FI105775B - Menetelmä uusien terapeuttisesti käyttökelpoisten somatostatiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten somatostatiinijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI105775B
FI105775B FI920340A FI920340A FI105775B FI 105775 B FI105775 B FI 105775B FI 920340 A FI920340 A FI 920340A FI 920340 A FI920340 A FI 920340A FI 105775 B FI105775 B FI 105775B
Authority
FI
Finland
Prior art keywords
group
tyr
trp
cys
lys
Prior art date
Application number
FI920340A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI920340A (fi
FI920340A0 (fi
Inventor
Istvan Teplan
Judit Horvath
Aniko Horvath
Gyoergy Keri
Imre Mezo
Janos Seprodi
Balazs Szoke
Zsolt Vadasz
Agnes Balogh
Orsolya Csuka
Gyoengyi Boekoenyi
Miklos Idei
Original Assignee
Biosignal Kutato Fejlesztoe Kf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosignal Kutato Fejlesztoe Kf filed Critical Biosignal Kutato Fejlesztoe Kf
Publication of FI920340A0 publication Critical patent/FI920340A0/fi
Publication of FI920340A publication Critical patent/FI920340A/fi
Application granted granted Critical
Publication of FI105775B publication Critical patent/FI105775B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FI920340A 1991-01-25 1992-01-24 Menetelmä uusien terapeuttisesti käyttökelpoisten somatostatiinijohdannaisten valmistamiseksi FI105775B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU91272A HU207104B (en) 1991-01-25 1991-01-25 Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
HU27291 1991-01-25

Publications (3)

Publication Number Publication Date
FI920340A0 FI920340A0 (fi) 1992-01-24
FI920340A FI920340A (fi) 1992-07-26
FI105775B true FI105775B (fi) 2000-10-13

Family

ID=10948847

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920340A FI105775B (fi) 1991-01-25 1992-01-24 Menetelmä uusien terapeuttisesti käyttökelpoisten somatostatiinijohdannaisten valmistamiseksi

Country Status (10)

Country Link
US (1) US5480870A (de)
EP (1) EP0505680B1 (de)
JP (1) JP2514518B2 (de)
KR (1) KR920014828A (de)
AT (1) ATE121753T1 (de)
CA (1) CA2060034C (de)
DE (1) DE69202182T2 (de)
ES (1) ES2074294T3 (de)
FI (1) FI105775B (de)
HU (1) HU207104B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
IT1277391B1 (it) * 1995-07-28 1997-11-10 Romano Deghenghi Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
AU3215597A (en) 1996-08-30 1998-03-19 Biomeasure Incorporated Method of inhibiting fibrosis with a somatostatin agonist
EP0981364B1 (de) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Methoden und zusammensetzungen zur behandlung der hyperlipidämie
US7034003B1 (en) 1997-05-13 2006-04-25 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Somatostatin and somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
HU226567B1 (en) * 1998-04-27 2009-04-28 Biostatin Gyogyszerkutato Fejl Use of phenylhydrazon derivates for the preparation of medicaments for the inhibition of neurogenic and non-neurogenic inflammations and for the alleviation of pain
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
WO2000011031A1 (de) * 1998-08-20 2000-03-02 Orpegen Pharma Gesellschaft Für Biotechnologische Forschung, Entwicklung Und Produktion Mbh Verfahren zur herstellung von biostatin (tt-232 triacetat) und seine analoga
RU2263680C2 (ru) * 1999-06-04 2005-11-10 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик Сас Агонисты рецепторов нейромедина в и соматостатина
MXPA01013127A (es) * 1999-06-25 2002-11-04 Sod Conseils Rech Applic Agonistas de somatostatina.
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists
CA2449634C (en) 2001-06-08 2011-08-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Somatostatin-dopamine chimeric analogs
US6987167B2 (en) * 2002-05-22 2006-01-17 Wockhardt Limited Process for production of the somatostatin analog, octreotide
SG173223A1 (en) 2003-04-22 2011-08-29 Ipsen Pharma Sas Peptide vectors
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
PT2064228E (pt) 2006-11-10 2012-12-10 Cara Therapeutics Inc Amidas peptídicas sintéticas
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
KR101731655B1 (ko) 2008-06-12 2017-05-11 입센 바이오이노베이션 리미티드 암 억제 방법
EP3590956A1 (de) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Unterdrückung von neuroendokrinen erkrankungen
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
JP2568228B2 (ja) * 1987-02-03 1996-12-25 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ソマトスタチンアナログ
JP2809403B2 (ja) * 1987-07-07 1998-10-08 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ソマトスタチンアナログ化合物
CA2012115C (en) * 1989-03-15 2001-07-03 Biomeasure, Inc. Iodinated somatostatins
DK0457888T3 (da) * 1989-12-08 1996-08-12 Univ Tulane Octapeptidanaloger af somatostatin med threonin i 6-stillingen

Also Published As

Publication number Publication date
CA2060034C (en) 2002-10-29
ATE121753T1 (de) 1995-05-15
ES2074294T3 (es) 1995-09-01
HU910272D0 (en) 1991-08-28
HUT60752A (en) 1992-10-28
HU207104B (en) 1993-03-01
DE69202182T2 (de) 1995-08-31
DE69202182D1 (de) 1995-06-01
US5480870A (en) 1996-01-02
JP2514518B2 (ja) 1996-07-10
EP0505680A1 (de) 1992-09-30
FI920340A (fi) 1992-07-26
KR920014828A (ko) 1992-08-25
FI920340A0 (fi) 1992-01-24
JPH05163299A (ja) 1993-06-29
CA2060034A1 (en) 1992-07-26
EP0505680B1 (de) 1995-04-26

Similar Documents

Publication Publication Date Title
FI105775B (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten somatostatiinijohdannaisten valmistamiseksi
US7084244B2 (en) Conformationally constrained backbone cyclized peptide analogs
EP0804468B1 (de) Verfahren zur synthese eines an der omega-position funktionalisierten aminosäure-derivats
Sasaki et al. Solid-phase synthesis and biological properties of. psi.[CH2NH] pseudopeptide analogs of a highly potent somatostatin octapeptide
JP6007187B2 (ja) デガレリクスおよびその中間体を製造する方法
US4758550A (en) Calcitonin derivatives
JPH0161120B2 (de)
US20060281685A1 (en) Methods of treatment using novel lhrh antagonists having improved solubility properties
IT9020273A1 (it) Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
JP2010265271A (ja) ソマトスタチンベクター
Besser et al. Synthesis and characterization of octapeptide somatostatin analogues with backbone cyclization: comparison of different strategies, biological activities and enzymatic stabilities
EP0842193B1 (de) Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität
Li et al. Synthesis, conformational analysis and bioactivity of Lan‐7, a lanthionine analog of TT‐232
Procházka et al. Synthesis and biological properties of vasopressin analogues containing 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid
UCHIYAMA et al. Studies on Secretin. I. Synthesis of Completely Protected Secretin
AU724386B2 (en) Conformationally constrained backbone cyclized peptide analogs
GB2118190A (en) Peptides with sauvagine-like activity
GB2156822A (en) Biologically active tridecapeptides