FI102833B1 - Menetelmä peptidin tai proteiinin syntetisoimiseksi ja menetelmässä käyttökelpoinen polystyreeniketjuilla oksastettu polymeerisubstraatti - Google Patents

Menetelmä peptidin tai proteiinin syntetisoimiseksi ja menetelmässä käyttökelpoinen polystyreeniketjuilla oksastettu polymeerisubstraatti

Info

Publication number
FI102833B1
FI102833B1 FI911029A FI911029A FI102833B1 FI 102833 B1 FI102833 B1 FI 102833B1 FI 911029 A FI911029 A FI 911029A FI 911029 A FI911029 A FI 911029A FI 102833 B1 FI102833 B1 FI 102833B1
Authority
FI
Finland
Prior art keywords
synthesizing
peptide
protein
polymeric substrate
polystyrene chains
Prior art date
Application number
FI911029A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI911029A0 (fi
FI102833B (fi
Inventor
Rolf H Berg
Kristoffer Almdal
Walther Batsberg Pedersen
Arne Holm
James P Tam
Robert Bruce Merrifield
Original Assignee
Risoe Forskningscenter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Risoe Forskningscenter filed Critical Risoe Forskningscenter
Publication of FI911029A0 publication Critical patent/FI911029A0/fi
Application granted granted Critical
Publication of FI102833B1 publication Critical patent/FI102833B1/fi
Publication of FI102833B publication Critical patent/FI102833B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
FI911029A 1988-09-01 1991-02-28 Menetelmä peptidin tai proteiinin syntetisoimiseksi ja menetelmässä kä yttökelpoinen polystyreeniketjuilla oksastettu polymeerisubstraatti FI102833B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23952588A 1988-09-01 1988-09-01
US23952588 1988-09-01
DK8900201 1989-08-31
PCT/DK1989/000201 WO1990002749A1 (en) 1988-09-01 1989-08-31 Peptide synthesis method and solid support for use in the method

Publications (3)

Publication Number Publication Date
FI911029A0 FI911029A0 (fi) 1991-02-28
FI102833B1 true FI102833B1 (fi) 1999-02-26
FI102833B FI102833B (fi) 1999-02-26

Family

ID=22902538

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911029A FI102833B (fi) 1988-09-01 1991-02-28 Menetelmä peptidin tai proteiinin syntetisoimiseksi ja menetelmässä kä yttökelpoinen polystyreeniketjuilla oksastettu polymeerisubstraatti

Country Status (8)

Country Link
EP (1) EP0433345B1 (no)
JP (1) JP2807522B2 (no)
AU (1) AU4225889A (no)
CA (1) CA1339987C (no)
DE (1) DE68914843T2 (no)
FI (1) FI102833B (no)
NO (1) NO180198C (no)
WO (1) WO1990002749A1 (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55990D0 (da) * 1990-03-02 1990-03-02 Risoe Forskningscenter Faste baerematerialer til anvendelse i biosystemer
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US6414112B1 (en) 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
US6713602B1 (en) 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5766855A (en) * 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
DK72493D0 (da) * 1993-06-18 1993-06-18 Risoe Forskningscenter Solid supports for use in peptide synthesis and assays
US6710164B1 (en) 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
US5629152A (en) * 1994-08-01 1997-05-13 Isis Pharmaceuticals, Inc. Trisubstituted β-lactams and oligo β-lactamamides
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド Ｐｎａ−ｄｎａキメラと、このキメラ合成用のｐｎａシントン
GB9727126D0 (en) * 1997-12-22 1998-02-25 Zeneca Ltd Process
JP2004503673A (ja) * 2000-07-14 2004-02-05 ミモトープス・プロプライエタリー・リミテッド 活性化モジュラーグラフト重合表面
AUPR224600A0 (en) 2000-12-21 2001-01-25 Polymerat Pty Ltd Novel polymers
EP1572896A4 (en) * 2001-07-30 2006-06-07 Angiotech Biocoatings Corp PFROPFPOLYMERMATRIZES
US7169916B2 (en) 2002-04-01 2007-01-30 Isis Pharmaceuticals, Inc. Chloral-free DCA in oligonucleotide synthesis
ATE528320T1 (de) 2002-05-10 2011-10-15 Bio Layer Pty Ltd Erzeugung von oberflächenbeschichtungsdivergenz
EP2708541B1 (en) 2003-11-13 2015-01-28 Isis Pharmaceuticals, Inc. 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis
AU2004296412B2 (en) 2003-12-12 2011-03-10 Anteo Technologies Pty Ltd A method for designing surfaces
AU2005259833B2 (en) 2004-07-02 2011-09-22 Anteo Technologies Pty Ltd Use of metal complexes
WO2010005693A1 (en) 2008-06-23 2010-01-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cyclized ngr peptide compounds, compositions, and methods of their use
KR102237882B1 (ko) 2012-08-15 2021-04-07 아이오니스 파마수티컬즈, 인코포레이티드 변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
BR122022014984B1 (pt) 2016-05-24 2024-03-05 Sarepta Therapeutics, Inc Compostos oligômeros morfolino fosforodiamidato
EP3463363A4 (en) 2016-05-24 2020-02-19 Sarepta Therapeutics, Inc. METHOD FOR PRODUCING PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS
MA45362A (fr) 2016-05-24 2019-04-10 Sarepta Therapeutics Inc Procédés de préparation d'oligomères morpholino de phosphorodiamidate
CN109562123A (zh) 2016-05-24 2019-04-02 萨勒普塔医疗公司 磷酸二酰胺吗啉代寡聚物药物组合物
SG11201809502YA (en) 2016-05-24 2018-12-28 Sarepta Therapeutics Inc Processes for preparing phosphorodiamidate morpholino oligomers
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
LT3464306T (lt) 2016-05-24 2024-05-10 Sarepta Therapeutics, Inc. Fosforodiamidato morfolino oligomerų gamybos būdas
WO2021025899A1 (en) 2019-08-02 2021-02-11 Sarepta Therapeutics, Inc. Phosphorodiamidate morpholino oligomer pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593880A1 (de) * 1967-06-16 1970-10-29 Farbwerk Hoechst Ag Vorm Meist Verfahren zur Herstellung von Peptiden
AU426743B2 (en) * 1967-09-21 1972-07-21 MONASH UNIVERSITY, and ICI AUSTRALIA LIMITED Processes forthe production of peptides and proteins
FR2078974A5 (no) * 1970-02-25 1971-11-05 Hoffmann La Roche

Also Published As

Publication number Publication date
WO1990002749A1 (en) 1990-03-22
FI911029A0 (fi) 1991-02-28
JP2807522B2 (ja) 1998-10-08
EP0433345B1 (en) 1994-04-20
NO180198B (no) 1996-11-25
NO910812D0 (no) 1991-02-28
DE68914843T2 (de) 1994-11-10
DE68914843D1 (de) 1994-05-26
FI102833B (fi) 1999-02-26
AU4225889A (en) 1990-04-02
JPH04501709A (ja) 1992-03-26
EP0433345A1 (en) 1991-06-26
CA1339987C (en) 1998-08-04
NO910812L (no) 1991-04-26
NO180198C (no) 1997-03-05

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