DE69404974D1 - (s)-alpha-phenyl-2-pyridinethanamin(s)-malat und seine verwendung als arzneimittel - Google Patents

(s)-alpha-phenyl-2-pyridinethanamin(s)-malat und seine verwendung als arzneimittel

Info

Publication number
DE69404974D1
DE69404974D1 DE69404974T DE69404974T DE69404974D1 DE 69404974 D1 DE69404974 D1 DE 69404974D1 DE 69404974 T DE69404974 T DE 69404974T DE 69404974 T DE69404974 T DE 69404974T DE 69404974 D1 DE69404974 D1 DE 69404974D1
Authority
DE
Germany
Prior art keywords
malate
alpha
phenyl
pyridinethanamine
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69404974T
Other languages
English (en)
Other versions
DE69404974T2 (de
Inventor
Robert Murray
Donald Mathisen
Michel Balestra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1993/000689 external-priority patent/WO1993020052A1/en
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE69404974D1 publication Critical patent/DE69404974D1/de
Publication of DE69404974T2 publication Critical patent/DE69404974T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69404974T 1993-04-01 1994-03-29 (s)-alpha-phenyl-2-pyridinethanamin(s)-malat und seine verwendung als arzneimittel Expired - Lifetime DE69404974T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB1993/000689 WO1993020052A1 (en) 1992-04-03 1993-04-01 Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders
GB939320273A GB9320273D0 (en) 1993-04-01 1993-10-01 Compound useful in therapy
PCT/GB1994/000651 WO1994022831A1 (en) 1993-04-01 1994-03-29 (s)-alpha-phenyl-2-pyridineethanamine (s)-malate and its use as a medicament

Publications (2)

Publication Number Publication Date
DE69404974D1 true DE69404974D1 (de) 1997-09-18
DE69404974T2 DE69404974T2 (de) 1997-12-18

Family

ID=26302299

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69404974T Expired - Lifetime DE69404974T2 (de) 1993-04-01 1994-03-29 (s)-alpha-phenyl-2-pyridinethanamin(s)-malat und seine verwendung als arzneimittel

Country Status (19)

Country Link
EP (1) EP0691957B1 (de)
JP (1) JP3023987B2 (de)
CN (1) CN1047168C (de)
AT (1) ATE156813T1 (de)
AU (1) AU682348B2 (de)
CA (1) CA2159478C (de)
DE (1) DE69404974T2 (de)
DK (1) DK0691957T3 (de)
DZ (1) DZ1765A1 (de)
ES (1) ES2105672T3 (de)
FI (1) FI109018B (de)
GB (1) GB9320273D0 (de)
GR (1) GR3025081T3 (de)
IL (1) IL109108A (de)
MA (1) MA23154A1 (de)
NO (1) NO304647B1 (de)
PH (1) PH30950A (de)
SG (1) SG48204A1 (de)
WO (1) WO1994022831A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648489A1 (de) * 1988-08-12 1995-04-19 Fisons Corporation Arylalkylamide die nervenschützende Eigenschaften besitzen
ZA942140B (en) * 1993-04-01 1994-10-03 Fisons Corp Salt of (S)-alpha-phenyl-2-pyridineethanamine useful in therapy
SE9901340D0 (sv) * 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
SE9901338D0 (sv) * 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
DE10301650A1 (de) * 2003-01-17 2004-07-29 Johannes-Gutenberg-Universität Mainz Medizinisch nützliche 1-Phenyl-2-aminomethylnaphthaline, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung
AU2009330745B2 (en) 2008-12-24 2012-04-05 Astrazeneca Ab Ethanamine compounds and their use for treating depression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422191A (en) * 1965-01-21 1969-01-14 Synergistics Inc Compositions and methods for tranquilization employing salts of n-morpholine ethanol
EP0648489A1 (de) * 1988-08-12 1995-04-19 Fisons Corporation Arylalkylamide die nervenschützende Eigenschaften besitzen
JP2514855B2 (ja) * 1990-08-08 1996-07-10 キッセイ薬品工業株式会社 光学活性なアラニンアニリド誘導体の酸付加塩
AU3897693A (en) * 1992-04-03 1993-11-08 Astra Aktiebolag Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders

Also Published As

Publication number Publication date
NO953846L (no) 1995-11-21
CN1047168C (zh) 1999-12-08
EP0691957A1 (de) 1996-01-17
CN1098095A (zh) 1995-02-01
DK0691957T3 (da) 1997-10-27
WO1994022831A1 (en) 1994-10-13
MA23154A1 (fr) 1994-12-31
PH30950A (en) 1997-12-23
DZ1765A1 (fr) 2002-02-17
AU6380294A (en) 1994-10-24
EP0691957B1 (de) 1997-08-13
ATE156813T1 (de) 1997-08-15
SG48204A1 (en) 1998-04-17
GR3025081T3 (en) 1998-01-30
CA2159478C (en) 2005-01-25
JPH08508292A (ja) 1996-09-03
NO953846D0 (no) 1995-09-28
JP3023987B2 (ja) 2000-03-21
AU682348B2 (en) 1997-10-02
GB9320273D0 (en) 1993-11-17
FI954645A (fi) 1995-11-29
FI109018B (fi) 2002-05-15
FI954645A0 (fi) 1995-09-29
CA2159478A1 (en) 1994-10-13
DE69404974T2 (de) 1997-12-18
NO304647B1 (no) 1999-01-25
IL109108A0 (en) 1994-06-24
IL109108A (en) 1999-01-26
ES2105672T3 (es) 1997-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition