FI107256B - Förfarande för framställning av mot tumörer verkande 6-(2-hydroxietylamino) eller 6-[(2-hydroxietyl)aminoalkyl] -5,11-dioxo-5,6-dihydro-11-H-indeno(1, 2-c)isokinoliner - Google Patents
Förfarande för framställning av mot tumörer verkande 6-(2-hydroxietylamino) eller 6-[(2-hydroxietyl)aminoalkyl] -5,11-dioxo-5,6-dihydro-11-H-indeno(1, 2-c)isokinoliner Download PDFInfo
- Publication number
- FI107256B FI107256B FI940895A FI940895A FI107256B FI 107256 B FI107256 B FI 107256B FI 940895 A FI940895 A FI 940895A FI 940895 A FI940895 A FI 940895A FI 107256 B FI107256 B FI 107256B
- Authority
- FI
- Finland
- Prior art keywords
- indeno
- hydroxyethyl
- dioxo
- dihydro
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Claims (6)
1. Förfarande för framställning av ett mot tumörer ver-kande 6-(2-hydroxietylamino eller 2-hydroxietylaminoal-kyl)-5,ll-dioxo-5,6-dihydro-llH-indeno[1,2-c]isokinolin-derivat med den allmänna formeln k. ^N-(CH2)X 0 (I) * eller ett sait därav med en oorganisk eller organisk syra, väri X star för antalet kolatomer frän 0 tili 5 i 25 aminoalkylgruppen bunden vid kväveatomen i position 6 i indenoisokinolin-grundstrukturen, kännetecknat av att a) 11-oxo-llH-indeno[1,2-c]isokumarin med formeln 107256 20 0 (II) I omsättes med N-(hydroxietyl)diamin eller med en N-(hydr-5 oxietyl)alkylendiamin innehällande 1-5 kolatomer i sin alkylkedja i ett lämpligt aprotiskt lösningsmedel, före-trädesvis dimetylformaitiid, och vid förhöjd temperatur, eller j 10 b) l-metoxi-2-(metoxikarbonylfenyl)-l-inden-3-on med ter mein \_^ ^ > v OCH3 coocHg (III) 15 omsättes med N-(hydroxietyl)diamin eller med en N-(hydr oxietyl) alkylendiamin innehällande 1-5 kolatomer i sin alkylkedja vid förhöjd temperatur och i ett lämpligt lösningsmedel, företrädesvis dimetylformamid, eller 20 c) för framställning av en förening med formeln I, väri X är 2-5, omsättes 6-(kloralkyl)-5,ll-dioxo-5,6-dihydro-HH-indeno[1,2-c]isokinolin med formeln 107256 21 \_ N- (CH2) X-C1 O (IV) väri X star för antalet kolatomer frän 2-5 i alkylkedjan, med 2-aminoetanoi vid förhöjd temperatur och i ett lämp-5 ligt lösningsmedel, företrädesvis dimetylformamid, och i närvaro av vattenfritt kaliumkarbonat.
2. Förfarande enligt patentkrav 1, kännetecknat av att man framställer en förening med formeln I, väri n = 2. 10
3. Förfarande enligt patentkrav 1, kännetecknat av att man framställer en förening med formeln I, väri n = 3.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS266991 | 1991-08-29 | ||
| CS912669A CZ281473B6 (cs) | 1991-08-29 | 1991-08-29 | Deriváty 6-/X-(2-hydroxyethyl)aminoalkyl/-5,11 -dioxo-5,6-dihydro-11H-indeno/1,2-c/-isochinolinu a způsob jejich výroby |
| PCT/CS1992/000026 WO1993005023A1 (en) | 1991-08-29 | 1992-08-27 | 6((2-hydroxyethyl)amino alkyl)-5,11-dioxo-5,6-dihydro-11-h-indeno(1,2-c)isoquinoline and their use as antineoplastic agents |
| CS9200026 | 1992-08-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI940895A FI940895A (sv) | 1994-02-25 |
| FI940895A0 FI940895A0 (sv) | 1994-02-25 |
| FI107256B true FI107256B (sv) | 2001-06-29 |
Family
ID=5364459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI940895A FI107256B (sv) | 1991-08-29 | 1994-02-25 | Förfarande för framställning av mot tumörer verkande 6-(2-hydroxietylamino) eller 6-[(2-hydroxietyl)aminoalkyl] -5,11-dioxo-5,6-dihydro-11-H-indeno(1, 2-c)isokinoliner |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0643699B1 (sv) |
| JP (1) | JPH07500581A (sv) |
| AT (1) | ATE144499T1 (sv) |
| AU (1) | AU663729B2 (sv) |
| CA (1) | CA2116680A1 (sv) |
| CZ (1) | CZ281473B6 (sv) |
| DE (1) | DE69214842T2 (sv) |
| DK (1) | DK0643699T3 (sv) |
| FI (1) | FI107256B (sv) |
| HU (1) | HU217551B (sv) |
| NO (1) | NO180194C (sv) |
| PL (1) | PL169572B1 (sv) |
| RU (1) | RU2120939C1 (sv) |
| SK (1) | SK266991A3 (sv) |
| WO (1) | WO1993005023A1 (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| WO2000021537A1 (en) * | 1998-10-14 | 2000-04-20 | Purdue Research Foundation | Novel indenoisoquinolines as antineoplastic agents |
| US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| AU2004258801A1 (en) * | 2003-02-28 | 2005-02-03 | Inotek Pharmaceuticals Corporation | Tetracyclic Benzamide Derivatives and methods of use thereof |
| EP1722797A4 (en) | 2004-02-26 | 2008-03-19 | Inotek Pharmaceuticals Corp | ISOCHINOLINE DERIVATIVES AND METHOD FOR THE APPLICATION THEREOF |
| KR20070116011A (ko) | 2005-02-25 | 2007-12-06 | 이노텍 파마슈티컬스 코포레이션 | 테트라사이클릭 아미노 및 카복사미도 화합물 및 이의 이용방법 |
| JP2009506060A (ja) | 2005-08-24 | 2009-02-12 | イノテック ファーマシューティカルズ コーポレイション | インデノイソキノリノン類縁体及びそれらの使用方法 |
| CA2677046A1 (en) | 2007-02-28 | 2008-09-04 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
| CN102250000A (zh) * | 2010-05-17 | 2011-11-23 | 中国人民解放军第二军医大学 | 茚并喹啉酮类化合物及其制备方法和用途 |
| TWI642658B (zh) * | 2017-11-01 | 2018-12-01 | 國立臺灣師範大學 | 茚並異喹啉衍生物的製備方法 |
-
1991
- 1991-08-29 CZ CS912669A patent/CZ281473B6/cs not_active IP Right Cessation
- 1991-08-29 SK SK2669-91A patent/SK266991A3/sk unknown
-
1992
- 1992-08-27 DE DE69214842T patent/DE69214842T2/de not_active Expired - Fee Related
- 1992-08-27 AU AU25835/92A patent/AU663729B2/en not_active Ceased
- 1992-08-27 JP JP5504800A patent/JPH07500581A/ja active Pending
- 1992-08-27 RU RU94043792A patent/RU2120939C1/ru active
- 1992-08-27 EP EP92920015A patent/EP0643699B1/en not_active Expired - Lifetime
- 1992-08-27 PL PL92302568A patent/PL169572B1/pl unknown
- 1992-08-27 HU HU9400563A patent/HU217551B/hu not_active IP Right Cessation
- 1992-08-27 AT AT92920015T patent/ATE144499T1/de active
- 1992-08-27 CA CA002116680A patent/CA2116680A1/en not_active Abandoned
- 1992-08-27 DK DK92920015.2T patent/DK0643699T3/da active
- 1992-08-27 WO PCT/CS1992/000026 patent/WO1993005023A1/en active IP Right Grant
-
1994
- 1994-02-17 NO NO940542A patent/NO180194C/no not_active IP Right Cessation
- 1994-02-25 FI FI940895A patent/FI107256B/sv active
Also Published As
| Publication number | Publication date |
|---|---|
| FI940895A (sv) | 1994-02-25 |
| CA2116680A1 (en) | 1993-03-18 |
| HUT70396A (en) | 1995-10-30 |
| SK278794B6 (sk) | 1998-03-04 |
| CZ281473B6 (cs) | 1996-10-16 |
| EP0643699B1 (en) | 1996-10-23 |
| HU217551B (hu) | 2000-02-28 |
| JPH07500581A (ja) | 1995-01-19 |
| DE69214842T2 (de) | 1997-02-27 |
| AU2583592A (en) | 1993-04-05 |
| WO1993005023A1 (en) | 1993-03-18 |
| HU9400563D0 (en) | 1994-05-30 |
| DE69214842D1 (de) | 1996-11-28 |
| DK0643699T3 (da) | 1997-04-28 |
| NO180194C (no) | 1997-03-05 |
| NO180194B (no) | 1996-11-25 |
| EP0643699A1 (en) | 1995-03-22 |
| PL169572B1 (pl) | 1996-08-30 |
| CZ266991A3 (en) | 1993-03-17 |
| RU2120939C1 (ru) | 1998-10-27 |
| NO940542L (no) | 1994-02-17 |
| SK266991A3 (en) | 1998-03-04 |
| ATE144499T1 (de) | 1996-11-15 |
| NO940542D0 (no) | 1994-02-17 |
| FI940895A0 (sv) | 1994-02-25 |
| AU663729B2 (en) | 1995-10-19 |
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