FI107994B - Menetelmä L-DOPA:n etyyliesteriä sisältävän koostumuksen valmistamiseksi - Google Patents

Menetelmä L-DOPA:n etyyliesteriä sisältävän koostumuksen valmistamiseksi Download PDF

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Publication number
FI107994B
FI107994B FI935847A FI935847A FI107994B FI 107994 B FI107994 B FI 107994B FI 935847 A FI935847 A FI 935847A FI 935847 A FI935847 A FI 935847A FI 107994 B FI107994 B FI 107994B
Authority
FI
Finland
Prior art keywords
dopa
ethyl ester
composition
base
solution
Prior art date
Application number
FI935847A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI935847A (fi
FI935847A0 (fi
Inventor
Isaac Milman
Alexander Veinberg
Daphne Atlas
Eldad Melamed
Original Assignee
Teva Pharma
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Yissum Res Dev Co filed Critical Teva Pharma
Publication of FI935847A0 publication Critical patent/FI935847A0/fi
Publication of FI935847A publication Critical patent/FI935847A/fi
Application granted granted Critical
Publication of FI107994B publication Critical patent/FI107994B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI935847A 1992-12-24 1993-12-23 Menetelmä L-DOPA:n etyyliesteriä sisältävän koostumuksen valmistamiseksi FI107994B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/995,847 US5354885A (en) 1992-12-24 1992-12-24 Process for preparing ethyl ester of L-DOPA
US99584792 1992-12-24

Publications (3)

Publication Number Publication Date
FI935847A0 FI935847A0 (fi) 1993-12-23
FI935847A FI935847A (fi) 1994-06-25
FI107994B true FI107994B (fi) 2001-11-15

Family

ID=25542272

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935847A FI107994B (fi) 1992-12-24 1993-12-23 Menetelmä L-DOPA:n etyyliesteriä sisältävän koostumuksen valmistamiseksi

Country Status (21)

Country Link
US (2) US5354885A (es)
EP (2) EP0610595B1 (es)
JP (1) JPH07285860A (es)
CN (1) CN1083262C (es)
AT (2) ATE196081T1 (es)
AU (1) AU684053B2 (es)
CA (1) CA2112160A1 (es)
CY (1) CY2214B1 (es)
DE (2) DE69324466T2 (es)
DK (2) DK0610595T3 (es)
ES (2) ES2132170T3 (es)
FI (1) FI107994B (es)
GR (2) GR3030073T3 (es)
HK (1) HK1012577A1 (es)
HU (1) HU218906B (es)
IL (1) IL108147A (es)
LV (1) LV12766B (es)
NO (1) NO305932B1 (es)
NZ (1) NZ250541A (es)
PT (1) PT867179E (es)
ZA (1) ZA939573B (es)

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SE9203594D0 (sv) * 1992-11-30 1992-11-30 Christer Nystroem Laekemedel i dispersa system
US5840756A (en) * 1995-07-21 1998-11-24 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition of L-DOPA ester
AU7669496A (en) * 1995-11-03 1997-05-22 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
DK0866691T4 (da) * 1995-11-06 2005-06-06 Somerset Pharmaceuticals Inc Medikamenter til sublingual og bukkal administration af selegilin
AU768154B2 (en) * 1996-10-13 2003-12-04 Neuroderm Ltd Treatment of Parkinson's disease
US6166081A (en) * 1997-10-09 2000-12-26 Kushnir; Moshe Methods and apparatus for treatment of Parkinson's disease
US6746688B1 (en) 1996-10-13 2004-06-08 Neuroderm Ltd. Apparatus for the transdermal treatment of Parkinson's disease
IL119417A (en) * 1996-10-13 2003-02-12 Moshe Kushnir Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease
BR9908713A (pt) 1998-03-16 2000-11-21 Somerset Pharmaceuticals Inc Uso de selegilina ou desmetil-selegilina para tratamento de feridas, queimaduras e danos dermatológicos
EP1137626A4 (en) 1998-11-10 2002-07-17 Teva Pharma METHOD FOR PRODUCING L-DOPA ETHYLESTER
EP1135118A1 (en) * 1998-11-10 2001-09-26 Teva Pharmaceutical Industries Ltd. Dispersible compositions containing l-dopa ethyl ester
RU2157196C1 (ru) * 1999-06-17 2000-10-10 Васильев Виталий Николаевич Фармацевтическая композиция в.н. васильева для восстановления функции симпатико-адреналовой системы, способ оценки индивидуальной эффективности этой композиции для терапии пациентов
US6613308B2 (en) * 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6531153B2 (en) * 2001-05-29 2003-03-11 Drugtech Corporation Composition with sustained release of levodopa and carbidopa
IL159813A0 (en) * 2001-07-12 2004-06-20 Teva Pharma Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core
WO2003042136A2 (en) * 2001-11-13 2003-05-22 Teva Pharmaceutical Industries, Ltd. Process for the production of l-dopa ethyl ester
US6696600B2 (en) * 2001-11-13 2004-02-24 Teva Pharmaceutical Industries, Ltd. L-DOPA ethyl ester salts and uses thereof
US7879358B2 (en) 2002-03-20 2011-02-01 Alkermes, Inc. Pulmonary delivery for levodopa
US6930137B2 (en) * 2002-05-31 2005-08-16 Fina Technology, Inc. Method of improving blown film processing performance and physical properties
DE10261807A1 (de) * 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
EP1596808A4 (en) * 2003-02-07 2007-04-04 Yissum Res Dev Co L-DOPA AMID DERIVATIVES AND THEIR USE
WO2004096141A2 (en) * 2003-04-25 2004-11-11 Indevus Pharmaceuticals, Inc. Method for promoting uninterrupted sleep by administration of trospium chloride
KR100525358B1 (ko) * 2003-08-21 2005-11-04 주식회사 이엔에프테크놀로지 카르복실 벤조트리아졸 알킬에스테르의 제조방법
US8815950B2 (en) 2003-08-29 2014-08-26 Janssen Biotech, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
WO2005023185A2 (en) * 2003-08-29 2005-03-17 Transform Pharmaceuticals, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
ATE526988T1 (de) * 2003-10-08 2011-10-15 Mallinckrodt Llc Methylphenidat-lösung und relevante verabreichungs- und herstellungsverfahren
SE0401842D0 (sv) * 2004-07-12 2004-07-12 Dizlin Medical Design Ab Infusion and injection solution of levodopa
ME02508B (me) * 2006-02-17 2017-06-20 Ratiopharm Gmbh Deuterisani derivati kateholamina i medikamenti koji obuhvataju pomenuta jedinjenja
CN101623278B (zh) * 2008-07-09 2013-02-27 北京德众万全药物技术开发有限公司 一种含有左旋多巴和盐酸苄丝肼的药物组合物
JP6982870B2 (ja) 2015-05-06 2021-12-17 シンアジャル コーポレイション 薬物粒子を含有する医薬懸濁液、それらの投与のためのデバイス、およびそれらの使用方法
HUE047531T2 (hu) * 2015-08-27 2020-04-28 Prexton Therapeutics Sa Levodopa indukálta diszkinézia kezelésére alkalmas, agyba bejutni képes kromon oxim-származék
US20190224153A1 (en) 2016-09-29 2019-07-25 Berlirem Gmbh L-dopa derivatives for the treatment of neurological diseases
HUE064010T2 (hu) 2021-02-09 2024-02-28 Biobab R&D S L A 3,4-dihidroxi-fenilalanin (dopa) enantiomerjeinek felhasználása a növények vonzerejének növelésére hasznos rovarok számára és az erre szolgáló eljárás

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ZA716958B (en) * 1970-10-30 1973-01-31 Hoffmann La Roche Phenylalanine amides
US3803120A (en) * 1971-09-28 1974-04-09 Hoffmann La Roche Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
JPS5157813A (en) * 1974-11-14 1976-05-20 Sankyo Co Ll dooba mataha sonojudotaiseizaino seiho
US4035507A (en) * 1975-04-17 1977-07-12 Interx Research Corporation Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease
US4916151A (en) * 1985-12-05 1990-04-10 Merrell Dow Pharmaceuticals Inc. Method of treating parkinson's syndrome
US4771073A (en) * 1985-12-30 1988-09-13 Merck & Co., Inc. Rectally absorbable form of L-dopa
US4663349A (en) * 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa
DE3779500T2 (de) * 1986-06-10 1993-01-21 Chiesi Farma Spa Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.

Also Published As

Publication number Publication date
AU5257793A (en) 1994-07-07
EP0610595A2 (en) 1994-08-17
DE69324466D1 (de) 1999-05-20
HU218906B (hu) 2000-12-28
LV12766B (en) 2002-03-20
NO934768L (no) 1994-06-27
EP0610595B1 (en) 1999-04-14
EP0867179A1 (en) 1998-09-30
ATE196081T1 (de) 2000-09-15
US5354885A (en) 1994-10-11
FI935847A (fi) 1994-06-25
NZ250541A (en) 1995-12-21
IL108147A (en) 1998-09-24
HU9303748D0 (en) 1994-04-28
CY2214B1 (en) 2002-11-08
CN1083262C (zh) 2002-04-24
AU684053B2 (en) 1997-12-04
FI935847A0 (fi) 1993-12-23
LV12766A (lv) 2001-12-20
PT867179E (pt) 2000-12-29
ES2150294T3 (es) 2000-11-16
ATE178793T1 (de) 1999-04-15
HK1012577A1 (en) 1999-08-06
JPH07285860A (ja) 1995-10-31
DE69329400D1 (de) 2000-10-12
DE69324466T2 (de) 1999-11-25
CA2112160A1 (en) 1994-06-25
EP0610595A3 (en) 1994-09-21
DK0610595T3 (da) 1999-10-25
HUT68498A (en) 1995-06-28
GR3034867T3 (en) 2001-02-28
CN1094950A (zh) 1994-11-16
IL108147A0 (en) 1994-04-12
US5525631A (en) 1996-06-11
NO305932B1 (no) 1999-08-23
NO934768D0 (no) 1993-12-22
GR3030073T3 (en) 1999-07-30
DE69329400T2 (de) 2001-01-18
ZA939573B (en) 1994-08-11
EP0867179B1 (en) 2000-09-06
ES2132170T3 (es) 1999-08-16
DK0867179T3 (da) 2000-11-06

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MA Patent expired