ES8802037A1 - Un procedimiento para la preparacion de nuevos derivados delaminometil-oxooxazolidinil-benceno - Google Patents
Un procedimiento para la preparacion de nuevos derivados delaminometil-oxooxazolidinil-bencenoInfo
- Publication number
- ES8802037A1 ES8802037A1 ES540812A ES540812A ES8802037A1 ES 8802037 A1 ES8802037 A1 ES 8802037A1 ES 540812 A ES540812 A ES 540812A ES 540812 A ES540812 A ES 540812A ES 8802037 A1 ES8802037 A1 ES 8802037A1
- Authority
- ES
- Spain
- Prior art keywords
- benzene derivatives
- antibacterial agents
- derivatives useful
- aminomethyl oxooxazolidinyl
- aminomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LOS DERIVADOS DEL AMINOMETIL-OXOOXAZOLIDINIL-BENCENO (I) DONDE NO EXCLUSIVAMENTE, PARA EL ESTEREOISOMERO 1 Y PARA EL CAEMICO DE D Y 1, A ES -NO2, -CN, Y ES HIDROGENO, FLUOR O -NO2, B ES -NH2, -NH3; SE OBTIENEN, POR LAS ETAPAS: A) PONER UN RACEMICO O UN ISOMERO 1 DE UN COMPUESTO (II) CON L CUALQUIER GRUPO SALIENTE, CON AMONIACO O AMINA PRIMARIA EN ETANOL, ENTRE 50 Y 150JC, DURANTE 1 A 24 HORAS, B) OPCIONALMENTE RESOLVER EL PRODUCTO RACEMATO MEDIANTE CRISTALIZACION DE LA SAL CON UN ACIDO OPTICAMENTE ACTIVO, C) HACER REACCIONAR LA AMINA OBTENIDA EN A) O B) CON UN AGENTE ACILANTE COMO UN CLORURO DE ACIDO O ANHIDRIDO, EN UN DISOLVENTE BASICO COMO PIRIDINA, ENTRE C60 Y 50JC, EN PRESENCIA DE UN REACTIVO COPULANTE COMO EL CLORURO DE METANOLSULFONILO, D) OXIDAR EL PRODUCTO DE C) MEDIANTE UNA SOLUCION ACUOSA DE DIOXIDO DE SELENIO CONTENIENDO PEROXIDO DE HIDROGENO; LA MEZCLA CONTIENE CANTIDADES VARIABLES DE SULFURO, SULFOXIDO Y SULFANO QUE PUEDEN SEPARARSE POR CROMATOGRAFIA. SON AGENTES ANTIBACTERIANOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50189783A | 1983-06-07 | 1983-06-07 | |
US57833284A | 1984-02-14 | 1984-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8802037A1 true ES8802037A1 (es) | 1988-03-16 |
ES540812A0 ES540812A0 (es) | 1988-03-16 |
Family
ID=27053956
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533097A Granted ES533097A0 (es) | 1983-06-07 | 1984-06-04 | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
ES540812A Expired ES8802037A1 (es) | 1983-06-07 | 1985-02-28 | Un procedimiento para la preparacion de nuevos derivados delaminometil-oxooxazolidinil-benceno |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533097A Granted ES533097A0 (es) | 1983-06-07 | 1984-06-04 | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0127902B1 (es) |
AU (1) | AU583250B2 (es) |
CA (2) | CA1254213A (es) |
DE (1) | DE3485162D1 (es) |
DK (1) | DK279584A (es) |
ES (2) | ES533097A0 (es) |
FI (1) | FI83216C (es) |
GR (1) | GR82361B (es) |
HU (1) | HU194194B (es) |
IE (1) | IE57619B1 (es) |
IL (1) | IL72028A (es) |
MX (1) | MX169619B (es) |
NO (1) | NO163451C (es) |
NZ (1) | NZ208395A (es) |
PT (1) | PT78703A (es) |
SU (2) | SU1505442A3 (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
US5099026A (en) * | 1986-09-12 | 1992-03-24 | Crater Davis H | Fluorochemical oxazolidinones |
CA1323370C (en) * | 1986-09-12 | 1993-10-19 | Davis H. Crater | Fluorochemical oxazolidinones |
US5039690A (en) * | 1987-10-09 | 1991-08-13 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
US5032605A (en) * | 1987-10-09 | 1991-07-16 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US5036093A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4985429A (en) * | 1987-10-09 | 1991-01-15 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US5036092A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
US4942183A (en) * | 1987-10-16 | 1990-07-17 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
CA1320730C (en) * | 1987-10-16 | 1993-07-27 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
ATE95176T1 (de) * | 1987-10-21 | 1993-10-15 | Du Pont Merck Pharma | Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel. |
US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
WO1990002744A1 (en) * | 1988-09-15 | 1990-03-22 | The Upjohn Company | In position 3 substituted-5-beta-amidomethyl-oxazolidin-2-ones |
US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
JP3176626B2 (ja) * | 1991-11-01 | 2001-06-18 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌剤として有用な置換アリール−およびヘテロアリールフェニルオキサゾリジノン類 |
RU2119484C1 (ru) * | 1992-12-08 | 1998-09-27 | Дзе Апджон Компани | Тропонзамещенный фенилоксазолидинон или его фармацевтически приемлемые соли или гидраты |
TW299332B (es) * | 1992-12-08 | 1997-03-01 | Upjohn Co | |
MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
SK282869B6 (sk) * | 1994-10-26 | 2003-01-09 | Pharmacia + Upjohn Company | Antimikrobiálne fenyloxazolidinóny |
MX9703040A (es) * | 1995-09-12 | 1997-07-31 | Upjohn Co | Antimicrobianos de feniloxazolidinona. |
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
US6218413B1 (en) | 1997-05-30 | 2001-04-17 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
US6255304B1 (en) | 1997-05-30 | 2001-07-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
AU9001598A (en) * | 1997-09-11 | 1999-03-29 | Hokuriku Seiyaku Co. Ltd | Thiourea derivatives |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
KR20010015910A (ko) * | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
NZ515754A (en) | 1999-05-27 | 2003-10-31 | Upjohn Co | Bicyclic oxazolidinone compounds, pharmaceuticals thereof and their use as antibacterial agents |
US6297242B1 (en) * | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
US6518285B2 (en) * | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
ATE321024T1 (de) | 2000-10-17 | 2006-04-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonverbindungen |
DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
CA2624310C (en) | 2005-10-04 | 2014-01-07 | Bayer Healthcare Ag | Polymorphic form of 5-chloro-n-({5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide |
DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
KR101653570B1 (ko) | 2011-03-30 | 2016-09-02 | 주식회사 레고켐 바이오사이언스 | 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1222708A (en) * | 1968-10-22 | 1971-02-17 | Delalande Sa | Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation |
US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
AU560666B2 (en) * | 1981-12-04 | 1987-04-16 | E.I. Du Pont De Nemours And Company | P(2-oxo oxazolidinyl)benzene sulphonamides |
CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
-
1984
- 1984-06-04 ES ES533097A patent/ES533097A0/es active Granted
- 1984-06-05 AU AU29099/84A patent/AU583250B2/en not_active Expired
- 1984-06-05 CA CA000455844A patent/CA1254213A/en not_active Expired
- 1984-06-05 IL IL72028A patent/IL72028A/xx not_active IP Right Cessation
- 1984-06-05 DE DE8484106400T patent/DE3485162D1/de not_active Expired - Lifetime
- 1984-06-05 EP EP84106400A patent/EP0127902B1/en not_active Expired - Lifetime
- 1984-06-06 SU SU843752502A patent/SU1505442A3/ru active
- 1984-06-06 GR GR74940A patent/GR82361B/el unknown
- 1984-06-06 DK DK279584A patent/DK279584A/da unknown
- 1984-06-06 NO NO842273A patent/NO163451C/no unknown
- 1984-06-06 IE IE1407/84A patent/IE57619B1/en not_active IP Right Cessation
- 1984-06-06 HU HU842192A patent/HU194194B/hu not_active IP Right Cessation
- 1984-06-06 PT PT78703A patent/PT78703A/pt not_active IP Right Cessation
- 1984-06-06 NZ NZ208395A patent/NZ208395A/en unknown
- 1984-06-06 FI FI842273A patent/FI83216C/fi not_active IP Right Cessation
- 1984-06-06 MX MX006049A patent/MX169619B/es unknown
-
1985
- 1985-02-28 ES ES540812A patent/ES8802037A1/es not_active Expired
-
1986
- 1986-02-07 SU SU864024095A patent/SU1426451A3/ru active
-
1988
- 1988-10-20 CA CA000580778A patent/CA1275652C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0127902A2 (en) | 1984-12-12 |
AU583250B2 (en) | 1989-04-27 |
IE841407L (en) | 1984-12-07 |
FI83216C (fi) | 1991-06-10 |
AU2909984A (en) | 1984-12-13 |
MX169619B (es) | 1993-07-15 |
HUT34462A (en) | 1985-03-28 |
FI842273A0 (fi) | 1984-06-06 |
IL72028A (en) | 1988-05-31 |
NZ208395A (en) | 1987-07-31 |
HU194194B (en) | 1988-01-28 |
IE57619B1 (en) | 1993-02-10 |
EP0127902B1 (en) | 1991-10-16 |
DK279584A (da) | 1984-12-08 |
ES8506659A1 (es) | 1985-08-01 |
GR82361B (es) | 1984-12-13 |
EP0127902A3 (en) | 1987-09-02 |
DE3485162D1 (de) | 1991-11-21 |
NO163451B (no) | 1990-02-19 |
PT78703A (en) | 1984-07-01 |
IL72028A0 (en) | 1984-10-31 |
ES533097A0 (es) | 1985-08-01 |
ES540812A0 (es) | 1988-03-16 |
NO163451C (no) | 1990-05-30 |
NO842273L (no) | 1984-12-10 |
DK279584D0 (da) | 1984-06-06 |
CA1254213A (en) | 1989-05-16 |
FI842273A (fi) | 1984-12-08 |
SU1426451A3 (ru) | 1988-09-23 |
FI83216B (fi) | 1991-02-28 |
SU1505442A3 (ru) | 1989-08-30 |
CA1275652C (en) | 1990-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970612 |