ES8801910A1 - Un procedimiento para la preparacion de fenilalquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos - Google Patents

Un procedimiento para la preparacion de fenilalquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos

Info

Publication number
ES8801910A1
ES8801910A1 ES557784A ES557784A ES8801910A1 ES 8801910 A1 ES8801910 A1 ES 8801910A1 ES 557784 A ES557784 A ES 557784A ES 557784 A ES557784 A ES 557784A ES 8801910 A1 ES8801910 A1 ES 8801910A1
Authority
ES
Spain
Prior art keywords
compounds
reduction
dihydrobenzofurans
phenylalkyl
inflammatory agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557784A
Other languages
English (en)
Other versions
ES557784A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8801910A1 publication Critical patent/ES8801910A1/es
Publication of ES557784A0 publication Critical patent/ES557784A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

LOS FENILALQUIL-2,3-DIHIDROBENZOFURANOS Y LOS CORRESPONDIENTES HIDROBENZOPIRANOS (I) DONDE M ES 1 A 4, N ES 2 O 3, R ES 1 A 3, A FENILO SUSTITUIDO CON (R1)Q, CON Q ENTRE 1 Y 5 Y R HIDROGENO, HALOGENO Y OTROS; SE PREPARAN POR REACCION DE WITTIG ENTRE (II) Y (III), DONDE (M-1) I 1 Y O/ ES FENILO SEGUIDO DE REDUCCION, POR EJEMPLO MEDIANTE HIDROGENO A 40 PSI, A TEMPERATURA AMBIENTE, CON CATALIZADOR DE OXIDO DE PLATINO Y EN UNA DISOLUCION DE ACIDO ACETICO Y ALCOHOL ETILICO. FARMACEUTICAMENTE UTIL EN EL TRATAMIENTO DE DIVERSAS ENFERMEDADES INFLAMATORIAS, ESPECIALMENTE LAS DERMATOLOGICAS.
ES557784A 1985-04-25 1987-12-15 Un procedimiento para la preparacion de fenilalquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos Expired ES8801910A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/727,317 US4713393A (en) 1985-04-25 1985-04-25 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
ES8801910A1 true ES8801910A1 (es) 1988-03-01
ES557784A0 ES557784A0 (es) 1988-03-01

Family

ID=24922190

Family Applications (2)

Application Number Title Priority Date Filing Date
ES554335A Expired ES8802040A1 (es) 1985-04-25 1986-04-24 Un procedimiento para la preparacion de fenialquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos
ES557784A Expired ES8801910A1 (es) 1985-04-25 1987-12-15 Un procedimiento para la preparacion de fenilalquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES554335A Expired ES8802040A1 (es) 1985-04-25 1986-04-24 Un procedimiento para la preparacion de fenialquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos

Country Status (7)

Country Link
US (1) US4713393A (es)
EP (1) EP0199235B1 (es)
JP (1) JPS61251679A (es)
CA (1) CA1308416C (es)
DE (1) DE3673217D1 (es)
DK (1) DK188286A (es)
ES (2) ES8802040A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753725B2 (ja) * 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
EP0640609A1 (en) * 1993-08-24 1995-03-01 Ono Pharmaceutical Co., Ltd. Fused phenol derivatives having inhibitory activity on TXA2 synthetase, and 5-lipoxygenase and scavenging activity on oxygen species
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
EP1830186A1 (en) * 2006-03-01 2007-09-05 ETH Zürich High-throughput cell-based screening system
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US7632119B1 (en) * 2008-08-11 2009-12-15 Cheng Uei Precision Industry Co., Ltd. Power adapter
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE650987A (es) * 1963-07-25 1965-01-25
DE2315349A1 (de) * 1973-03-28 1974-10-03 Bayer Ag Nicht verfaerbende alterungsschutzmittel
US4100294A (en) * 1976-12-06 1978-07-11 Merck & Co., Inc. 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives
DE2803544A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue benzofuran- und benzoxepinderivate
US4189496A (en) * 1978-02-16 1980-02-19 Merck & Co., Inc. 2,3-Dihydro-5-thienylmethyl and furylmethyl-6-substituted and 6,7-disubstituted-benzofuran-2-carboxylic acid
GR75101B (es) * 1980-10-23 1984-07-13 Pfizer
US4490531A (en) * 1981-07-01 1984-12-25 The Upjohn Company Pyridyl-substituted-benzofurans
US4495357A (en) * 1981-07-01 1985-01-22 The Upjohn Company Pyridyl-substituted-benzofurans
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
US4537903A (en) * 1983-10-12 1985-08-27 Merck & Co., Inc. Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents

Also Published As

Publication number Publication date
DK188286A (da) 1986-10-26
EP0199235A3 (en) 1987-08-05
EP0199235B1 (en) 1990-08-08
CA1308416C (en) 1992-10-06
JPH0415230B2 (es) 1992-03-17
DK188286D0 (da) 1986-04-24
DE3673217D1 (de) 1990-09-13
EP0199235A2 (en) 1986-10-29
ES557784A0 (es) 1988-03-01
ES554335A0 (es) 1988-03-16
JPS61251679A (ja) 1986-11-08
US4713393A (en) 1987-12-15
ES8802040A1 (es) 1988-03-16

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