FI107737B - Plasmid för att uttrycka en tyrosinhydroxylasgen i hjärnan - Google Patents
Plasmid för att uttrycka en tyrosinhydroxylasgen i hjärnan Download PDFInfo
- Publication number
- FI107737B FI107737B FI992771A FI19992771A FI107737B FI 107737 B FI107737 B FI 107737B FI 992771 A FI992771 A FI 992771A FI 19992771 A FI19992771 A FI 19992771A FI 107737 B FI107737 B FI 107737B
- Authority
- FI
- Finland
- Prior art keywords
- expression
- plasmid
- brain
- disease
- gene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16002—Tyrosine 3-monooxygenase (1.14.16.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20041—Use of virus, viral particle or viral elements as a vector
- C12N2710/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/60—Vectors comprising a special origin of replication system from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
Claims (6)
1. Expressionsplasmid av typ-1 bovin papillomavirus (Bovine Papilloma Virus Type-1, BPV-1), som innehäller
5. El- och E2-gener av papillomavirus för en stabil extrakromosomal replikation, - ett minimal origin-element (MO) av papillomavirusreplikationen, - ett minikxomosomalt upprätthällningselement (MME), - en nukleotidsekvens, som kodar för en tyrosinhydroxylasenzym (ΤΗ).
2. Expressionsplasmid enligt patentkravet 1, som ytterligare innehäller regleringsregioner för att kontrollera expression och transkription.
3. Expressionsplasmid enligt patentkravet 2, i vilken regleringsregionema innehäller promotorer, som leder expression av TH i cellema. 15
4. Expressionsplasmid enligt patentkravet 2, i vilken regleringsregionema innehäller - en uppströms-regleringsregion av BPV-1 (URR) och - en tymidinkinas (Tk) promotor.
5. Användning av en expressionsplasmid enligt nagot av patentkraven 1-4 vid framställning av ett läkemedelspreparat för genterapeutisk behandling av neurala eller nonneurala sjukdomar.
*· • · « ·· ♦ · • *·· 6. Användning enligt patentkravet 5, kännetecknad därav, att sjukdomen är Parkinsons • · *.* 25 sjukdom. ·· φ m · 4 • · * • ♦ · ♦ * · * ^ · • · ··♦ 4 · 4 ··♦ • · ··· • 4 • · #·· ·· 4 4 • ·· 4 4 4
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI992771A FI107737B (sv) | 1999-12-23 | 1999-12-23 | Plasmid för att uttrycka en tyrosinhydroxylasgen i hjärnan |
AU25186/01A AU2518601A (en) | 1999-12-23 | 2000-12-22 | A plasmid for the expression of a therapeutic gene in a tissue |
PCT/FI2000/001140 WO2001048232A1 (en) | 1999-12-23 | 2000-12-22 | A plasmid for the expression of a therapeutic gene in a tissue |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI992771 | 1999-12-23 | ||
FI992771A FI107737B (sv) | 1999-12-23 | 1999-12-23 | Plasmid för att uttrycka en tyrosinhydroxylasgen i hjärnan |
Publications (2)
Publication Number | Publication Date |
---|---|
FI19992771A FI19992771A (sv) | 2001-06-24 |
FI107737B true FI107737B (sv) | 2001-09-28 |
Family
ID=8555804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI992771A FI107737B (sv) | 1999-12-23 | 1999-12-23 | Plasmid för att uttrycka en tyrosinhydroxylasgen i hjärnan |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2518601A (sv) |
FI (1) | FI107737B (sv) |
WO (1) | WO2001048232A1 (sv) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5674703A (en) * | 1992-12-02 | 1997-10-07 | Woo; Savio L. C. | Episomal vector systems and related methods |
EP0870047B1 (en) * | 1995-12-29 | 2008-08-06 | FIT Biotech Oyj Plc | Episomal vector and uses thereof |
AU1275299A (en) * | 1997-10-23 | 1999-05-10 | Uab Research Foundation | Human papillomavirus vectors for the episomal transduction of host cells and method of making same |
FI105105B (sv) * | 1998-02-27 | 2000-06-15 | Finnish Immunotechnology Ltd O | Självreplikerande DNA-vektor för immunisering mot HIV |
-
1999
- 1999-12-23 FI FI992771A patent/FI107737B/sv not_active IP Right Cessation
-
2000
- 2000-12-22 AU AU25186/01A patent/AU2518601A/en not_active Abandoned
- 2000-12-22 WO PCT/FI2000/001140 patent/WO2001048232A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU2518601A (en) | 2001-07-09 |
FI19992771A (sv) | 2001-06-24 |
WO2001048232A1 (en) | 2001-07-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5108797B2 (ja) | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 | |
Klugmann et al. | AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats | |
Wolff et al. | Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. | |
Lemkine et al. | Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor | |
US5851832A (en) | In vitro growth and proliferation of multipotent neural stem cells and their progeny | |
Thompson et al. | Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures | |
NO327597B1 (no) | Modulatorer for vevsregenerering | |
Park et al. | ATF3 negatively regulates adiponectin receptor 1 expression | |
AU777187B2 (en) | Novel mitogenic regulators | |
US5998188A (en) | Mitogen activated protein kinase phosphatase cDNAS and their biologically active expression products | |
EP1107797A2 (en) | Hypoxia regulated genes | |
AU755251B2 (en) | Compositions and methods for sensitizing and inhibiting growth of human tumor cells | |
CN108610409B (zh) | Etv5在制备预防或治疗肥胖症及相关代谢性疾病药物中的应用 | |
FI107737B (sv) | Plasmid för att uttrycka en tyrosinhydroxylasgen i hjärnan | |
Barkats et al. | Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase | |
Ikari et al. | Adenovirus-mediated gene transfer of dopamine D2 receptor cDNA into rat striatum | |
JP2008530029A (ja) | 神経保護剤およびそれらの使用方法 | |
EP2059598B1 (en) | Compositions and methods for modulating ampa receptor-mediated excitotoxicity | |
US8124393B2 (en) | Compositions and methods for inducing or inhibiting activities of selected human cells | |
JP3761152B2 (ja) | ヒトグリア細胞株由来神経栄養因子プロモーター、該プロモーターを含むベクター、および該プロモーターによる化合物のスクリーニング方法 | |
GB2400103A (en) | Cell lines expressing VGSC, Nav1.8 | |
Sui et al. | Neuroprotective roles of HAX-1 in ischemic neuronal injury | |
KR20140030934A (ko) | 퍼옥시레독신 2 융합단백질을 함유하는 뇌 허혈손상 예방 및 치료용 약학 조성물 | |
WO2006123644A1 (ja) | 低酸素ストレス応答に関与するInt6タンパク質、およびその利用 | |
WO1994001135A1 (en) | Method of producing genetically modified astrocytes and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |