ES8802512A1 - Proceso para producir derivados de 1,4-dihidro-piridina-3,5-dicarboxilato - Google Patents

Proceso para producir derivados de 1,4-dihidro-piridina-3,5-dicarboxilato

Info

Publication number
ES8802512A1
ES8802512A1 ES557371A ES557371A ES8802512A1 ES 8802512 A1 ES8802512 A1 ES 8802512A1 ES 557371 A ES557371 A ES 557371A ES 557371 A ES557371 A ES 557371A ES 8802512 A1 ES8802512 A1 ES 8802512A1
Authority
ES
Spain
Prior art keywords
pct
image
group
effects
lower alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557371A
Other languages
English (en)
Other versions
ES557371A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Publication of ES8802512A1 publication Critical patent/ES8802512A1/es
Publication of ES557371A0 publication Critical patent/ES557371A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS DERIVADOS DE LA 1,4-DIHIDRO-PIRIDINA-3,5-DICARBOXILATO (I), DONDE NO EXCLUSIVAMENTE, R ES IMIDAZOLILO, AR1 HALOGENO, NITRO O TRIFLUOROMETILO, R2 ALQUILO INFERIOR, X CH O N, A ALQUILENO INFERIOR, M VA DE 1 A 3 Y N DE 1 A 2; SE OBTIENEN POR REACCION DE UN COMPUESTO (II) CON UN ENAMINESTER (III), ENTRE 30 Y 180GC Y DE 2 A 24 HORAS, EN PRESENCIA O NO DE DISOLVENTE COM ETANOL O CLOROFORMO, EN UNA VARIACION DEL PROCESO DE SINTESIS DE PIRIDINA DE HANTZSCH. LOS COMPUESTOS (I) SON VASODILATADORES Y EXHIBEN ACTIVIDAD HIPERCINEMICA, INHIBIDORA DE AGREGACION DE TROMBOCITOS, INHIBIDORA DE LA FORMACION DE TROMBOXANO A2, POR LO QUE SON APLICABLES EN FORMACION POR TODAS ESTAS ACTIVIDADES Y PARTICULARMENTE PARA LA TERAPIA DE LA ARTERIOSCLEROSIS. *FORMULA*
ES557371A 1984-08-14 1987-02-09 Proceso para producir derivados de 1,4-dihidro-piridina-3,5-dicarboxilato Expired ES8802512A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59169588A JPS6147477A (ja) 1984-08-14 1984-08-14 新規１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体

Publications (2)

Publication Number Publication Date
ES8802512A1 true ES8802512A1 (es) 1988-06-16
ES557371A0 ES557371A0 (es) 1988-06-16

Family

ID=15889265

Family Applications (3)

Application Number Title Priority Date Filing Date
ES546136A Expired ES8707185A1 (es) 1984-08-14 1985-08-14 Proceso para producir derivados de 1,4-dihidro-piridina-3,5,dicarboxilato.
ES557371A Expired ES8802512A1 (es) 1984-08-14 1987-02-09 Proceso para producir derivados de 1,4-dihidro-piridina-3,5-dicarboxilato
ES557372A Expired ES8801206A1 (es) 1984-08-14 1987-02-09 Proceso para producir derivados de 1,4-dihidro-piridina-3,5-dicarboxilato

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES546136A Expired ES8707185A1 (es) 1984-08-14 1985-08-14 Proceso para producir derivados de 1,4-dihidro-piridina-3,5,dicarboxilato.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557372A Expired ES8801206A1 (es) 1984-08-14 1987-02-09 Proceso para producir derivados de 1,4-dihidro-piridina-3,5-dicarboxilato

Country Status (10)

Country Link
US (1) US4737506A (es)
EP (1) EP0190364A4 (es)
JP (1) JPS6147477A (es)
KR (1) KR860700252A (es)
AU (1) AU577152B2 (es)
DK (1) DK165686D0 (es)
ES (3) ES8707185A1 (es)
HU (1) HU195500B (es)
NO (1) NO861422L (es)
WO (1) WO1986001206A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0379579A4 (en) * 1988-02-03 1991-01-02 Yoshitomi Pharmaceutical Industries, Ltd. Pharmaceutical composition having improved releasability
WO1990009377A1 (en) * 1989-02-17 1990-08-23 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr Alcaline salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido) ethane sulphonic acid and method of obtaining them
EP0448091B1 (en) * 1990-03-23 1998-08-05 The Green Cross Corporation Pharmaceutical composition containing slightly water-soluble drug
DE4233347A1 (de) * 1992-10-05 1994-04-07 Bayer Ag Dihydropyridin-alkoxy- und -alkylamino-aroylester
ATE252563T1 (de) * 1995-12-27 2003-11-15 Mitsubishi Pharma Corp Vorsorge-/heilmittel fur die komplikationen von diabetes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
JPS5720953B2 (es) * 1974-04-18 1982-05-04
JPS575790B2 (es) * 1974-04-25 1982-02-01
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS56140989A (en) * 1980-04-03 1981-11-04 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydrophyridine-3,5-dicarboxylic ester derivative or its salt
JPS57200386A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts
JPS58131982A (ja) * 1982-02-01 1983-08-06 Tokyo Tanabe Co Ltd 新規なる１．４−ジヒドロピリジン誘導体
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
JPS60215684A (ja) * 1984-04-11 1985-10-29 Toyama Chem Co Ltd 新規な１，４−ジヒドロピリジン誘導体およびその塩類

Also Published As

Publication number Publication date
EP0190364A4 (en) 1987-02-12
NO861422L (no) 1986-04-11
JPS6147477A (ja) 1986-03-07
US4737506A (en) 1988-04-12
ES546136A0 (es) 1987-07-16
KR860700252A (ko) 1986-08-01
AU577152B2 (en) 1988-09-15
EP0190364A1 (en) 1986-08-13
HU195500B (en) 1988-05-30
DK165686A (da) 1986-04-11
DK165686D0 (da) 1986-04-11
ES8801206A1 (es) 1988-01-01
ES557372A0 (es) 1988-01-01
HUT40644A (en) 1987-01-28
JPH0374666B2 (es) 1991-11-27
ES8707185A1 (es) 1987-07-16
WO1986001206A1 (en) 1986-02-27
AU4721785A (en) 1986-03-07
ES557371A0 (es) 1988-06-16

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