FI105817B - Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi Download PDF

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Publication number
FI105817B
FI105817B FI935191A FI935191A FI105817B FI 105817 B FI105817 B FI 105817B FI 935191 A FI935191 A FI 935191A FI 935191 A FI935191 A FI 935191A FI 105817 B FI105817 B FI 105817B
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FI
Finland
Prior art keywords
group
neu
formula
acid
preparation
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Application number
FI935191A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI935191A0 (fi
FI935191A (fi
Inventor
Ursula Habenicht
Paul Thamm
Alessandro Lobbia
Thomas Brumby
Johann Mulzer
Fridtjofy Schroeder
Original Assignee
Schering Ag
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Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI935191A0 publication Critical patent/FI935191A0/fi
Publication of FI935191A publication Critical patent/FI935191A/fi
Application granted granted Critical
Publication of FI105817B publication Critical patent/FI105817B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI935191A 1991-05-24 1993-11-23 Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi FI105817B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4117507 1991-05-24
DE4117507A DE4117507A1 (de) 1991-05-24 1991-05-24 Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
DE9200427 1992-05-22
PCT/DE1992/000427 WO1992020711A2 (fr) 1991-05-24 1992-05-22 Antagonistes de la lhrh et produits intermediaires

Publications (3)

Publication Number Publication Date
FI935191A0 FI935191A0 (fi) 1993-11-23
FI935191A FI935191A (fi) 1993-11-23
FI105817B true FI105817B (fi) 2000-10-13

Family

ID=6432667

Family Applications (2)

Application Number Title Priority Date Filing Date
FI935191A FI105817B (fi) 1991-05-24 1993-11-23 Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi
FI991441A FI114026B (fi) 1991-05-24 1999-06-24 Peptidiyhdisteitä erityisesti LHRH-antagonisteja, joita käytetään hedelmällisyyden kontrollointiin

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI991441A FI114026B (fi) 1991-05-24 1999-06-24 Peptidiyhdisteitä erityisesti LHRH-antagonisteja, joita käytetään hedelmällisyyden kontrollointiin

Country Status (14)

Country Link
US (1) US5527777A (fr)
EP (1) EP0668874B1 (fr)
JP (1) JP3370668B2 (fr)
AT (1) ATE170190T1 (fr)
AU (1) AU667038B2 (fr)
CA (1) CA2109830C (fr)
DE (3) DE4117507A1 (fr)
DK (1) DK0668874T3 (fr)
ES (1) ES2123554T3 (fr)
FI (2) FI105817B (fr)
HU (1) HU219912B (fr)
NO (1) NO311725B1 (fr)
RU (1) RU2124023C1 (fr)
WO (1) WO1992020711A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5916582A (en) * 1996-07-03 1999-06-29 Alza Corporation Aqueous formulations of peptides
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
US6455499B1 (en) 1999-02-23 2002-09-24 Indiana University Foundation Methods for treating disorders associated with LHRH activity
DE19911771B4 (de) * 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
GB201009603D0 (en) * 2010-06-08 2010-07-21 Cambridge Entpr Ltd Anti-inflammatory agent
AR122446A1 (es) * 2020-04-29 2022-09-14 Medimmune Llc Composiciones y métodos para suministrar agentes farmacéuticamente activos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667014A (en) * 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors

Also Published As

Publication number Publication date
HU9303324D0 (en) 1994-03-28
FI935191A0 (fi) 1993-11-23
JPH06508115A (ja) 1994-09-14
US5527777A (en) 1996-06-18
CA2109830A1 (fr) 1992-11-26
JP3370668B2 (ja) 2003-01-27
ATE170190T1 (de) 1998-09-15
CA2109830C (fr) 2003-04-08
EP0668874B1 (fr) 1998-08-26
EP0668874A1 (fr) 1995-08-30
NO934237D0 (no) 1993-11-23
FI991441A0 (fi) 1999-06-24
DE59209476D1 (de) 1998-10-01
AU1887992A (en) 1992-12-30
DE4291426D2 (de) 1994-02-17
WO1992020711A3 (fr) 1993-03-18
ES2123554T3 (es) 1999-01-16
RU2124023C1 (ru) 1998-12-27
WO1992020711A2 (fr) 1992-11-26
HU219912B (hu) 2001-09-28
FI935191A (fi) 1993-11-23
HUT65732A (en) 1994-07-28
NO934237L (no) 1993-11-23
AU667038B2 (en) 1996-03-07
DK0668874T3 (da) 1999-05-25
FI114026B (fi) 2004-07-30
FI991441A (fi) 1999-06-24
NO311725B1 (no) 2002-01-14
DE4117507A1 (de) 1992-11-26

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