ES8802234A1 - Un metodo para preparar un peptido o una sal no toxica del mismo - Google Patents

Un metodo para preparar un peptido o una sal no toxica del mismo

Info

Publication number
ES8802234A1
ES8802234A1 ES543284A ES543284A ES8802234A1 ES 8802234 A1 ES8802234 A1 ES 8802234A1 ES 543284 A ES543284 A ES 543284A ES 543284 A ES543284 A ES 543284A ES 8802234 A1 ES8802234 A1 ES 8802234A1
Authority
ES
Spain
Prior art keywords
phe
pal
tyr
trp
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543284A
Other languages
English (en)
Other versions
ES543284A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/612,072 external-priority patent/US4569927A/en
Priority claimed from US06/653,867 external-priority patent/US4652550A/en
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of ES543284A0 publication Critical patent/ES543284A0/es
Publication of ES8802234A1 publication Critical patent/ES8802234A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LOS PEPTIDOS DE FORMULA X-R1-(W) D-PHE-R3-R4-R5-R6-R7-ARG-PRO-R10, DONDE NO EXCLUSIVAMENTE X ES HIDROGENO, R1 3,4-DESHIDROPROLINA, R3 D-ALANINA, R4 SER, R5 TYR, R6 D-LYS, R7 NORLEUCINA, R10 GLY-NH2 Y W ES CL, F O NO2; SE OBTIENEN POR COPULACION DE AMINOACIDOS O PEPTIDOS CORTOS PARA OBTENER UN INTERMEDIO DEL QUE SE SCINDEN LOS GRUPOS PROTECTORES, TRAS LO CUAL SE OBTIENE UNA DE SUS SALES NO TOXICAS. ESTOS PEPTIDOS INHIBEN EN LOS MAMIFEROS LA LIBERACION DE GONADOTROPINAS POR LA GLANDULA PITUITARIA, LOS CUALES REGULAN LA OVULACION.
ES543284A 1984-05-21 1985-05-20 Un metodo para preparar un peptido o una sal no toxica del mismo Expired ES8802234A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/612,072 US4569927A (en) 1984-02-23 1984-05-21 GnRH Antagonists IV
US06/653,867 US4652550A (en) 1984-05-21 1984-09-21 GnRH antagonists VII
US69669985A 1985-01-31 1985-01-31

Publications (2)

Publication Number Publication Date
ES543284A0 ES543284A0 (es) 1988-04-16
ES8802234A1 true ES8802234A1 (es) 1988-04-16

Family

ID=27417072

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543284A Expired ES8802234A1 (es) 1984-05-21 1985-05-20 Un metodo para preparar un peptido o una sal no toxica del mismo

Country Status (14)

Country Link
EP (1) EP0162575B1 (es)
JP (1) JPH0725795B2 (es)
AU (1) AU580598B2 (es)
CA (1) CA1302650C (es)
DE (1) DE3583964D1 (es)
DK (1) DK166214C (es)
ES (1) ES8802234A1 (es)
GR (1) GR851205B (es)
HU (1) HU198089B (es)
IL (1) IL74827A (es)
MX (1) MX160995A (es)
NZ (1) NZ212124A (es)
PH (1) PH22655A (es)
PT (1) PT80443B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
EP0328089A3 (en) * 1988-02-10 1990-11-28 Abbott Laboratories Reduced size lhrh analogs
JP2672677B2 (ja) * 1989-02-09 1997-11-05 タツプ・フアーマシユーテイカルズ・インコーポレイテツド Ｌｈｒｈ同族体
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5656727A (en) * 1992-09-15 1997-08-12 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US6602856B1 (en) * 1995-01-17 2003-08-05 J. Mark Quillan Antagonists of alpha-melanocyte stimulating hormone and methods based thereon
CA2432708C (en) 2000-12-22 2011-07-12 Kinerton Limited Process for the synthesis of a peptide having a trp residue
WO2004063221A1 (ja) 2002-12-26 2004-07-29 Takeda Pharmaceutical Company Limited メタスチン誘導体およびその用途
WO2004080479A1 (ja) 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited 性腺機能改善剤
NZ552029A (en) 2004-06-25 2009-01-31 Takeda Pharmaceutical Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933782A (en) * 1974-11-14 1976-01-20 American Home Products Corporation (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates
NZ188987A (en) * 1977-11-30 1982-02-23 Salk Inst For Biological Studi Peptide analogues of luteinizing hormone releasing factor
US4215038A (en) 1978-10-16 1980-07-29 The Salk Institute For Biological Studies Peptides which inhibit gonadal function
US4292313A (en) * 1980-04-15 1981-09-29 The Salk Institute For Biological Studies LRF Antagonists
NZ196558A (en) * 1980-04-15 1984-10-19 Salk Inst For Biological Studi Lrf antagonists and pharmaceutical compositions
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
DE3165535D1 (en) * 1980-06-02 1984-09-20 Andrew Victor Schally Lh-rh antagonists
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
JPS57162562A (en) * 1981-03-30 1982-10-06 Nec Corp Delay wave detecting circuit
ZA829041B (en) * 1981-12-10 1983-09-28 David Howard Coy Lh-rh antagonists
AU9102582A (en) * 1981-12-10 1983-06-16 David Howard Coy Lh-rh antagonists
US4444759A (en) * 1982-07-26 1984-04-24 The Salk Institute For Biological Studies GnRH Antagonists II
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
ZA84912B (en) * 1983-03-10 1984-09-26 Salk Inst For Biological Studi Gnrh antagonists
US4504414A (en) * 1983-03-28 1985-03-12 Board Of Regents, The University Of Texas System Synthetic pyridyl-alanyl decapeptides having antiovulatory activity

Also Published As

Publication number Publication date
EP0162575A2 (en) 1985-11-27
PH22655A (en) 1988-10-28
ES543284A0 (es) 1988-04-16
EP0162575B1 (en) 1991-09-04
HU198089B (en) 1989-07-28
DK224985A (da) 1985-11-22
DK224985D0 (da) 1985-05-21
IL74827A0 (en) 1985-07-31
AU580598B2 (en) 1989-01-19
AU4244785A (en) 1985-11-28
GR851205B (es) 1985-11-25
DK166214B (da) 1993-03-22
HUT37634A (en) 1986-01-23
MX160995A (es) 1990-06-29
JPS60260594A (ja) 1985-12-23
PT80443A (en) 1985-06-01
IL74827A (en) 1989-06-30
NZ212124A (en) 1989-04-26
DE3583964D1 (de) 1991-10-10
EP0162575A3 (en) 1987-10-07
PT80443B (en) 1986-12-15
CA1302650C (en) 1992-06-02
DK166214C (da) 1993-08-16
JPH0725795B2 (ja) 1995-03-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971103