
phenyl
compound
solution
malate
rats
Prior art date
Application number
FI954645A
Other languages
English (en)
Finnish (fi)
Other versions
FI954645A0 (sv
FI954645A (sv
Inventor
Robert John Murray
Michel Balestra
Donald Mathisen
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1993/000689 external-priority patent/WO1993020052A1/en
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI954645A0 publication Critical patent/FI954645A0/sv
Publication of FI954645A publication Critical patent/FI954645A/sv
Application granted granted Critical
Publication of FI109018B publication Critical patent/FI109018B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI954645A 1993-04-01 1995-09-29 Förfarande för framställning av (S)-alfa-fenyl-2-pyridinetanamin-(S)-malat FI109018B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9300689 1993-04-01
PCT/GB1993/000689 WO1993020052A1 (en) 1992-04-03 1993-04-01 Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders
GB9320273 1993-10-01
GB939320273A GB9320273D0 (en) 1993-04-01 1993-10-01 Compound useful in therapy
GB9400651 1994-03-29
PCT/GB1994/000651 WO1994022831A1 (en) 1993-04-01 1994-03-29 (s)-alpha-phenyl-2-pyridineethanamine (s)-malate and its use as a medicament

Publications (3)

Publication Number Publication Date
FI954645A0 FI954645A0 (sv) 1995-09-29
FI954645A FI954645A (sv) 1995-11-29
FI109018B true FI109018B (sv) 2002-05-15

Family

ID=26302299

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954645A FI109018B (sv) 1993-04-01 1995-09-29 Förfarande för framställning av (S)-alfa-fenyl-2-pyridinetanamin-(S)-malat

Country Status (19)

Country Link
EP (1) EP0691957B1 (sv)
JP (1) JP3023987B2 (sv)
CN (1) CN1047168C (sv)
AT (1) ATE156813T1 (sv)
AU (1) AU682348B2 (sv)
CA (1) CA2159478C (sv)
DE (1) DE69404974T2 (sv)
DK (1) DK0691957T3 (sv)
DZ (1) DZ1765A1 (sv)
ES (1) ES2105672T3 (sv)
FI (1) FI109018B (sv)
GB (1) GB9320273D0 (sv)
GR (1) GR3025081T3 (sv)
IL (1) IL109108A (sv)
MA (1) MA23154A1 (sv)
NO (1) NO304647B1 (sv)
PH (1) PH30950A (sv)
SG (1) SG48204A1 (sv)
WO (1) WO1994022831A1 (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356035B1 (en) * 1988-08-12 1996-03-13 Astra Aktiebolag Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties
ZA942140B (en) * 1993-04-01 1994-10-03 Fisons Corp Salt of (S)-alpha-phenyl-2-pyridineethanamine useful in therapy
SE9901340D0 (sv) 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
SE9901338D0 (sv) * 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
DE10301650A1 (de) * 2003-01-17 2004-07-29 Johannes-Gutenberg-Universität Mainz Medizinisch nützliche 1-Phenyl-2-aminomethylnaphthaline, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung
SG192510A1 (en) 2008-12-24 2013-08-30 Astrazeneca Ab Ethanamine compounds and their use for treating depression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422191A (en) * 1965-01-21 1969-01-14 Synergistics Inc Compositions and methods for tranquilization employing salts of n-morpholine ethanol
EP0356035B1 (en) * 1988-08-12 1996-03-13 Astra Aktiebolag Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties
JP2514855B2 (ja) * 1990-08-08 1996-07-10 キッセイ薬品工業株式会社 光学活性なアラニンアニリド誘導体の酸付加塩
NZ251384A (en) * 1992-04-03 1996-10-28 Fisons Corp (s)-enantiomer of 1-phenyl-2-(2-pyridinyl) ethylamine and medicaments

Also Published As

Publication number Publication date
WO1994022831A1 (en) 1994-10-13
EP0691957A1 (en) 1996-01-17
IL109108A (en) 1999-01-26
CN1098095A (zh) 1995-02-01
GR3025081T3 (en) 1998-01-30
DE69404974D1 (de) 1997-09-18
AU682348B2 (en) 1997-10-02
SG48204A1 (en) 1998-04-17
CN1047168C (zh) 1999-12-08
JPH08508292A (ja) 1996-09-03
DK0691957T3 (da) 1997-10-27
DZ1765A1 (fr) 2002-02-17
ATE156813T1 (de) 1997-08-15
NO304647B1 (no) 1999-01-25
AU6380294A (en) 1994-10-24
CA2159478C (en) 2005-01-25
JP3023987B2 (ja) 2000-03-21
NO953846L (no) 1995-11-21
GB9320273D0 (en) 1993-11-17
DE69404974T2 (de) 1997-12-18
FI954645A0 (sv) 1995-09-29
MA23154A1 (fr) 1994-12-31
NO953846D0 (no) 1995-09-28
FI954645A (sv) 1995-11-29
CA2159478A1 (en) 1994-10-13
IL109108A0 (en) 1994-06-24
ES2105672T3 (es) 1997-10-16
PH30950A (en) 1997-12-23
EP0691957B1 (en) 1997-08-13

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Legal Events

Date Code Title Description
MA Patent expired