FI105023B - Förfarande för framställning av terapeutiskt användbara difenyl-4-perhydroisoindolderivat - Google Patents
Förfarande för framställning av terapeutiskt användbara difenyl-4-perhydroisoindolderivat Download PDFInfo
- Publication number
- FI105023B FI105023B FI944729A FI944729A FI105023B FI 105023 B FI105023 B FI 105023B FI 944729 A FI944729 A FI 944729A FI 944729 A FI944729 A FI 944729A FI 105023 B FI105023 B FI 105023B
- Authority
- FI
- Finland
- Prior art keywords
- diphenyl
- methoxyphenyl
- radical
- kpa
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (7)
1. Pörfarande för framställning av terapeutiskt användbara difenyl-4-perhydroisoindolderivat med formeln 5 (I) och salter därav: « (I) N —C —CH —R,
10 Rr-k I r2 R3 R4 väri - symbolen R! är en fenylradikal, som eventuellt är sub-15 stituerad med hydroxi-, alkoxi- eller dialkylaminoradi- kaler, eller R1 är en indolylradikal, som kan vara sub-stituerad med halogen eller en alkyl- eller alkoxiradikal, eller R1 är naftyl, tienyl, indenyl eller bensotienyl, - symbolen R2 är en väteatom eller en hydroxi-, alkyl- 20 eller aminoradikal, - symbolen R3 är en fenylradikal, som eventuellt i 2-posi-tionen är substituerad med en alkyl- eller alkyloxiradikal med 1 eller 2 kolatomer, och - symbolen R4 är en fluoratom eller en hydroxiradikal, : 25 och symbolen Rs är en väteatom eller - symbolerna R4 och R5 är hydroxiradikaler, eller - symbolen R4 bildar tillsammans med R5 är en bindning, varvid ovannämnda alkylradikaler är rakkedjade eller förgrenade och innehäller 1-4 kolatomer, som racemiska 30 blandningar, stereoisomeriska former med strukturen: (Ia) TC- I N — C — CH — R, R3 R4 105023 64 i sinä (R) - eller (S)-former i kedjan -CHR^, eller i form av en blandning av flera av dessa former, kanne -tecknat av att (A) en syra med formeln II eller ett reaktivt derivat därav 5 Rj-CH-COOH (II) k väri R3 och R2 är säsom ovan definierats, omsätts med ett 10 isoindolderivat med den allmänna formeln:
15 NH (III) r5— r37 r4 väri symbolerna R3, R4 och Rs är säsom ovan definierats, ~ 20 varefter (Al) den erhällna föreningen, väri R4 är en hydroxiradikal och R5 är en väteatom, eventuellt omvandlas tili en förening, väri R4 är en fluoratom och Rs är en väteatom eller väri R4 och R5 tillsammans bildar en bindning, eller (B) för framställning av ett sädant perhydroisoin-: 25 dolderivat enligt patentkrav l, väri Rs är annat än en hydroxiradikal, omsätts en organometallförening med den allmänna formeln: R3-M 30 väri R3 är säsom ovan definierats, och M är litium, en radikal MgX eller CeX2, väri X är en halogenatom, med ett perhydroisoindolonderivat med den allmänna formeln 35 • · ••=3 : ~i « 105023 ob , 5 __^N —C—CH —R1 0 väri R* och R2 är säsom ovan definierats, varefter (Bl) den 10 erhällna alkoholen eventuellt omvandlas till ett per-hydroisoindolderivat, väri R4 är en fluoratom och Rs är en väteatom, eller till ett perhydroisoindolderivat, väri R4 och R5 tillsammans bildar en bindning, varefter (C) eventuellt separeras isomererna, och/eller (D) omvandlas den 15 erhällna föreningen till ett salt.
2. Förfarande enligt patentkrav 1, k ä n n e -tecknat av att man framställer 7,7-difenyl-4-(2-metoxifenyl)-2-[2-(2-metoxifenyl)propionyl]-4-perhydroiso-indolol. 20
3. Förfarande enligt patentkrav 1, k ä n n e - tecknat av att man framställer 7,7-difenyl-4-(2-metoxifenyl)-2- [2- (2-metoxifenyl)propionyl]perhydroisoin-dol-4,5-diol.
4. Förfarande enligt patentkrav 1, k ä n n e - : 25 tecknat av att man framställer 7,7-difenyl-4-(2- metoxifenyl)-2-[2-(2-hydroxifenyl) acetyl]-4-perhydroisoin-dolol.
5. Förfarande enligt patentkrav 1, k ä n n e -tecknat av att man framställer 7,7-difenyl-4 -(2 - 30 metoxifenyl)-2-(3-indolylacetyl)perhydroisoindol-4,5-diol.
, 6. Förfarande enligt patentkrav 1, k ä n n e - tecknat av att man framställer 7,7-difenyl-4-(2-metoxifenyl)-2-[(2-metoxifenyl)acetyl]-4-perhydroisoin-dolol. 35
7. Förfarande enligt patentkrav l, kanne- tecknat av att man framställer 7,7-difenyl-4-(2-metoxifenyl)-2-[2-(2-hydroxifenyl)propionyl]-4-perhydro-isoindolol.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9204390 | 1992-04-10 | ||
FR929204390A FR2689888B1 (fr) | 1992-04-10 | 1992-04-10 | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR9300352 | 1993-01-15 | ||
PCT/FR1993/000352 WO1993021155A1 (fr) | 1992-04-10 | 1993-04-08 | Derives de perhydroisoindole comme antagonistes de la substance p |
Publications (3)
Publication Number | Publication Date |
---|---|
FI944729A FI944729A (sv) | 1994-10-07 |
FI944729A0 FI944729A0 (sv) | 1994-10-07 |
FI105023B true FI105023B (sv) | 2000-05-31 |
Family
ID=9428707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI944729A FI105023B (sv) | 1992-04-10 | 1994-10-07 | Förfarande för framställning av terapeutiskt användbara difenyl-4-perhydroisoindolderivat |
Country Status (24)
Country | Link |
---|---|
US (1) | US5484804A (sv) |
EP (1) | EP0635003B1 (sv) |
JP (1) | JP3205557B2 (sv) |
KR (1) | KR950700880A (sv) |
AT (1) | ATE167472T1 (sv) |
AU (1) | AU667214B2 (sv) |
CA (1) | CA2133840A1 (sv) |
CZ (1) | CZ284213B6 (sv) |
DE (1) | DE69319235T2 (sv) |
DK (1) | DK0635003T3 (sv) |
ES (1) | ES2118232T3 (sv) |
FI (1) | FI105023B (sv) |
FR (1) | FR2689888B1 (sv) |
HU (1) | HUT71354A (sv) |
IL (1) | IL105255A (sv) |
MX (1) | MX9301986A (sv) |
NO (1) | NO300417B1 (sv) |
NZ (1) | NZ251730A (sv) |
PL (1) | PL172754B1 (sv) |
RU (1) | RU2127260C1 (sv) |
SK (1) | SK279032B6 (sv) |
TW (1) | TW234119B (sv) |
WO (1) | WO1993021155A1 (sv) |
ZA (1) | ZA932527B (sv) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2700472B1 (fr) | 1993-01-19 | 1995-02-17 | Rhone Poulenc Rorer Sa | Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2. |
FR2703679B1 (fr) * | 1993-04-05 | 1995-06-23 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
TW365603B (en) * | 1993-07-30 | 1999-08-01 | Rhone Poulenc Rorer Sa | Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them |
FR2710913B1 (fr) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2709752B1 (fr) * | 1993-07-30 | 1995-10-06 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2710842B1 (fr) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | Nouvelle application thérapeutique de dérivés de perhydroisoindole. |
FR2725900B1 (fr) * | 1994-10-21 | 1997-07-18 | Sanofi Sa | Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice |
FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5789433A (en) * | 1995-01-17 | 1998-08-04 | Quadra Logic Technologies, Inc. | Green porphyrins as immunomodulators |
US6107325A (en) * | 1995-01-17 | 2000-08-22 | Qlt Phototherapeutics, Inc. | Green porphyrins as immunomodulators |
US6096776A (en) * | 1995-01-17 | 2000-08-01 | Qlt Phototherapeutics, Inc. | Green porphyrins as immunomodulators |
FR2737495B1 (fr) * | 1995-08-02 | 1997-08-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
AU744261B2 (en) * | 1997-04-24 | 2002-02-21 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating eating disorders |
AU738047B2 (en) * | 1997-08-04 | 2001-09-06 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating mania |
GB9716463D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
AU737019B2 (en) * | 1997-08-04 | 2001-08-09 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating aggressive behaviour disorders |
GB9716457D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
GB9816897D0 (en) * | 1998-08-04 | 1998-09-30 | Merck Sharp & Dohme | Therapeutic use |
US7101547B1 (en) | 1999-01-22 | 2006-09-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies |
ES2304984T3 (es) | 1999-11-03 | 2008-11-01 | Amr Technology, Inc. | Tetra-hidroisoquinolinas de sustitucion arilica y heteroarilica y su utilizacion para bloquear la recaptacion de norepinefrina, dopamina y serotonina. |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
JP5007226B2 (ja) | 2004-07-15 | 2012-08-22 | エーエムアール テクノロジー インコーポレイテッド | アリールおよびヘテロアリール置換テトラヒドロイソキノリンならびにノルエピネフリン、ドーパミン、およびセロトニンの再取り込みを遮断するためのその利用方法 |
WO2006123182A2 (en) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Cyclohexyl sulphones for treatment of cancer |
KR101589551B1 (ko) | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
CA2624030A1 (en) | 2005-09-29 | 2007-04-12 | Tianying Jian | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
EP2946778A1 (en) | 2006-09-22 | 2015-11-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP2109608B1 (en) | 2007-01-10 | 2011-03-23 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
EP3103791B1 (en) | 2007-06-27 | 2018-01-31 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
WO2009111354A2 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
CN102458123A (zh) | 2009-05-12 | 2012-05-16 | 阿尔巴尼分子研究公司 | 芳基、杂芳基和杂环取代的四氢异喹啉及其用途 |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
KR101830447B1 (ko) | 2009-05-12 | 2018-02-20 | 알바니 몰레큘라 리써치, 인크. | 7-([1,2,4]트리아졸로[1,5-α]피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도 |
CN104945382B (zh) | 2009-10-14 | 2020-02-07 | 默沙东公司 | 提高p53活性的取代的哌啶和其用途 |
US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
JP6043285B2 (ja) | 2010-08-02 | 2016-12-14 | サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
CN108676800B (zh) | 2010-08-17 | 2022-11-11 | 瑟纳治疗公司 | 使用短干扰核酸(siNA)的乙型肝炎病毒(HBV)基因表达的RNA干扰介导的抑制 |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
ES2663009T3 (es) | 2010-10-29 | 2018-04-10 | Sirna Therapeutics, Inc. | Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic) |
EP2654748B1 (en) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
CN103732592A (zh) | 2011-04-21 | 2014-04-16 | 默沙东公司 | 胰岛素样生长因子-1受体抑制剂 |
WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
EP3358013B1 (en) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
CN105050598B (zh) | 2012-09-28 | 2018-04-27 | 默沙东公司 | 作为erk抑制剂的新型化合物 |
CA2892361A1 (en) | 2012-11-28 | 2014-06-05 | Merck Sharp & Dohme Corp. | Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels |
AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3525785A4 (en) | 2016-10-12 | 2020-03-25 | Merck Sharp & Dohme Corp. | KDM5 INHIBITORS |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR514273A (fr) * | 1920-04-23 | 1921-03-07 | Georges Loutz | Bougie d'allumage électrique pour moteurs à explosions |
US4042707A (en) * | 1976-02-19 | 1977-08-16 | E. I. Du Pont De Nemours And Company | 3α-Arylhydroisoindoles |
FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2676442B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2689889B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, et leur preparation. |
-
1992
- 1992-04-10 FR FR929204390A patent/FR2689888B1/fr not_active Expired - Fee Related
-
1993
- 1993-04-01 IL IL10525593A patent/IL105255A/xx not_active IP Right Cessation
- 1993-04-06 MX MX9301986A patent/MX9301986A/es not_active Application Discontinuation
- 1993-04-08 HU HU9402911A patent/HUT71354A/hu unknown
- 1993-04-08 WO PCT/FR1993/000352 patent/WO1993021155A1/fr active IP Right Grant
- 1993-04-08 DE DE69319235T patent/DE69319235T2/de not_active Expired - Lifetime
- 1993-04-08 CA CA002133840A patent/CA2133840A1/fr not_active Abandoned
- 1993-04-08 AT AT93909005T patent/ATE167472T1/de active
- 1993-04-08 PL PL93305360A patent/PL172754B1/pl unknown
- 1993-04-08 US US08/313,121 patent/US5484804A/en not_active Expired - Lifetime
- 1993-04-08 RU RU94045855A patent/RU2127260C1/ru active
- 1993-04-08 AU AU39565/93A patent/AU667214B2/en not_active Ceased
- 1993-04-08 NZ NZ251730A patent/NZ251730A/en unknown
- 1993-04-08 EP EP93909005A patent/EP0635003B1/fr not_active Expired - Lifetime
- 1993-04-08 JP JP51804193A patent/JP3205557B2/ja not_active Expired - Lifetime
- 1993-04-08 SK SK1220-94A patent/SK279032B6/sk unknown
- 1993-04-08 ZA ZA932527A patent/ZA932527B/xx unknown
- 1993-04-08 ES ES93909005T patent/ES2118232T3/es not_active Expired - Lifetime
- 1993-04-08 CZ CZ942482A patent/CZ284213B6/cs unknown
- 1993-04-08 DK DK93909005T patent/DK0635003T3/da active
- 1993-04-09 TW TW082102664A patent/TW234119B/zh active
-
1994
- 1994-10-03 NO NO943692A patent/NO300417B1/no not_active IP Right Cessation
- 1994-10-06 KR KR1019940703538A patent/KR950700880A/ko not_active Application Discontinuation
- 1994-10-07 FI FI944729A patent/FI105023B/sv active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI105023B (sv) | Förfarande för framställning av terapeutiskt användbara difenyl-4-perhydroisoindolderivat | |
EP0711280B1 (fr) | Derives de perhydroisoindole comme antagonistes de la substance p | |
US5102667A (en) | Isoindolone derivatives, their preparation and the pharmaceutical compositions containing them | |
EP0586490B1 (fr) | Derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent | |
HUT70490A (en) | Novel thiopyranopyrrole derivatives, pharmaceutical compositions containing them and process for preparing them | |
US5739351A (en) | Perhydroisoindole derivatives as substance P antagonists | |
HUT65590A (en) | Novel derivatives of thiopyranopyrrole and preparation thereof | |
HU214574B (hu) | Eljárás izoindolonszármazékok előállítására | |
FI105022B (sv) | Nya difenyl-4-perhydroisoindolderivat, deras framställning och användning | |
CZ258495A3 (en) | Novel derivatives of perhydroisoindole, process of their preparation and pharmaceutical compositions containing thereof |