FI105817B - Förfarande för framställning av terapeutiskt användbara peptidföreningar - Google Patents
Förfarande för framställning av terapeutiskt användbara peptidföreningar Download PDFInfo
- Publication number
- FI105817B FI105817B FI935191A FI935191A FI105817B FI 105817 B FI105817 B FI 105817B FI 935191 A FI935191 A FI 935191A FI 935191 A FI935191 A FI 935191A FI 105817 B FI105817 B FI 105817B
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- Finland
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- neu
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (7)
1 I 15 kännetecknat av att peptidisyntesen utförs genom användning en fastfas- eller lösningsteknik pä ett i och för sig känt sätt.
1. Förfarande för framställning av terapeutiskt an-vändbara peptidföreningar med formeln 5 X-Xi-X2-X3_L-Ser-L-Tyr-X6-L-Leu-X8-L-Pro-Xio (I) 1234 56 78 9 10 väri
10 X är en naftoyl-, naftylacetyl-, naftylpropionyl- eller bensoylgrupp eller en acylgrupp med 1-7 kolatomer, Xi är D-(1)-Nai, D-(2)-Nal, D-Phe, D-(4-Y)-Phe, D-(3)-Qal eller en direkt bindning, varvid Y är en F-, Br- eller Cl-grupp,
15 X2 är D-Phe, D-(4-Y)-Phe eller en direkt bindning, varvid Y är ovan definierad, X3 är D-Trp, D-Phe, D-(4-Y)-Phe, D-(3)-Pal, D-(2)-Nai eller en direkt bindning, varvid Y betecknar detsairana som Xi ovan, 20 Χβ är D-Cit, D-Hci, D-Orn, D-Lys eller D-Neu, X8 är L-Orn, L-Arg, L-Lys eller L-Neu, varvid ät-minstone en av rester Χβ och X8 är Neu, och X10 är D-Ala-NH2, Gly-NH2, azaglysin, -NHEt eller -NH(CO)NH2, varvid Neu är en grupp med formeln IX eller IV 25 _/2|\ |H2 fH2 W CH«S /CH2 ICH J r . N ΠΧ) (IV) »o cch.j , il jU i 2 nl I 0 VV I o H väri Ζχ är en grupp 40 105817 XCH X / ! ' / ' \ \ \ 5 /S ' /”« eller en direkt bindning, n är 1 - 8, ni är 3 - 6 och 10 W är en rest O* eller On
2. Förfarande enligt patentkrav 1, kanne-20 tecknat av att Neu är en grupp raed formeln X: 0 / \ |H2 fH2 c\ /CH^ - 25 Γ 1X1 lCH,l , '/y I 0 H väri ni är 3 - 6. . 30
3. Förfarande enligt patentkrav 2, kanne- ·’ tecknat av att Neu är en rest med formeln 41 O / fH2 fH2 CV /CH* } YY I o H 10
4. Förfarande enligt patentkrav 3, kännetecknat av att Neu är eller Xs-
5. Förfarande enligt patentkrav 1, kännetecknat av att Neu är en grupp med for-meln XIII: 15 „_ O J (XIII) 20 f yV H
6. Förfarande enligt nägot av patentkraven 1-5, 25 kännetecknat av att X är en etanoylgrupp, Xi är D-Nal, X2 är D-Cpa, * X3 är D-Pal och
30 Xio är D-Ala-NH2.
7. Förfarande enligt patentkrav 1-4, kännetecknat av att peptiden Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Ahx(Mor)-Pro-D-AlaNH2 framställs.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4117507 | 1991-05-24 | ||
| DE4117507A DE4117507A1 (de) | 1991-05-24 | 1991-05-24 | Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten |
| DE9200427 | 1992-05-22 | ||
| PCT/DE1992/000427 WO1992020711A2 (de) | 1991-05-24 | 1992-05-22 | Lhrh-antagonisten und zwischenprodukte |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI935191A0 FI935191A0 (fi) | 1993-11-23 |
| FI935191A FI935191A (fi) | 1993-11-23 |
| FI105817B true FI105817B (sv) | 2000-10-13 |
Family
ID=6432667
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI935191A FI105817B (sv) | 1991-05-24 | 1993-11-23 | Förfarande för framställning av terapeutiskt användbara peptidföreningar |
| FI991441A FI114026B (sv) | 1991-05-24 | 1999-06-24 | Peptidföreningar, speciellt LHRH-antagonister, som används vid fertilitetskontroll |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI991441A FI114026B (sv) | 1991-05-24 | 1999-06-24 | Peptidföreningar, speciellt LHRH-antagonister, som används vid fertilitetskontroll |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5527777A (sv) |
| EP (1) | EP0668874B1 (sv) |
| JP (1) | JP3370668B2 (sv) |
| AT (1) | ATE170190T1 (sv) |
| AU (1) | AU667038B2 (sv) |
| CA (1) | CA2109830C (sv) |
| DE (3) | DE4117507A1 (sv) |
| DK (1) | DK0668874T3 (sv) |
| ES (1) | ES2123554T3 (sv) |
| FI (2) | FI105817B (sv) |
| HU (1) | HU219912B (sv) |
| NO (1) | NO311725B1 (sv) |
| RU (1) | RU2124023C1 (sv) |
| WO (1) | WO1992020711A2 (sv) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| US5932547A (en) * | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| US5981489A (en) * | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
| US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
| DE19911771B4 (de) * | 1999-03-17 | 2006-03-30 | Zentaris Gmbh | LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung |
| GB201009603D0 (en) * | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| AR122446A1 (es) * | 2020-04-29 | 2022-09-14 | Medimmune Llc | Composiciones y métodos para suministrar agentes farmacéuticamente activos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4667014A (en) * | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
-
1991
- 1991-05-24 DE DE4117507A patent/DE4117507A1/de not_active Withdrawn
-
1992
- 1992-05-22 CA CA002109830A patent/CA2109830C/en not_active Expired - Fee Related
- 1992-05-22 WO PCT/DE1992/000427 patent/WO1992020711A2/de active IP Right Grant
- 1992-05-22 RU RU93058365A patent/RU2124023C1/ru not_active IP Right Cessation
- 1992-05-22 US US08/142,429 patent/US5527777A/en not_active Expired - Fee Related
- 1992-05-22 AT AT92910746T patent/ATE170190T1/de not_active IP Right Cessation
- 1992-05-22 DK DK92910746T patent/DK0668874T3/da active
- 1992-05-22 EP EP92910746A patent/EP0668874B1/de not_active Expired - Lifetime
- 1992-05-22 DE DEDE9200427T patent/DE4291426D2/de not_active Expired - Lifetime
- 1992-05-22 JP JP50975692A patent/JP3370668B2/ja not_active Expired - Fee Related
- 1992-05-22 ES ES92910746T patent/ES2123554T3/es not_active Expired - Lifetime
- 1992-05-22 AU AU18879/92A patent/AU667038B2/en not_active Ceased
- 1992-05-22 DE DE59209476T patent/DE59209476D1/de not_active Expired - Lifetime
- 1992-05-22 HU HU9303324A patent/HU219912B/hu not_active IP Right Cessation
-
1993
- 1993-11-23 FI FI935191A patent/FI105817B/sv not_active IP Right Cessation
- 1993-11-23 NO NO19934237A patent/NO311725B1/no unknown
-
1999
- 1999-06-24 FI FI991441A patent/FI114026B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9303324D0 (en) | 1994-03-28 |
| FI935191A0 (fi) | 1993-11-23 |
| JPH06508115A (ja) | 1994-09-14 |
| US5527777A (en) | 1996-06-18 |
| CA2109830A1 (en) | 1992-11-26 |
| JP3370668B2 (ja) | 2003-01-27 |
| ATE170190T1 (de) | 1998-09-15 |
| CA2109830C (en) | 2003-04-08 |
| EP0668874B1 (de) | 1998-08-26 |
| EP0668874A1 (de) | 1995-08-30 |
| NO934237D0 (no) | 1993-11-23 |
| FI991441A0 (sv) | 1999-06-24 |
| DE59209476D1 (de) | 1998-10-01 |
| AU1887992A (en) | 1992-12-30 |
| DE4291426D2 (de) | 1994-02-17 |
| WO1992020711A3 (de) | 1993-03-18 |
| ES2123554T3 (es) | 1999-01-16 |
| RU2124023C1 (ru) | 1998-12-27 |
| WO1992020711A2 (de) | 1992-11-26 |
| HU219912B (hu) | 2001-09-28 |
| FI935191A (fi) | 1993-11-23 |
| HUT65732A (en) | 1994-07-28 |
| NO934237L (no) | 1993-11-23 |
| AU667038B2 (en) | 1996-03-07 |
| DK0668874T3 (da) | 1999-05-25 |
| FI114026B (sv) | 2004-07-30 |
| FI991441A (sv) | 1999-06-24 |
| NO311725B1 (no) | 2002-01-14 |
| DE4117507A1 (de) | 1992-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |